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Journals / Türk Oftalmoloji Dergisi / 2020 / Cilt: 50 - Sayı: 5

Optical Coherence Tomography Angiography Findings in Long-Term Follow-up of Leber’s Hereditary Optic Neuropathy: Report of Two Cases

Leber’in Herediter Optik Nöropatisi ile Uzun SüreliTakip Edilen İki Olguda Optik Koherens TomografiAnjiyografi Bulguları

Huban ATİLLA
Pınar Bingöl KIZILTUNÇ
Feyza Tüntaş BİLEN
Pages
313–316
Publication Date
2022-11-06
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Followingup patients with OCTA imaging in the future will provide insight into the pathogenesis and prognosis of LHON.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Leber’s hereditary optic neuropathy (LHON) is thought to be a neurovascular disease due to presence of vascular changes in asymptomaticpatients.
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Key Findings & Data:Here we present 2 patients in whom optical coherence tomography angiography (OCTA) imaging demonstrated capillary drop out areas and decreased radial peripapillary capillary (RPC) density in the quadrants that had thinner retinal nerve fiber layer (RNFL) inOCT images.
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Conclusion & Impact:Followingup patients with OCTA imaging in the future will provide insight into the pathogenesis and prognosis of LHON.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Leber’s hereditary optic neuropathy (LHON) is thought to be a neurovascular disease due to presence of vascular changes in asymptomaticpatients. Here we present 2 patients in whom optical coherence tomography angiography (OCTA) imaging demonstrated capillary drop out areas and decreased radial peripapillary capillary (RPC) density in the quadrants that had thinner retinal nerve fiber layer (RNFL) inOCT images. Progressive decrease in RNFL and RPC density were shown in each patient at month 12 and 30 of follow-up. Followingup patients with OCTA imaging in the future will provide insight into the pathogenesis and prognosis of LHON.

Özet

Leber’in herediter optik nöropatisinin (LHON) asemptomatik hastalarda da izlenen vasküler değişikliklerin görülmesi nedeniyle nörovasküler bir hastalık olduğu düşünülmektedir. Bu olgu raporunda LHON tanısı olan 2 hastada optik koherens tomografi (OKT) görüntülemede retina sinir lifi tabakası (RSLT) kalınlığında azalma izlenen kadranlarda, kapiller drop-out alanları ve azalmış radyal peripapiller kapiller damar dansitesi OKT anjiyografi (OKTA) yöntemi ile tespit edilmiştir. Radyal peripapiller kapiller damar dansitesi ve RSLT kalınlığındaki progresif azalma hastaların 12 ve 30 aylık takiplerinde gösterilmiştir. LHON tanısı olan hastaların OKTA yöntemi ile takibi, gelecekte bu hastalığın patogenezi ve progresyonu hakkında fikir sahibi olunmasını sağlayacaktır

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Cite This Article

ATİLLA, H., KIZILTUNÇ, P. B., BİLEN, F. T. (2022). Optical Coherence Tomography Angiography Findings in Long-Term Follow-up of Leber’s Hereditary Optic Neuropathy: Report of Two Cases. Türk Oftalmoloji Dergisi, Cilt: 50 - Sayı: 5, 313–316. https://ajindex.com/articles/637689

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