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Journals / Ankara Üniversitesi Eczacılık Fakültesi Dergisi / 2026 / Cilt: 50 Sayı: 3

AN OVERVIEW OF CURRENT RESEARCH ON THE DEVELOPMENT OF ANTHRAQUINONES AS ANTICANCER AGENTS

ANTRAKİNONLARIN ANTİKANSER AJANLARI OLARAK GELİŞTİRİLMESİNE YÖNELİK GÜNCEL ARAŞTIRMALARA GENEL BİR BAKIŞ

Burcu Karayavuz(Sağlık Bilimleri Üniversitesi Eczacılık Fakültesi Farmasötik Kimya Anabilim Dalı)0000-0001-9631-2575
Cigdem Karaaslan Kirmizioglu(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, GÜLHANE ECZACILIK FAKÜLTESİ, ECZACILIK MESLEK BİLİMLERİ BÖLÜMÜ, FARMASÖTİK KİMYA ANABİLİM DALI)0000-0003-1918-1377
Pages
879–893
Publication Date
2026-09-19
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Literature data suggest that new anthraquinone derivatives developed through structural modifications can exhibit better antiproliferative activity against resistant cancer cells than currently existing anthracyclines and may be more effective antitumor drug candidates.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: In this study, some scientific studies on anthraquinone compounds that have been synthesized in recent years and have been found to have high in vitro and in vivo anticancer activity are summarized.
📊
Key Findings & Data:It is aimed to contribute to the design and development of new anthraquinone derivative drugs that are more effective in cancer treatment and can overcome drug resistance.
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Conclusion & Impact:Literature data suggest that new anthraquinone derivatives developed through structural modifications can exhibit better antiproliferative activity against resistant cancer cells than currently existing anthracyclines and may be more effective antitumor drug candidates.
🔬Design:Derleme
📍Scope:Comprehensive Sample
⚙️Variables:Antrasiklin · antrakinon · antikanser aktivite

Abstract

Objective: In this study, some scientific studies on anthraquinone compounds that have been synthesized in recent years and have been found to have high in vitro and in vivo anticancer activity are summarized. It is aimed to contribute to the design and development of new anthraquinone derivative drugs that are more effective in cancer treatment and can overcome drug resistance. Result and Discussion: Anthraquinones are a privileged class of compounds that can be obtained from natural and synthetic sources and have anticancer properties with versatile mechanisms. Anthracyclines, which are potent topoisomerase inhibitors, are members of this class that are frequently used in cancer chemotherapy. Literature data suggest that new anthraquinone derivatives developed through structural modifications can exhibit better antiproliferative activity against resistant cancer cells than currently existing anthracyclines and may be more effective antitumor drug candidates.

Özet

Amaç: Bu çalışmada son yıllarda sentezlenmiş ve yüksek in vitro ve in vivo antikanser aktivite gösterdiği bulunmuş antrakinon bileşiklerine dair bazı bilimsel çalışmalar özetlenmiştir. K anser tedavisinde daha etkili ve ilaç direncini aşabilecek yeni antrakinon türevi ilaçların tasarlanması ve geliştirilmesine katkı sunması amaçlanmıştır. Sonuç ve Tartışma: Antrakinonlar, doğal ve sentetik kaynaklardan elde edilebilen ve çok yönlü mekanizmalarla antikanser özelliklere sahip ayrıcalıklı bir bileşik sınıfıdır. Güçlü topoizomeraz inhibitörleri olan antrasiklinler, bu sınıfın kanser kemoterapisinde sıklıkla kullanılan üyelerini oluşturur. Literatür verileri, yapısal modifikasyonlar ile dirençli kanser hücrelerine karşı mevcut antrasiklinlerden daha iyi antiproliferatif aktivite gösteren ve antitümör ilaç adayı olabilecek yeni antrakinon bileşiklerinin geliştirilebileceğini göstermektedir.

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Cite This Article

Karayavuz, B., Kirmizioglu, C. K. (2026). AN OVERVIEW OF CURRENT RESEARCH ON THE DEVELOPMENT OF ANTHRAQUINONES AS ANTICANCER AGENTS. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 50 Sayı: 3, 879–893. https://doi.org/10.33483/jfpau.1714226

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