Journals / Ankara Üniversitesi Eczacılık Fakültesi Dergisi / 2020 / Cilt: 44 - Sayı: 3

WOUND HEALING EFFECT OF NARINGIN GEL IN ALLOXAN INDUCED DIABETIC MICE

ALLOKSAN İLE DİYABET OLUŞTURULMUŞ FARELERDE NARİNGİN JELİN YARA İYİLEŞTİRİCİ ETKİLERİ

Pages
397–414
Publication Date
2020-09-30
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Objective: The aim of this study was to investigate the effects of naringin, a known flavonoid, on in vitro cytotoxicity, irritation and in vivo potential efficacy when topically applied to the diabetic wound.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The aim of this study was to investigate the effects of naringin, a known flavonoid, on in vitro cytotoxicity, irritation and in vivo potential efficacy when topically applied to the diabetic wound.
📊
Key Findings & Data:Objective: The aim of this study was to investigate the effects of naringin, a known flavonoid, on in vitro cytotoxicity, irritation and in vivo potential efficacy when topically applied to the diabetic wound.
💡
Conclusion & Impact:Objective: The aim of this study was to investigate the effects of naringin, a known flavonoid, on in vitro cytotoxicity, irritation and in vivo potential efficacy when topically applied to the diabetic wound.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Cell culture · Diabetes mellitus · HET-CAM

Abstract

Objective: The aim of this study was to investigate the effects of naringin, a known flavonoid, on in vitro cytotoxicity, irritation and in vivo potential efficacy when topically applied to the diabetic wound.

Özet

Amaç: Bu çalışmanın amacı, bir flavonoid olan Naringin’in in vitro sitotoksisite, irritasyon ile diyabetik yara üzerindeki in vivo potansiyel etkilerini araştırmaktı.

🔖

Cite This Article

OKUR, M. E., ŞAKUL, A. A., AYLA, Ş., KARADAĞ, A. E., ŞENYÜZ, C. Ş., BATUR, Ş., DAYLAN, B., ÖZDEMİR, E. M., YÜCELİK, Ş. S., SİPAHİ, H., AYDIN, A. (2020). WOUND HEALING EFFECT OF NARINGIN GEL IN ALLOXAN INDUCED DIABETIC MICE. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 44 - Sayı: 3, 397–414. https://ajindex.com/articles/83253

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (10)

  1. Okur, M.E., Karantas, I.D., Siafaka, P.I. (2017). Diabetes Mellitus: A Review on Pathophysiology, Current Status of Oral Pathophysiology, Current Status of Oral Medications and Future Perspectives. Acta Pharmaceutica Sciencia, 55, 61
  2. Shah, S.A., Sohail, M., Khan, S., Minhas, M.U., de Matas, M., Sikstone, V., Hussain Z., Abbasi M., Kousar M.et al. (2019). Biopolymer-based biomaterials for accelerated diabetic wound healing: A critical review. International Journal of Biological Macromolecules, 139, 975–993
  3. Siafaka, P.I., Zisi, A.P., Exindari, M.K., Karantas, I.D., Bikiaris, D.N. (2016). Porous dressings of modified chitosan with poly(2-hydroxyethyl acrylate) for topical wound delivery of levofloxacin. Carbohydrate Polymers, 143, 90–99
  4. Veith, A.P., Henderson, K., Spencer, A., Sligar, A.D., Baker, A.B. (2019). Therapeutic strategies for enhancing angiogenesis in wound healing. Advanced Drug Delivery Reviews, 146, 97–125
  5. Okur, M.E., Karantas, I.D., Şenyiğit, Z., Okur, N.Ü., Siafaka, P.I. (2020). Recent trends on wound management; new therapeutic choices based on polymeric carriers. Asian Journal of Pharmaceutical Sciences, January 23, 2020 6. Rao, S.S., Venkatesan, J., Prabhu, A., Rekha, P.D. (2020). Natural polymeric biomaterials in growth factor delivery for treating diabetic foot ulcers. Journal of Drug Delivery Science and Technology, 55, 101385
  6. Cho, H., Blatchley, M.R., Duh, E.J., Gerecht, S. (2019). Acellular and cellular approaches to improve diabetic wound healing. Advanced Drug Delivery Reviews, 146, 267–288
  7. Kandhare, A.D., Ghosh, P., Bodhankar, S.L. (2014). Naringin, a flavanone glycoside, promotes angiogenesis and inhibits endothelial apoptosis through modulation of inflammatory and growth factor expression in diabetic foot ulcer in rats. Chemico-Biological Interactions, 219, 101–112
  8. Gadelkarim, M., Abushouk, A.I., Ghanem, E., Hamaad, A.M., Saad, A.M. and Abdel-Daim, M.M. (2018). Adipose-derived stem cells: Effectiveness and advances in delivery in diabetic wound healing. Biomedicine and Pharmacotherapy, 107, 625–633
  9. Ahmed, O.M., Mohamed, T., Moustafa, H., Hamdy, H., Ahmed, R.R. and Aboud, E. (2018). Quercetin and low level laser therapy promote wound healing process in diabetic rats via structural reorganization and modulatory effects on inflammation and oxidative stress. Biomedicine and Pharmacotherapy, 101, 58–73
  10. Özay, Y., Güzel, S., Yumrutaş, Ö., Pehlivanoğlu, B., Erdoğdu, İ.H., Yildirim, Z., Türk, B.A.,