Journals / Abant Tıp Dergisi / 2026 / Cilt: 7 Sayı: 1

Evaluation of Colistin Nephrotoxicity in Intensive Care Diseases of Patient

Yoğun Bakım Hastalarında Kolistin Nefrotoksisitesinin Değerlendirilmesi

Fatma Kaplan Efe(Keçiören Eğitim ve Araştırma Hastanesi, İç Hastalıkları, Ankara, Türkiye)
Fatma Ayerden Ebinç(Keçiören Eğitim Ve Araştırma Hastanesi, Nefroloji, Ankara, Türkiye)
Serdar Karakaya(Keçiören Eğitim ve Araştırma Hastanesi, İç Hastalıkları, Ankara, Türkiye)
İbrahim Karadağ(Keçiören Eğitim ve Araştırma Hastanesi, İç Hastalıkları, Ankara, Türkiye)
Murat Eser(Keçiören Eğitim ve Araştırma Hastanesi, İç Hastalıkları, Ankara, Türkiye)
Oktay Ünsal(Keçiören Eğitim ve Araştırma Hastanesi, İç Hastalıkları, Ankara, Türkiye)
Aysun Aybal Kutlugün(Keçiören Eğitim Ve Araştırma Hastanesi, Nefroloji, Ankara, Türkiye)
Esin Beyan(Keçiören Eğitim ve Araştırma Hastanesi, İç Hastalıkları, Ankara, Türkiye)
Pages
10–14
Publication Date
2018-01-01
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Patients who developed nephrotoxicity had a higher mortality rate p: 0.01 .DISCUSSION AND CONCLUSION: Nephrotoxicity of colistin should be noted in ICU patients.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:INTRODUCTION: Evaluation of the development of nephrotoxicity and the factors affecting it in patients treated with colistin theraphMETHODS: 51 patients who received colistin treatment were divided into two groups as nephrotoxicity developing and nondeveloping.
📊
Key Findings & Data:Demographic and laboratory data between the groups were comparedRESULTS: Colistin induced nephrotoxicity was detected in 64.7% of the patients.
💡
Conclusion & Impact:Patients who developed nephrotoxicity had a higher mortality rate p: 0.01 .DISCUSSION AND CONCLUSION: Nephrotoxicity of colistin should be noted in ICU patients.
🔬Design:Makale
📍Scope:Comprehensive Sample
⚙️Variables:Kolistin · nefrotoksisite · yoğun bakım

Abstract

INTRODUCTION: Evaluation of the development of nephrotoxicity and the factors affecting it in patients treated with colistin theraphMETHODS: 51 patients who received colistin treatment were divided into two groups as nephrotoxicity developing and nondeveloping. Demographic and laboratory data between the groups were comparedRESULTS: Colistin induced nephrotoxicity was detected in 64.7% of the patients. Patients who developed nephrotoxicity had a higher mortality rate p: 0.01 .DISCUSSION AND CONCLUSION: Nephrotoxicity of colistin should be noted in ICU patients.

Özet

GİRİŞ ve AMAÇ: Bu çalışmanın amacı, Kolistin verilen hastalarda nefrotoksisite gelişiminin ve bunu etkileyen faktörlerin değerlendirilmesidir. YÖNTEM ve GEREÇLER: Kolistin verilen 51 hasta nefrotoksiste gelişen ve gelişmeyenler olarak iki gruba ayrıldı. Gruplar, demografik özellikler ve laboratuar verileri yönünden karşılaştırıldı.BULGULAR: Hastaların %64,7’sinde kolistine bağlı nefrotoksisite saptandı. Nefrotoksisite gelişen hastaların ölüm oranı daha yüksek bulundu p: 0,01 .TARTIŞMA ve SONUÇ: Yoğun bakım hastalarında kolistin nefrotoksisitesine dikkat edilmelidir.

🔖

Cite This Article

Efe, F. K., Ebinç, F. A., Karakaya, S., Karadağ, İ., Eser, M., Ünsal, O., Kutlugün, A. A., Beyan, E. (2018). Evaluation of Colistin Nephrotoxicity in Intensive Care Diseases of Patient. Abant Tıp Dergisi, Cilt: 7 Sayı: 1, 10–14. https://doi.org/10.5505/abantmedj.2018.39306

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (18)

  1. Falagas ME, Kasiakou SK. Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections. Clin Infect Dis. 2005 May 1;40(9):1333-41.
  2. Biswas S, Brunel JM, Dubus JC, Reynaud-Gaubert M, Rolain JM. Colistin: an update on the antibiotic of the 21st century. Expert Rev Anti Infect Ther.2012 Aug;10(8):917-34.
  3. Pike M, Saltiel E. Colistin and polymyxin-induced nephrotoxicity: focus on literature utilizing the RIFLE classification scheme of acute kidney injury. J Pharm Pract. 2014 Dec;27(6):554-61.
  4. Doshi NM, Mount KL, Murphy CV. Nephrotoxicity associated with intravenous colistin in critically ill patients. Pharmacotherapy. 2011 Dec;31(12):1257-64.
  5. Berg JR, Spilker CM, Lewis SA. Effects of polymyxin B on mammalian urinary bladder. J Membr Biol. 1996 Nov;154(2):119-30.
  6. Hartzell JD, Neff R, Ake J, Howard R, Olson S, Paolino K, Vishnepolsky M, Weintrob A, Wortmann G. Nephrotoxicity associated with intravenous colistin (colistimethate sodium) treatment at a tertiary care medical center. Clin Infect Dis. 2009 Jun 15;48(12):1724-8.
  7. Tuon FF, Rigatto MH, Lopes CK, Kamei LK, Rocha JL, Zavascki AP. Risk factors for acute kidney injury in patients treated with polymyxin B or colistin methanesulfonate sodium. Int J Antimicrob Agents. 2014 Apr;43(4):349-52.
  8. Rocco M, Montini L, Alessandri E, Venditti M, Laderchi A, De Pascale G, RaponiG, Vitale M, Pietropaoli P, Antonelli M. Risk factors for acute kidney injury in critically ill patients receiving high intravenous doses of colistin methanesulfonate and/or other nephrotoxic antibiotics: a retrospective cohort study. Crit Care. 2013 Aug 14;17(4)
  9. Dewan A, Shoukat M. Evaluation of risk of nephrotoxicity with high dose, extended-interval colistin administration. Indian J Crit Care Med. 2014 Jul;18(7):427-30.
  10. Garzotto F, Piccinni P, Cruz D, Gramaticopolo S, Dal Santo M, Aneloni G, Kim JC, Rocco M, Alessandri E, Giunta F, Michetti V, Iannuzzi M, Belluomo Anello C,Brienza N, Carlini M, Pelaia P, Gabbanelli V, Ronco C; NEFROINT investigation group. RIFLE-based data collection/ management system applied to a prospective cohort multicenter Italian study on the epidemiology of acute kidney injury in the intensive care unit. Blood Purif. 2011;31(1-3):159-71.
  11. Cheng CY, Sheng WH, Wang JT, Chen YC, Chang SC. Safety and efficacy of intravenous colistin (colistin methanesulphonate) for severe multidrug-resistant Gram- negative bacterial infections. Int J Antimicrob Agents. 2010 Mar;35(3):297-300.
  12. Hartzell JD, Neff R, Ake J, Howard R, Olson S, Paolino K, Vishnepolsky M,Weintrob A, Wortmann G. Nephrotoxicity associated with intravenous colistin (colistimethate sodium) treatment at a tertiary care medical center. Clin Infect Dis. 2009 Jun 15;48(12):1724-8.
  13. Rattanaumpawan P, Ungprasert P, Thamlikitkul V. Risk factors for colistin-associated nephrotoxicity. J Infect. 2011 Feb;62(2):187-90.
  14. Deryke CA, Crawford AJ, Uddin N, Wallace MR. Colistin dosing and nephrotoxicity in a large community teaching hospital. Oct;54(10):4503-5. Chemother. 2010
  15. Sabuda DM, Laupland K, Pitout J, Dalton B, Rabin H, Louie T, Conly J. Utilization of colistin for treatment of multidrug- resistant Pseudomonas aeruginosa. Can J Infect Dis Med Microbiol. 2008 Nov;19(6):413-8.
  16. Nation RL, Li J. Colistin in the 21st century. Curr Opin Infect Dis. 2009Dec;22(6):535-43.
  17. Pogue JM, Lee J, Marchaim D, Yee V, Zhao JJ, Chopra T, Lephart P, Kaye KS.Incidence of and risk factors for colistin- associated nephrotoxicity in a large academic health system. Clin Infect Dis. 2011 Nov;53(9):879-84.
  18. Ricci Z, Cruz D, Ronco C. The RIFLE criteria and mortality in acute kidney injury: A systematic review. Kidney Int. 2008 Mar;73(5):538-46.