AI Summary & Key Takeaways
AI InsightAll of the compounds were inactive against S. aureits, C. krusei and C. parapsilosis Compounds 5b, 9a and 13a (12.5 $mu$g/ml) showed good inhibitors activity against C. albicans.
📌 3 Key Takeaways
Abstract
In this study, thirty nine benzimidazole derivatives namely 1-[(substituted thiocarbamoylhydrazine carbonyl)methylI-2-phenyl- 1H-benzimidazoles la-13a, N-[(2-phenylhenzimidazol-1-yl methyl)-[1,3,4]-thiadiazole-2-yl]-substituted phenyl amines 1b-13b, and 5-(2-phenyl benzimidazol-1-yl-methyl)-4-substituted phenyl-4H-1,2,4-triazole-3-thiones lc-13c were screened for their antimicrobial activities. Minimum Inhibitory Concentration (MlC) values of the compounds were determined by the tube dilution method using Staphylococcus aureus and Bacillus subtilis as Gram positive, Escherichia coli as Gram negative bacteria and Candida albicans, Candida krusei and Candida parapsilosis as yeast-like fungi. All of the compounds were inactive against S. aureits, C. krusei and C. parapsilosis Compounds 5b, 9a and 13a (12.5 $mu$g/ml) showed good inhibitors activity against C. albicans.
Özet
Bu çalışmada,1-[(substitue tiyokarbamoilhidrazinkarbonil)metil]-2-fenil-lH-benzimidazoles, Ia- 13a, N-l(2-fenilbenz.imidazol-I-il metil)-[1,3,4]-tiyadiazol-2-il]-sübstitüe fenil amin, lb-13b, ve 5-(2-fenil benzimidazol-1-il- metil)-4-sübstitüe fenil-4H-l,2,4-triazoI-3-tiyon, lc-13c, türevi 39 adet bileşiğin antimikrobiyal aktiviteleri incelenmiştir. Bileşiklerin Minimum Inhibitor Konsantrasyon (MIK) değerleri Gram pozitif bakteriler olarak Staphylococcus aureus ve Bacillus subtilis, Gram negatif bakteri olarak Escherichia coli ve maya-benzeri funguslar olarak da Candida albicans, Candida krusei ve Candida parapsilosis'e karşı tüp diliisyoıı metodu kullanılarak saptanmıştır. Bileşiklerin hepsi S. aııreus, C. krusei ve C. parapsilosis'e karşı etkisiz bulunmuşlardır. 5b, 9a ve 13a bileşikleri C. albicans'a karşı 12.5 $mu$g/ml MIC değeriyle iyi antifungal aktivite göstermişlerdir.