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Journals / Medeniyet Medical Journal / 2019 / Cilt: 34 - Sayı: 3

Antioxidant Activity of Blackthorn (Prunus spinosa L.) Fruit Extract and Cytotoxic Effects on Various Cancer Cell Lines

Prunus spinosa L. Ekstresinin Çeşitli Kanser Hücre Soylarındaki Antioksidan ve Sitotoksik Etkileri

Mehmet Evren OKUR
Derya Çiçek POLAT
Nihal KARAKAS
Ayse Esra KARADAG
Sule AYLA
Irem OZTURK
Pages
297–304
Publication Date
2022-10-19
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Differences were considered as statistically significant at p*

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Blackthorn (Prunus spinosa L. (Rosaceae) is a shrup whose fruits are consumed as food in Turkey.
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Key Findings & Data:Method: Methanol extract of P. spinosa fruit was evaluated for its in vitro cytotoxic activity on multiform (GBM) brain cancer (LN229, U87 and T98G) and pancreas cancer (PANC-1 and AsPC-1) cell lines.
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Conclusion & Impact:Differences were considered as statistically significant at p*
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Blackthorn (Prunus spinosa L. (Rosaceae) is a shrup whose fruits are consumed as food in Turkey. This study was aimed to evaluate antioxidant activity of methanol extract of P. spinosa and its cytotoxic effects on cancer cell lines. Method: Methanol extract of P. spinosa fruit was evaluated for its in vitro cytotoxic activity on multiform (GBM) brain cancer (LN229, U87 and T98G) and pancreas cancer (PANC-1 and AsPC-1) cell lines. Cell viability assays were performed by calculating the percentage of viable cells using a luminescence system, and spectrophotometrically. measuring its antioxidant ABTS and DPPH radical scavenging activities. Differences were considered as statistically significant at p*

Özet

Amaç: Çakal eriği (Prunus spinosa L.), Gülgiller (Rosaceae) familyasından bir ağaççık türüdür ve Türkiye’de meyvesi besin olarak tüketilmektedir. Bu çalışma P. spinosa metanol ekstresinin antioksidan aktivitesini ve kanser hücre hatları üzerindeki sitotoksik etkilerini değerlendirmeyi amaçlamıştır. Yöntem: P. spinosa meyvesi metanol ekstresi, glioblastoma multiform (GBM) beyin kanseri (LN229, U-87 ve T98G) ve pankreas kanseri (PANC-1 ve AsPC-1) hücre hatları kullanılarak in vitro sitotoksik aktivitesi araştırılmıştır. Hücre canlılığı deneyleri, biyolüminesans sistemi kullanılarak canlı hücrelerin yüzdesinin ve antioksidan aktivitelerinin, spektrofotometrik olarak ABTS ve DPPH radikalleri ile ölçülmesi yoluyla gerçekleştirilmiştir. İstatiksel anlamlılık eşleştirilmemiş öğrenci t testi ile p*

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Cite This Article

OKUR, M. E., POLAT, D. Ç., KARAKAS, N., KARADAG, A. E., AYLA, S., OZTURK, I. (2022). Antioxidant Activity of Blackthorn (Prunus spinosa L.) Fruit Extract and Cytotoxic Effects on Various Cancer Cell Lines. Medeniyet Medical Journal, Cilt: 34 - Sayı: 3, 297–304. https://ajindex.com/articles/579273

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