The Limonoids and Other Constituents from the Fruits of Melia azedarach and Their Biological Activity

The inhibitory effects of trichilinin G on superoxide anion generation and elastase release by human neutrophils were also assessed in cellular model and did not show significant activity.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Eleven chemical constituents, including one new limonoid trichilinin G (1), were identified from the fruit extracts of M. azedarach.

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Temel Bulgular & Veri:The structure of 1 was established by various spectroscopic and mass spectrometric analyses.

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Sonuç & Katkı:The inhibitory effects of trichilinin G on superoxide anion generation and elastase release by human neutrophils were also assessed in cellular model and did not show significant activity.

🔬Tür:Modelleme & Sayısal Simülasyon

📍Kapsam:Genişletilmiş Akademik Örneklem

⚙️Değişkenler:Alan Parametreleri

Abstract

Eleven chemical constituents, including one new limonoid trichilinin G (1), were identified from the fruit extracts of M. azedarach. The structure of 1 was established by various spectroscopic and mass spectrometric analyses. Among the eleven isolated compounds, trichilinin G (1) and meliatoxin B1 (2) were examined for their antifungal activity against Fusarium oxysporum, Magnaporthe grisea, Phytophthora spp. (PS), and P. capsici (PC). Limonoid 2 showed the best antifungal activity against PS (IC50 = 103.8 μg/mL) and PC (IC50 < 62.5 μg/mL) in a dose-dependent manner. While limonoid 1 exhibited a weak to moderate activity against these Phytophthora species, F. oxysporum and M. grisea were less sensitive to the two compounds tested. The inhibitory effects of trichilinin G on superoxide anion generation and elastase release by human neutrophils were also assessed in cellular model and did not show significant activity.

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Bu Makaleye Atıf Yap

THANH, N. T., HOANG, V. D., TUAN, N. N., THANG, T. D., QUANG, L. D., KUO, P., LI, Y., WU, T., HIEN, V. T., HIEU, T. T. (2022). The Limonoids and Other Constituents from the Fruits of Melia azedarach and Their Biological Activity. Records of Natural Products, Cilt: 16 - Sayı: 4, 307–315. https://ajindex.com/articles/588767

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Kaynakça (14)

L. Zhao, C. H. Huo, L. R. Shen, Y. Yang, Q. Zhang and Q. W. Shi (2010). Chemical constituents of plants from the genus Melia, Chem. Biodivers. 7, 839–859
G. Mishra, S. Jawla and V. Srivastava (2013). Melia azedarach: a review, Int. J. Med. Chem. Anal. 3, 53– 56
M. Ervina and Sukardiman (2018). A review: Melia azedarach L. as a potent anticancer drug, Phcog. Rev. 12, 94–102
S. Park, N. X. Nhiem, L. Subedi, I. Oh, J. Y. Kim, S. Y. Kim and S. H. Kim (2020). Isolation of bioactive limonoids from the fruits of Melia azedarach, J. Asian Nat. Prod. Res. 22(9), 830–838
N. Wang, Y. Fan, C. M. Yuan, J. Song, Y. Yao, W. Liu, B. Gajendran, E. Zacksenhaus, Y. Li, J. Liu, X. J. Hao and Y. Ben-David (2019). Selective ERK1/2 agonists isolated from Melia azedarach with potent antileukemic activity, BMC Cancer 19, 764-772
M. H. Rezadoost, H. H. Kumleh and A. Ghasempour. Cytotoxicity and apoptosis induction in breast cancer, skin cancer and glioblastoma cells by plant extracts, Mol. Biol. Rep. 46, 5131–5142
S. C. Yang, P. J. Chung, C. M. Ho, C. Y. Kuo, M. F. Hung, Y. T. Huang, W. Y. Chang, Y. W. Chang, K. H. Chan and T. L. Hwang (2013). Propofol inhibits superoxide production, elastase release, and chemotaxis in formyl peptide-activated human neutrophils by blocking formyl peptide receptor 1, J. Immunol. 190, 6511– 6519
H. P. Yu, P. W. Hsieh, Y. J. Chang, P. J. Chung, L. M. Kuo and T. L. Hwang (2011). 2-(2- Fluorobenzamido)benzoate ethyl ester (EFB-1) inhibits superoxide production by human neutrophils and attenuates hemorrhagic shock-induced organ dysfunction in rats, Free Radic. Biol. Med. 50, 1737–1748
A. I. Scott (1964). Interpretation Ultraviolet Spectra of Natural Products, 2nd ed., Pergamon Press, New York
M. Nakatani, T. Iwashita, K. Mizukawa and T. Hase (1987). Trichilinin, a new hexacyclic limonoid from Trichilia roka, Heterocycles 26, 43–46
M. Nakatani, M. Shimokoro, J. B. Zhou, H. Okamura, T. Iwagawa, K. Tadera, N. Nakayama and H. Naoki (1999). Limonoids from Melia toosendan, Phytochemistry 52, 709–714
K. Takeya, Z. S. Qiao, C. Hirobe, H. Itokawa (1996). Cytotoxic trichilin-type limonoids from Melia azedarach, Bioorg. Med. Chem. 4(8), 1355-1359
J. F. Hu, H. Fan, L. J. Wang, S. B. Wu, Y. Zhao (2011). Limonoids from the fruits of Melia toosendan, Phytochem. Lett. 4, 292–297
W. Aalbersberg, Y. Singh (1991). Dammarane triterpenoids from Dysoxylum richii, Phytochemistry 30(3), 921-926