CYTOTOXIC ACTIVITY OF PLATINUM(II) AND PLATINUM(IV) COMPLEXES BEARING 5(6)-NON/CHLOROSUBSTITUTED-2- HYDROXYMETHYL BENZIMIDAZOLE LIGANDS AGAINST HEp-2 CELL LINE :
In general the complexes, which were found to be more active than carboplatin exhibited moderate cyctotoxicity comparable to cisplatin on the human HEp-2 cell line
📌 3 Key Takeaways
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Objective & Hypothesis:In vitro cytotoxic activities of four platinum(II) and four platinum(IV) complexes with the structures [PtL2Cl2], [PtL2I2] and [PtL2Cl4], [PtL2Cl2(OH)2] (L= 5(6)-non/chloro-substituted-2hydroxymethyl benzimidazole ligands as “non-leaving groups”) respectively were tested on the human HEp-2 (larynx carcinoma) cell line using Cell Culture Method.
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Key Findings & Data:In vitro cytotoxic activities of four platinum(II) and four platinum(IV) complexes with the structures [PtL2Cl2], [PtL2I2] and [PtL2Cl4], [PtL2Cl2(OH)2] (L= 5(6)-non/chloro-substituted-2hydroxymethyl benzimidazole ligands as “non-leaving groups”) respectively were tested on the human HEp-2 (larynx carcinoma) cell line using Cell Culture Method.
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Conclusion & Impact:In general the complexes, which were found to be more active than carboplatin exhibited moderate cyctotoxicity comparable to cisplatin on the human HEp-2 cell line
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Benzimidazol · Sitotoksik aktivite · HEp-2 hücre hattı
Abstract
In vitro cytotoxic activities of four platinum(II) and four platinum(IV) complexes with the structures [PtL2Cl2], [PtL2I2] and [PtL2Cl4], [PtL2Cl2(OH)2] (L= 5(6)-non/chloro-substituted-2hydroxymethyl benzimidazole ligands as “non-leaving groups”) respectively were tested on the human HEp-2 (larynx carcinoma) cell line using Cell Culture Method. In general the complexes, which were found to be more active than carboplatin exhibited moderate cyctotoxicity comparable to cisplatin on the human HEp-2 cell line
Özet
Yapıları sırasıyla [PtL2Cl2], [PtL2I2] ve [PtL2Cl4], [PtL2Cl2(OH)2] (L= 5(6)-non/kloro-substitüe-2hidroksimetilbenzimidazol “taşıyıcı ligand”) olan dört platin(II) ve dört platin(IV) kompleksi in vitro sitotoksik aktivitleri Hücre Kültür Metodu kullanılarak insan HEp-2 (larinks kanseri) hücre hattında test edildi. Genel olarak insan HEp-2 hücre hattına karşı, karboplatinden daha aktif bulunan kompleksler sisplatin ile karşılaştırılabilir sitotoksik etki gösterdi
Utku, S. (2007). CYTOTOXIC ACTIVITY OF PLATINUM(II) AND PLATINUM(IV) COMPLEXES BEARING 5(6)-NON/CHLOROSUBSTITUTED-2- HYDROXYMETHYL BENZIMIDAZOLE LIGANDS AGAINST HEp-2 CELL LINE :. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 36 Sayı: 1, 21–30. https://doi.org/10.1501/Eczfak_0000000074