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Journals / Turkish Journal of Chemistry / 2007 / Cilt: 31 - Sayı: 4

Synthesis and Cytotoxic Activity of Platinum(II) and Platinum(IV) Complexes with 2-Hydroxymethylbenzimidazole or 5(6)-Chloro-2-hydroxymethylbenzimidazole Ligands against MCF-7 and HeLa Cell Lines

Semra UTKU
Fatma GÜMÜŞ
Sibel GÜR
Aykut ÖZKUL
Pages
503–514
Publication Date
2007-04-01
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The complexes, which were found to be less active than cisplatin, exhibited cyctotoxicity comparable to carboplatin on the human MCF-7 and HeLa cell lines.

📌 3 Key Takeaways

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Objective & Hypothesis:Four platinum(II) and 4 platinum(IV) complexes with the structures [PtL2Cl2], [PtL2I2], [PtL2Cl4], and [PtL2Cl2(OH)2] (L = 5(6)-non/orchloro-substituted-2-hydroxymethylbenzimidazole ligands as ``non-leaving groups''), respectively, were synthesized and characterized by their elemental analyses, and IR and 1H-NMR spectra.
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Key Findings & Data:In vitro cytotoxic activities of the platinum(II) and platinum(IV) complexes were tested against the human MCF-7 (breast cancer) and HeLa (cervix cancer) cell lines using the cell culture method.
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Conclusion & Impact:The complexes, which were found to be less active than cisplatin, exhibited cyctotoxicity comparable to carboplatin on the human MCF-7 and HeLa cell lines.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Benzimidazole · cytotoxic activity · HeLa cell line

Abstract

Four platinum(II) and 4 platinum(IV) complexes with the structures [PtL2Cl2], [PtL2I2], [PtL2Cl4], and [PtL2Cl2(OH)2] (L = 5(6)-non/orchloro-substituted-2-hydroxymethylbenzimidazole ligands as ``non-leaving groups''), respectively, were synthesized and characterized by their elemental analyses, and IR and 1H-NMR spectra. In vitro cytotoxic activities of the platinum(II) and platinum(IV) complexes were tested against the human MCF-7 (breast cancer) and HeLa (cervix cancer) cell lines using the cell culture method. In general, the platinum(II) complexes were more active than the corresponding platinum(IV) complexes. The complexes, which were found to be less active than cisplatin, exhibited cyctotoxicity comparable to carboplatin on the human MCF-7 and HeLa cell lines.

Özet

Four platinum(II) and 4 platinum(IV) complexes with the structures [PtL2Cl2], [PtL2I2], [PtL2Cl4], and [PtL2Cl2(OH)2] (L = 5(6)-non/orchloro-substituted-2-hydroxymethylbenzimidazole ligands as ``non-leaving groups''), respectively, were synthesized and characterized by their elemental analyses, and IR and 1H-NMR spectra. In vitro cytotoxic activities of the platinum(II) and platinum(IV) complexes were tested against the human MCF-7 (breast cancer) and HeLa (cervix cancer) cell lines using the cell culture method. In general, the platinum(II) complexes were more active than the corresponding platinum(IV) complexes. The complexes, which were found to be less active than cisplatin, exhibited cyctotoxicity comparable to carboplatin on the human MCF-7 and HeLa cell lines.

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Cite This Article

UTKU, S., GÜMÜŞ, F., GÜR, S., ÖZKUL, A. (2007). Synthesis and Cytotoxic Activity of Platinum(II) and Platinum(IV) Complexes with 2-Hydroxymethylbenzimidazole or 5(6)-Chloro-2-hydroxymethylbenzimidazole Ligands against MCF-7 and HeLa Cell Lines. Turkish Journal of Chemistry, Cilt: 31 - Sayı: 4, 503–514. https://ajindex.com/articles/185488

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