In this study, we aimed to investigate the safety of levofloxacin, which provides many advantages in older patients.
📌 3 Key Takeaways
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Objective & Hypothesis:Aim: Levofloxacin is one of the most prescribed antibacterial agents.
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Key Findings & Data:They are used for the treatment of many infections, which are of paramount importance for geriatric practice.
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Conclusion & Impact:In this study, we aimed to investigate the safety of levofloxacin, which provides many advantages in older patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Apati · Deliryum · Levofloksasin
Abstract
Aim: Levofloxacin is one of the most prescribed antibacterial agents. They are used for the treatment of many infections, which are of paramount importance for geriatric practice. In this study, we aimed to investigate the safety of levofloxacin, which provides many advantages in older patients.
Özet
Amaç: Levofloksasin en sık reçete edilen antibakteriyel ajanlardan biridir. Geriatri pratiğinde önemli olan birçok enfeksiyonun tedavisinde kullanılmaktadır. Bu çalışmada yaşlı hastalarda birçok avantaj sağlayan levofloksasinin güvenilirliğini araştırmayı amaçladık.
SAKAR, K., AYDIN, A. E., DOKUZLAR, Ö., KOCYIGIT, S. E. (2021). Safety of Levofloxacin in Older Adults. Geriatrik Bilimler Dergisi, Cilt: 4 - Sayı: 2, 45–51. https://ajindex.com/articles/761387
Liu X, Ma J, Huang L, et al. Fluoroquinolones increase the risk of serious arrhythmias: A systematic review and meta-analysis. Medicine (Baltimore). 2017; 96(44):e8273
Bidell MR, Lodise TP. Fluoroquinolone-Associated Tendinopathy: Does Levofloxacin Pose the Greatest Risk? Pharmacotherapy. 2016; 36(6):679–93
Ates Bulut E, Soysal P, Isik AT. Frequency and coincidence of geriatric syndromes according to age groups: Single-center experience in Turkey between 2013 and 2017. Clin Interv Aging. 2018;13:1899–905
Gao CH, Yu LS, Zeng S, et al. Personalized therapeutics for levofloxacin: A focus on pharmacokinetic concerns. Ther Clin Risk Manag. 2014; 10:217–27
Noreddin AM, Elkhatib WF. Levofloxacin in the treatment of community-acquired pneumonia. Expert Rev Anti Infect Ther. 2010; 8(5):505–14
Kuula LSM, Viljemaa KM, Backman JT, et al. Fluoroquinolone-related adverse events resulting in health service use and costs: A systematic review. PLoS One. 2019; 14(4):e0216029
Liu HH. Safety profile of the fluoroquinolones: Focus on levofloxacin. Drug Saf. 2010; 33(5):353–69
Shi S, Klotz U. Age-related changes in pharmacokinetics. Curr Drug Metab. 2011; 12(7):601–10
Bazett HC. An analysis of the time-relations of electrocardiograms. Heart. 1920; 7:353–70
Straus SMJM, Kors JA, De Bruin ML, et al. Prolonged QTc interval and risk of sudden cardiac death in a population of older adults. J Am Coll Cardiol. 2006; 47(2):362–7
Vandael E, Vandenberk B, Vandenberghe J, et al. Risk factors for QTc-prolongation: systematic review of the evidence. Int J Clin Pharm. 2017; 39(1):16–25
Marin RS, Biedrzycki RC, Firinciogullari S. Reliability and validity of the apathy evaluation scale. Psychiatry Res. 1991; 38(2):143–62
Gulseren S, Atun C, Erol A, et al. Apati değerlendirme ölçeği Türkçe formunun geçerlilik ve güvenilirlik çalışması. Nöropsikiatri Arşivi. 2001; 38(3):142–50
Inouye SK, Van Dyck CH, Alessi CA, et al. Clarifying confusion: The confusion assessment method: A new method for detection of delirium. Ann Intern Med. 1990; 113(12):941–8