Compounds 1, 3 and 5 expressed moderate cytotoxicity against two tested cell lines - MDA-MB-231 and RD (IC50 ranged from 34.19 to 74.25 μM), whereas compounds 4 and 6 exhibited selective cytotoxic activity (IC50 ranged from 29.07 to 45.20 μM).
📌 3 Maddede Bu Makale
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Amaç & Hipotez:Phytochemical investigations of the whole plants of Macrosolen bidoupensis Tangane & V.S.
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Temel Bulgular & Veri:Dang, a new species discovered in Viet Nam were conducted and led to the purification of ten compounds, comprising three lupane-type (1-3), three friedelane-type (4-6), and one glutinane-type (7) triterpenoids and three cholestane-type steroids (8-10) using various chromatographic methods.
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Sonuç & Katkı:Compounds 1, 3 and 5 expressed moderate cytotoxicity against two tested cell lines - MDA-MB-231 and RD (IC50 ranged from 34.19 to 74.25 μM), whereas compounds 4 and 6 exhibited selective cytotoxic activity (IC50 ranged from 29.07 to 45.20 μM).
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri
Özet
Phytochemical investigations of the whole plants of Macrosolen bidoupensis Tangane & V.S. Dang, a new species discovered in Viet Nam were conducted and led to the purification of ten compounds, comprising three lupane-type (1-3), three friedelane-type (4-6), and one glutinane-type (7) triterpenoids and three cholestane-type steroids (8-10) using various chromatographic methods. Their structures were characterized by HR-ESI-MS, NMR experiments and comparison with previous literature. Compounds 1, 3 and 5 expressed moderate cytotoxicity against two tested cell lines - MDA-MB-231 and RD (IC50 ranged from 34.19 to 74.25 μM), whereas compounds 4 and 6 exhibited selective cytotoxic activity (IC50 ranged from 29.07 to 45.20 μM).
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Bu Makaleye Atıf Yap
LE, K. H., NGUYEN, T. C., NGUYEN, T. A., NGUYEN, N. D. P., DO, T. H. T., NGUYEN, L. T. T., DANG, V. S., TRAN, T. D., PHAN, N. M., BUİ, T. D., MAİ, D. T., NGUYEN, T. P. (2021). Cytotoxic Activity and Phytochemical Constituents of Macrosolen bidoupensis Tangane & V.S. Dang. Records of Natural Products, Cilt: 15 - Sayı: 1, 71–75. https://ajindex.com/articles/308189
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