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Journals / Ankara Üniversitesi Eczacılık Fakültesi Dergisi / 2026 / Cilt: 45 Sayı: 2

STUDY ON SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF SOME MICHAEL-TYPE ADDITION COMPOUNDS

BAZI MICHAEL TİPİ KATIM ÜRÜNLERİNİN SENTEZ ÇALIŞMASI VE ANTİMİKROBİYAL AKTİVİTELERİ

Gül Bayram(Mersin University, Department of Medical Services and Techniques, Vocational School of Health Services, Mersin, Turkey)0000-0002-4154-8596
Abdoul Nzeyımana(Mersin University, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mersin, Turkey Ege University, Department of Biochemistry, Faculty of Sciences, Izmir, Turkey)0000-0002-1887-510X
Semra Utku(Mersin University, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mersin, Turkey)0000-0003-3181-9134
Mahmut Ülger(Mersin University, Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Turkey)0000-0001-6649-4195
Gönül Aslan(Mersin University, Department of Medical Microbiology, Faculty of Medicine, Mersin, Turkey)0000-0002-1221-7907
Erdoğan Berçın(Berçin Pharmacy, Side, Antalya)0000-0002-7318-8361
Pages
182–193
Publication Date
2021-05-31
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this study, the aim is to synthesize the series of new Michael type addition products 2-amino-3-[(2-nitro-1-phenylpropyl)thio]propanoic acid (IIa-IIg) and to investigate their in vitro, antibacterial, antifungal and antitubercular activity.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Multidrug-resistant pathogenic bacteria, fungi, and Mycobacterium tuberculosis infections continue to be increasingly widespread worldwide.
📊
Key Findings & Data:In organic chemistry, the tiya-Michael type addition is also significant reaction in the synthesis of bioactive compounds.
💡
Conclusion & Impact:In this study, the aim is to synthesize the series of new Michael type addition products 2-amino-3-[(2-nitro-1-phenylpropyl)thio]propanoic acid (IIa-IIg) and to investigate their in vitro, antibacterial, antifungal and antitubercular activity.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Antibakteriyel aktivite · antifungal aktivite · antimikobakteriyel etki

Abstract

Objective: Multidrug-resistant pathogenic bacteria, fungi, and Mycobacterium tuberculosis infections continue to be increasingly widespread worldwide. In organic chemistry, the tiya-Michael type addition is also significant reaction in the synthesis of bioactive compounds. In this study, the aim is to synthesize the series of new Michael type addition products 2-amino-3-[(2-nitro-1-phenylpropyl)thio]propanoic acid (IIa-IIg) and to investigate their in vitro, antibacterial, antifungal and antitubercular activity.

Özet

Amaç: Çoklu ilaca dirençli patojenik bakteri, mantar ve Mycobacterium tuberculosis enfeksiyonları dünya çapında giderek yaygınlaşmaya devam etmektedir. Organik kimyada, tiya-Michael tipi katım ayrıca biyoaktif bileşiklerin sentezinde önemli bir reaksiyondur. Bu çalışmada, 2-amino-3-[(2-nitro-1-fenilpropil)tiyo]propanoik asit Michael tip yeni katım ürünlerinin (IIa-IIg) sentezi ve antibakteriyel, antifungal ve antitüberküler aktivitelerinin araştırılması amaçlanmıştır.

🔖

Cite This Article

Bayram, G., Nzeyımana, A., Utku, S., Ülger, M., Aslan, G., Berçın, E. (2021). STUDY ON SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF SOME MICHAEL-TYPE ADDITION COMPOUNDS. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 45 Sayı: 2, 182–193. https://doi.org/10.33483/jfpau.867768

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