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Journals / Türk Oftalmoloji Dergisi / 2017 / Cilt: 47 - Sayı: 6

The Protective Effect of Sesamol in the Selenite-induced Experimental Cataract Model

Sodyum Selenitle Oluşturulmuş Deneysel Katarakt Modelinde Sesamolün Koruyucu Etkisi

Burak TURGUT
Nevin İLHAN
İrfan ERGEN
Pages
309–314
Publication Date
2022-11-05
DOI
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⚡ TL;DR(Too Long; Didn't Read)

It was found that the mean cataract grade in the sesamol group was significantly lower than that of the sham group (p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: To investigate the potential protective effects of sesamol in an experimental cataract model.
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Key Findings & Data:All the rats except for those in the control group were injected subcutaneously with a single dose of sodium selenite on postpartum day 9.
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Conclusion & Impact:It was found that the mean cataract grade in the sesamol group was significantly lower than that of the sham group (p
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: To investigate the potential protective effects of sesamol in an experimental cataract model. Materials and Methods: Twenty-one Spraque Dawley rat pups were randomly assigned into three groups, seven rats in each. All the rats except for those in the control group were injected subcutaneously with a single dose of sodium selenite on postpartum day 9. On days 10-14, rats in the sham group were intraperitoneally administered 50 mg/kg/day saline solution, while rats in the sesamol group were given 50 mg/kg/day sesamol by the same route. Following cataract grading, the lenses and capsules were extracted and the mean levels of reduced glutathione (GSH), malondialdehyde (MDA), total antioxidant status (TAS) and total oxidant status (TOS) in lens supernatants were biochemically analyzed. Results: The control group did not show any development of cataract. It was found that the mean cataract grade in the sesamol group was significantly lower than that of the sham group (p

Özet

Amaç: Deneysel katarakt modelinde sesamolün potansiyel koruyucu etkilerini araştırmaktır.Gereç ve Yöntem: Yirmi bir adet Spraque Dawley cinsi sıçan yavrusu rastgele bir şekilde her birinde 7 sıçan bulunan üç gruba ayrıldı.Kontrol grubu dışındaki tüm sıçanlara deneysel katarakt oluşturmak için doğumdan sonraki 9. günde subkutan sodyum selenit enjekteedildi. Onuncu ve 14. günler arasında sham grubundaki sıçanlara intraperitoneal 50 mg/kg/gün salin solüsyonu uygulanırken sesamolgrubunda aynı yolla 50 mg/kg/gün sesamol verildi. Katarakt evrelemeleri yapıldıktan sonra lensler kapsülleriyle birlikte çıkarıldı velens süpernatantlarında ortalama indirgenmiş glutatyon (GSH), malondialdehit (MDA), toplam antioksidan seviyesi (TAS) ve toplamoksidan seviyesi (TOS) biyokimyasal olarak analiz edildi.Bulgular: Kontrol grubu herhangi bir katarakt gelişimi göstermedi. Ortalama GSH ve TAS seviyesi sesamol grubunda shamgrubundakinden anlamlı derecede daha yüksek bulundu (p

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Cite This Article

TURGUT, B., İLHAN, N., ERGEN, İ. (2022). The Protective Effect of Sesamol in the Selenite-induced Experimental Cataract Model. Türk Oftalmoloji Dergisi, Cilt: 47 - Sayı: 6, 309–314. https://ajindex.com/articles/637825

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