The Limonoids and Other Constituents from the Fruits of Melia azedarach and Their Biological Activity

The inhibitory effects of trichilinin G on superoxide anion generation and elastase release by human neutrophils were also assessed in cellular model and did not show significant activity.

📌 3 Key Takeaways

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Objective & Hypothesis:Eleven chemical constituents, including one new limonoid trichilinin G (1), were identified from the fruit extracts of M. azedarach.

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Key Findings & Data:The structure of 1 was established by various spectroscopic and mass spectrometric analyses.

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Conclusion & Impact:The inhibitory effects of trichilinin G on superoxide anion generation and elastase release by human neutrophils were also assessed in cellular model and did not show significant activity.

🔬Design:Modeling & Simulation

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Eleven chemical constituents, including one new limonoid trichilinin G (1), were identified from the fruit extracts of M. azedarach. The structure of 1 was established by various spectroscopic and mass spectrometric analyses. Among the eleven isolated compounds, trichilinin G (1) and meliatoxin B1 (2) were examined for their antifungal activity against Fusarium oxysporum, Magnaporthe grisea, Phytophthora spp. (PS), and P. capsici (PC). Limonoid 2 showed the best antifungal activity against PS (IC50 = 103.8 μg/mL) and PC (IC50 < 62.5 μg/mL) in a dose-dependent manner. While limonoid 1 exhibited a weak to moderate activity against these Phytophthora species, F. oxysporum and M. grisea were less sensitive to the two compounds tested. The inhibitory effects of trichilinin G on superoxide anion generation and elastase release by human neutrophils were also assessed in cellular model and did not show significant activity.

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Cite This Article

THANH, N. T., HOANG, V. D., TUAN, N. N., THANG, T. D., QUANG, L. D., KUO, P., LI, Y., WU, T., HIEN, V. T., HIEU, T. T. (2022). The Limonoids and Other Constituents from the Fruits of Melia azedarach and Their Biological Activity. Records of Natural Products, Cilt: 16 - Sayı: 4, 307–315. https://ajindex.com/articles/588767

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