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Journals / Records of Natural Products / 2021 / Cilt: 15 - Sayı: 1

Cytotoxic Activity and Phytochemical Constituents of Macrosolen bidoupensis Tangane & V.S. Dang

Kieu Hung LE
Tran Canh NGUYEN
The Anh NGUYEN
Nu Dan Phuong NGUYEN
Thi Hong Tuoi DO
Le Thanh Tuyen NGUYEN
Van Son DANG
Trong Duc TRAN
Nhat Minh PHAN
Trong Dat BUİ
Dinh Tri MAİ
Tan Phat NGUYEN
Pages
71–75
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Compounds 1, 3 and 5 expressed moderate cytotoxicity against two tested cell lines - MDA-MB-231 and RD (IC50 ranged from 34.19 to 74.25 μM), whereas compounds 4 and 6 exhibited selective cytotoxic activity (IC50 ranged from 29.07 to 45.20 μM).

📌 3 Key Takeaways

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Objective & Hypothesis:Phytochemical investigations of the whole plants of Macrosolen bidoupensis Tangane & V.S.
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Key Findings & Data:Dang, a new species discovered in Viet Nam were conducted and led to the purification of ten compounds, comprising three lupane-type (1-3), three friedelane-type (4-6), and one glutinane-type (7) triterpenoids and three cholestane-type steroids (8-10) using various chromatographic methods.
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Conclusion & Impact:Compounds 1, 3 and 5 expressed moderate cytotoxicity against two tested cell lines - MDA-MB-231 and RD (IC50 ranged from 34.19 to 74.25 μM), whereas compounds 4 and 6 exhibited selective cytotoxic activity (IC50 ranged from 29.07 to 45.20 μM).
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Phytochemical investigations of the whole plants of Macrosolen bidoupensis Tangane & V.S. Dang, a new species discovered in Viet Nam were conducted and led to the purification of ten compounds, comprising three lupane-type (1-3), three friedelane-type (4-6), and one glutinane-type (7) triterpenoids and three cholestane-type steroids (8-10) using various chromatographic methods. Their structures were characterized by HR-ESI-MS, NMR experiments and comparison with previous literature. Compounds 1, 3 and 5 expressed moderate cytotoxicity against two tested cell lines - MDA-MB-231 and RD (IC50 ranged from 34.19 to 74.25 μM), whereas compounds 4 and 6 exhibited selective cytotoxic activity (IC50 ranged from 29.07 to 45.20 μM).

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Cite This Article

LE, K. H., NGUYEN, T. C., NGUYEN, T. A., NGUYEN, N. D. P., DO, T. H. T., NGUYEN, L. T. T., DANG, V. S., TRAN, T. D., PHAN, N. M., BUİ, T. D., MAİ, D. T., NGUYEN, T. P. (2021). Cytotoxic Activity and Phytochemical Constituents of Macrosolen bidoupensis Tangane & V.S. Dang. Records of Natural Products, Cilt: 15 - Sayı: 1, 71–75. https://ajindex.com/articles/308189

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