SavedAdd your journal

Journals / Türk Psikiyatri Dergisi / 2019 / Cilt: 30 - Sayı: 2

Effects of Nitric Oxide Synthase-1 Exon 1f-VNTR Gene Polymorphism on the Clinical Symptoms of Alcohol Dependence, Impulsivity and Comorbid Attention Deficit Hyperactivity Disorder

Alkol Bağımlılarında Nitrik Oksit Sentaz-1 Ekzon 1f-VNTR Gen Polimorfizmi’nin Bağımlılık ile İlişkili Klinik Özellikler, Dürtüsellik ve Eşlik Eden Dikkat Eksikliği Hiperaktivite Belirtileri Üzerine Etkisi

İbrahim KARAKAYA
Şeref Can GÜREL
Yavuz AYHAN
Mehmet Ali KAŞİFOĞLU
Sevilay KARAHAN
Melih Önder BABAOĞLU
Erol GÖKA
Hilmiye Nesrin DİLBAZ
Berna Diclenur ULUĞ
Başaran DEMİR
Pages
82–89
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Results of our study do not indicatea significant association between the NOS1 exon 1f-VNTR genotypes and AD, subgroups of AD, impulsiveness or comorbid ADHD semptoms.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: We planned to compare individuals with alcohol dependence (AD) and healthy controls on the frequency of NOS1 exon 1f-VNTR gene polymorphism and to investigate the effects of this polymorphism on the clinical symptoms of alcohol dependence, impulsiveness and comorbid attention deficit hyperactivity disorder (ADHD) symptoms.
📊
Key Findings & Data:Method: A total of 282 participants consisting of 153 patients and 129 age and gender matched healthy individuals were inluded in the study.
💡
Conclusion & Impact:Conclusion: Results of our study do not indicatea significant association between the NOS1 exon 1f-VNTR genotypes and AD, subgroups of AD, impulsiveness or comorbid ADHD semptoms.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: We planned to compare individuals with alcohol dependence (AD) and healthy controls on the frequency of NOS1 exon 1f-VNTR gene polymorphism and to investigate the effects of this polymorphism on the clinical symptoms of alcohol dependence, impulsiveness and comorbid attention deficit hyperactivity disorder (ADHD) symptoms. Method: A total of 282 participants consisting of 153 patients and 129 age and gender matched healthy individuals were inluded in the study. All participants were evaluated with Structured Clinical Interview for DSM-IV Axis 1 disorders (SCID-I) and Michigan Alcohol Screening Test (MAST), Barratt Impulsiveness Scale (BIS-11), UPPS Impulsive Behavior Scale, Adult Attention Deficit and Hyperactivity Diagnosis Scale (ADHDS), Family History Research Diagnostic Criteria (FHDRC). The QF-PCR fragment protocols were used for genetic analyses. Allele fragments of ≤176 bp and >176 bp sizes were separated and 3 different genotypes were determined as the SS, SL and LL. Associations of these genotypes with symptoms of AD severity, impulsiveness and comorbid ADHD were investigated. Results: The AD and control groups did not differ significantly on the basis of NOS1 exon 1f-VNTR gene polymorphism. Also, significant correlations between this polymorphism and symptoms of AD severity, impulsiveness and ADHD were not determined. Conclusion: Results of our study do not indicatea significant association between the NOS1 exon 1f-VNTR genotypes and AD, subgroups of AD, impulsiveness or comorbid ADHD semptoms.

Özet

Amaç: Alkol bağımlılığı (AB) tanısı konan bireyler ile sağlıklı kontrollerin NOS1 ekzon 1f-VNTR polimorfizmi açısından karşılaştırılması ve bu polimorfizmin bağımlılık ile ilişkili özellikler, dürtüsellik ve eşlik eden dikkat eksikliği hiperaktivite bozukluğu (DEHB) belirtileri ile ilişkisinin araştırılması planlanmıştır. Yöntem: AB tanısı olan 153 hasta ve yaş ve cinsiyet açısından eşleştirilmiş 129 kontrol olmak üzere toplam 282 katılımcı değerlendirilmiştir. Tüm katılımcılara DSM-IV I. Eksen Bozuklukları için Yapılandırılmış Klinik Görüşme Çizelgesi (SCID-I) uygulanmıştır. Ayrıca Michigan Alkolizm Tarama Testi, Barratt Dürtüsellik Ölçeği-11, UPPS Dürtüsel Davranış Ölçeği, Erişkin DEHB Ölçeği ve Aile Öyküsü - Araştırma Tanı Ölçütleri uygulanmıştır. Genetik analiz, QF-PCR fragman analizi protokolleri kullanılarak yapılmıştır. Alel büyüklükleri kısa (≤176 bp) ve uzun (>176 bp) olmak üzere ayrılarak, örneklerde 3 farklı genotip (SS, SL, LL) tayin edilmiştir. Bu polimorfizm ile AB tanısı, AB alt tipleri, AB şiddeti, dürtüsellik ve DEHB belirtileri arasındaki ilişki incelenmiştir. Bulgular: AB ve kontrol grubu karşılaştırıldığında NOS1 ekzon 1f-VNTR gen polimorfizmi açısından istatistiksel olarak fark saptanmamıştır. Bu polimorfizm ile AB şiddeti, AB alt tipleri, dürtüsellik ve DEHB belirtileri arasında da anlamlı ilişki tespit edilmemiştir. Sonuç: Çalışma sonunda NOS1 ekzon 1f-VNTR genotip dağılımı ile alkol bağımlığı ve bağımlılık alt gurupları, dürtüsellik ve eşlik eden DEHB belirtileri arasında herhangi bir ilişki saptanmamıştır.

🔖

Cite This Article

KARAKAYA, İ., GÜREL, Ş. C., AYHAN, Y., KAŞİFOĞLU, M. A., KARAHAN, S., BABAOĞLU, M. Ö., GÖKA, E., DİLBAZ, H. N., ULUĞ, B. D., DEMİR, B. (2019). Effects of Nitric Oxide Synthase-1 Exon 1f-VNTR Gene Polymorphism on the Clinical Symptoms of Alcohol Dependence, Impulsivity and Comorbid Attention Deficit Hyperactivity Disorder. Türk Psikiyatri Dergisi, Cilt: 30 - Sayı: 2, 82–89. https://ajindex.com/articles/87842

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Adams ML, Meyer ER, Sewing BN ve ark. (1994) Effects of nitric oxide-related agents on alcohol narcosis. Alcohol Clin Exp Res 18:969-75.
  2. Adams ML, Sewing BN, Chen J ve ark. (1995) Nitric oxide-related agents alter alcohol withdrawal in male rats. Alcohol Clin Exp Res19: 195-9.
  3. Andreasen NC, Endicott J, Spitzer RL (1977) The family history method using diagnostic criteria. Reliability and validity. Arch Gen Psychiatry 34: 1229- 35. Aspide R, Gironi Carnevale UA, Sergeant JA ve ark. (1998) Non-selective attention and nitric oxide in putative animal models of Attention-Deficit Hyperactivity Disorder. Behav Brain Res 95: 123-33.
  4. Aspide R, Fresiello A, De Filippis G ve ark. (2000) Non-selective attention in a rat model of hyperactivity and attention deficit: subchronic methylphenydate and nitric oxide synthesis inhibitor treatment. Neurosci Biobehav Rev 24: 59-71.
  5. Ayhan Y, Gürel SC, Karaca Ö ve ark. (2014) Association between ADH1Cand ALDH2 polymorphisms and alcoholism in a Turkish sample. Nord J Psychiatry 64:1-7.
  6. Babor TF, Hofmann MI, DelBoca FK ve ark. (1992)
  7. Types of alcoholics, I. Evidence for an empirically derived typology based on indicator of vulnerability and severity. Arch Gen Psychiatry 49: 599-608.
  8. Basu D, Ball SA, Feinn R, Gelernter J ve ark. (2004) Typologies of drug dependence: comparative validity of a multivariate and four univariate models. Drug Alcohol Depend 73: 289-300.
  9. Biederman J, Willens T, Mick E ve ark. (1995) Psychoactive substance use disorders in adults with ADHD: effects of ADHD and psychiatric comorbidity. Am J Psychiatry 152:1652-8.
  10. Ceylan M, Sener S, Bayraktar AC ve ark. (2010) Oxidative imbalance in child and adolescent patients with attention - deficit / hyperactivity disorder. Prog Neuropsychopharmacol Biol Psychiatry 34:1491-4.
  11. Chiavegatto S, Nelson RJ (2003) Interaction of nitric oxide and serotonin in aggressive behavior. Horm Behav 44: 233-41.
  12. Coşkunol H, Bağdiken I, SoriasS (1995) Michigan Alkolizm Tarama Testi (MATT) Geçerliliği. Ege Tıp Derg 34: 15-8.
  13. Dawson VL, Dawson TM (1995) Physiological and toxicological actions of nitric oxide in the central nervous system. Adv Pharmacol 34: 323-42.
  14. First MB, Spitzer RL, Gibbon M ve ark. (1996) Structured Clinical Interview for DSM-IV Axis I Disorders, Clinician Version (SCID-CV), Washington DC, American Psychiatric Publishing Inc. Foroud T, Li TK (1999) Genetics of alcoholism: a review of recent studies in human and animal models. Am J Addict. 8: 261-78.
  15. Gao Y, Heldt SA (2015)