Journals / Ankara Üniversitesi Eczacılık Fakültesi Dergisi / 2020 / Cilt: 44 Sayı: 3

WOUND HEALING EFFECT OF NARINGIN GEL IN ALLOXAN INDUCED DIABETIC MICE

ALLOKSAN İLE DİYABET OLUŞTURULMUŞ FARELERDE NARİNGİN JELİN YARA İYİLEŞTİRİCİ ETKİLERİ

Mehmet Evren Okur(UNIVERSITY OF HEALTH SCIENCES)0000-0001-7706-6452
Ayşe Arzu Şakul(İSTANBUL MEDİPOL ÜNİVERSİTESİ)0000-0002-9354-0000
Şule Ayla(ISTANBUL MEDIPOL UNIVERSITY)0000-0003-2143-5268
Ayşe Esra Karadağ(İSTANBUL MEDİPOL ÜNİVERSİTESİ)0000-0002-3412-0807
Şebnem Batur(İSTANBUL ÜNİVERSİTESİ - CERRAHPAŞA)0000-0001-6577-8970
Benay Daylan(İSTANBUL MEDİPOL ÜNİVERSİTESİ)0000-0002-8302-1127
Ekrem Musa Özdemir(İSTANBUL MEDİPOL ÜNİVERSİTESİ)0000-0001-9416-7757
Hande Sipahi(YEDITEPE UNIVERSITY)0000-0001-6482-3143
Ahmet Aydın(YEDITEPE UNIVERSITY)0000-0003-3499-6435
Pages
397–414
Publication Date
2020-09-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Objective: The aim of this study was to investigate the effects of naringin, a known flavonoid, on in vitro cytotoxicity, irritation and in vivo potential efficacy when topically applied to the diabetic wound.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The aim of this study was to investigate the effects of naringin, a known flavonoid, on in vitro cytotoxicity, irritation and in vivo potential efficacy when topically applied to the diabetic wound.
📊
Key Findings & Data:Objective: The aim of this study was to investigate the effects of naringin, a known flavonoid, on in vitro cytotoxicity, irritation and in vivo potential efficacy when topically applied to the diabetic wound.
💡
Conclusion & Impact:Objective: The aim of this study was to investigate the effects of naringin, a known flavonoid, on in vitro cytotoxicity, irritation and in vivo potential efficacy when topically applied to the diabetic wound.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Diabetes mellitus · HET-CAM · Hücre kültürü

Abstract

Objective: The aim of this study was to investigate the effects of naringin, a known flavonoid, on in vitro cytotoxicity, irritation and in vivo potential efficacy when topically applied to the diabetic wound.

Özet

Amaç: Bu çalışmanın amacı, bir flavonoid olan Naringin’in in vitro sitotoksisite, irritasyon ile diyabetik yara üzerindeki in vivo potansiyel etkilerini araştırmaktı.

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Cite This Article

Okur, M. E., Şakul, A. A., Ayla, Ş., Karadağ, A. E., Şenyüz, C. Ş., Batur, Ş., Daylan, B., Özdemir, E. M., Yücelik, Ş. S., Sipahi, H., Aydın, A. (2020). WOUND HEALING EFFECT OF NARINGIN GEL IN ALLOXAN INDUCED DIABETIC MICE. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 44 Sayı: 3, 397–414. https://doi.org/10.33483/jfpau.742224

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References (35)

  1. Okur, M.E., Karantas, I.D., Siafaka, P.I. (2017). Diabetes Mellitus: A Review on Pathophysiology, Current Status of Oral Pathophysiology, Current Status of Oral Medications and Future Perspectives. Acta Pharmaceutica Sciencia, 55, 61.
  2. Shah, S.A., Sohail, M., Khan, S., Minhas, M.U., de Matas, M., Sikstone, V., Hussain Z., Abbasi M., Kousar M.et al. (2019). Biopolymer-based biomaterials for accelerated diabetic wound healing: A critical review. International Journal of Biological Macromolecules, 139, 975–993.
  3. Siafaka, P.I., Zisi, A.P., Exindari, M.K., Karantas, I.D., Bikiaris, D.N. (2016). Porous dressings of modified chitosan with poly(2-hydroxyethyl acrylate) for topical wound delivery of levofloxacin. Carbohydrate Polymers, 143, 90–99.
  4. Veith, A.P., Henderson, K., Spencer, A., Sligar, A.D., Baker, A.B. (2019). Therapeutic strategies for enhancing angiogenesis in wound healing. Advanced Drug Delivery Reviews, 146, 97–125.
  5. Okur, M.E., Karantas, I.D., Şenyiğit, Z., Okur, N.Ü., Siafaka, P.I. (2020). Recent trends on wound management; new therapeutic choices based on polymeric carriers. Asian Journal of Pharmaceutical Sciences, January 23, 2020
  6. Rao, S.S., Venkatesan, J., Prabhu, A., Rekha, P.D. (2020). Natural polymeric biomaterials in growth factor delivery for treating diabetic foot ulcers. Journal of Drug Delivery Science and Technology, 55, 101385.
  7. Cho, H., Blatchley, M.R., Duh, E.J., Gerecht, S. (2019). Acellular and cellular approaches to improve diabetic wound healing. Advanced Drug Delivery Reviews, 146, 267–288.
  8. Kandhare, A.D., Ghosh, P., Bodhankar, S.L. (2014). Naringin, a flavanone glycoside, promotes angiogenesis and inhibits endothelial apoptosis through modulation of inflammatory and growth factor expression in diabetic foot ulcer in rats. Chemico-Biological Interactions, 219, 101–112.
  9. Gadelkarim, M., Abushouk, A.I., Ghanem, E., Hamaad, A.M., Saad, A.M. and Abdel-Daim, M.M. (2018). Adipose-derived stem cells: Effectiveness and advances in delivery in diabetic wound healing. Biomedicine and Pharmacotherapy, 107, 625–633.
  10. Ahmed, O.M., Mohamed, T., Moustafa, H., Hamdy, H., Ahmed, R.R. and Aboud, E. (2018). Quercetin and low level laser therapy promote wound healing process in diabetic rats via structural reorganization and modulatory effects on inflammation and oxidative stress. Biomedicine and Pharmacotherapy, 101, 58–73.
  11. Özay, Y., Güzel, S., Yumrutaş, Ö., Pehlivanoğlu, B., Erdoğdu, İ.H., Yildirim, Z., Türk, B.A., Darcan, S. (2019). Wound healing effect of kaempferol in diabetic and nondiabetic rats. Journal of Surgical Research, 233, 284–296.
  12. Kandhare, A.D., Alam, J., Patil, M.V.K., Sinha, A. and Bodhankar, S.L. (2016). Wound healing potential of naringin ointment formulation via regulating the expression of inflammatory, apoptotic and growth mediators in experimental rats. Pharmaceutical Biology, 54, 419–432.
  13. Karadağ, A.E., Demirci, B., Çaşkurlu, A., Demirci, F., Okur, M.E., Orak, D., Sipahi, H., Başer, K. H. C. (2019). In vitro antibacterial, antioxidant, anti-inflammatory and analgesic evaluation of Rosmarinus officinalis L. flower extract fractions. South African Journal of Botany, 125, 214–220.
  14. Siafaka, P., Okur, M.E., Ayla, Ş., Er, S., Cağlar, E.Ş. (2019). Design and characterization of nanocarriers loaded with Levofloxacin for enhanced antimicrobial activity; physicochemical properties, in vitro release and oral acute toxicity. Brazilian Journal of Pharmaceutical Sciences, 55, 1–13.
  15. Standardization, C.-E.C. for (2009). ISO 10993-5:2009 - Biological evaluation of medical devices- Part 5: Tests for in vitro cytotoxicity. https://www.iso.org/standard/36406.html (21 April 2020).
  16. Üstündağ Okur, N., Filippousi, M., Okur, M.E., Ayla, Ş., Çağlar, E.Ş., Yoltaş, A., Siafaka, P.I. (2018). A novel approach for skin infections: Controlled release topical mats of poly(lactic acid)/poly(ethylene succinate) blends containing Voriconazole. Journal of Drug Delivery Science and Technology, 46, 74–86.
  17. HET-CAM (2010). ICCVAM-Recommended Test Method Protocol: Hen’s Egg Test-Chorioallantoic Membrane (HET-CAM) Test Method.
  18. Okur, M.E., Polat, D.C., Ozbek, H., Yilmaz, S., Yoltas, A., Arslan, R. (2018). Evaluation of the antidiabetic property of capparis ovata desf. Var. Paleastina zoh. Extracts using in vivo and in vitro approaches. Endocrine, Metabolic & Immune Disorders - Drug Targets, 18, 489–501.
  19. Okur, M.E., Ayla, Ş., Çiçek Polat, D., Günal, M.Y., Yoltaş, A. and Biçeroğlu, Ö. (2018). Novel insight into wound healing properties of methanol extract of Capparis ovata Desf. var. palaestina Zohary fruits. Journal of Pharmacy and Pharmacology, 70, 1401–1413.
  20. Galeano, M., Altavilla, D., Bitto, A., Minutoli, L., Calò, M., Cascio, P. Lo, et al. (2006). Recombinant human erythropoietin improves angiogenesis and wound healing in experimental burn wounds*. Critical Care Medicine, 34, 1139–1146.
  21. Özçelik, B., Kartal, M., Orhan, I. (2011). Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids. Pharmaceutical Biology, 49, 396–402.
  22. Budovsky, A., Yarmolinsky, L., Ben-Shabat, S. (2015). Effect of medicinal plants on wound healing. Wound Repair and Regeneration, 23, 171–183.
  23. Gutiérrez-Venegas, G., Gómez-Mora, J.A., Meraz-Rodríguez, M.A., Flores-Sánchez, M.A., Ortiz-Miranda, L.F. (2019). Effect of flavonoids on antimicrobial activity of microorganisms present in dental plaque. Heliyon, 5(12), e03013.
  24. Jang, M.H., Piao, X.L., Kim, J.M., Kwon, S.W., Park, J.H. (2008). Inhibition of cholinesterase and amyloid-&bgr; aggregation by resveratrol oligomers from Vitis amurensis. Phytotherapy Research, 22, 544–549.
  25. Ishaka, A., Ismail, M., Imam, M.U., Mahmud, R., Sani, I.M., Zakaria, Z.A.B. (2017). Toxicity Evaluation, HET-CAM Irritation, and Anti-Irritant Potential of Rice Bran Wax Policosanol Nanoemulsion. Journal of Nano Research, 49, 44–55.
  26. Auner, B.G., Wirth, M., Valenta, C. (2005). Antioxidative activity and cytotoxicity of four different flavonoids for dermal applications. Journal of Drug Delivery Science and Technology, 15, 227–232.
  27. Fan, H., Zhang, P., Zhou, L., Mo, F., Jin, Z., Ma, J., Lin, R., Liu, Y., Zhang J. (2020). Naringin-loaded polymeric micelles as buccal tablets: formulation, characterization, in vitro release, cytotoxicity and histopathology studies. Pharmaceutical Development and Technology, 25(5),547-555.
  28. Sipahi, H., Reis, R., Dinc, O., Kavaz, T., Dimoglo, A., Aydın, A. (2019). In vitro biocompatibility study approaches to evaluate the safety profile of electrolyzed water for skin and eye. Human and Experimental Toxicology, 38, 1314–1326.
  29. Dahl, J.E. (1999). Irritation of dental adhesive agents evaluated by the HET-CAM test. Toxicology in Vitro, 13, 259–264.
  30. Liu, W.Y., Tzeng, T.F., Liu, I.M. (2017). Healing potential of zerumbone ointment on experimental full-thickness excision cutaneous wounds in rat. Journal of Tissue Viability, 26, 202–207.
  31. Suriyamoorthy, S., Subramaniam, K., Jeevan Raj Durai, S., Wahaab, F., Pemila Edith Chitraselvi, R. (2014). Evaluation of wound healing activity of Acacia caesia in rats. Wound Medicine, 7, 1–7.
  32. Abu-Al-Basal, M.A. (2010). Healing potential of Rosmarinus officinalis L. on full-thickness excision cutaneous wounds in alloxan-induced-diabetic BALB/c mice. Journal of Ethnopharmacology, 131, 443–450.
  33. Patel, S., Srivastava, S., Singh, M.R., Singh, D. (2019). Mechanistic insight into diabetic wounds: Pathogenesis, molecular targets and treatment strategies to pace wound healing. Biomedicine and Pharmacotherapy, 112, 108615.
  34. Devalliere, J., Dooley, K., Yu, Y., Kelangi, S.S., Uygun, B.E., Yarmush, M.L. (2017). Co-delivery of a growth factor and a tissue-protective molecule using elastin biopolymers accelerates wound healing in diabetic mice. Biomaterials, 141, 149–160.
  35. Siafaka, P., Okur, M.E., Ayla, Ş., Er, S., Cağlar, E.Ş. (2019). Design and characterization of nanocarriers loaded with Levofloxacin for enhanced antimicrobial activity; physicochemical properties, in vitro release and oral acute toxicity. Brazilian Journal of Pharmaceutical Sciences, 55, 1–13.