Cytotoxic Diterpenoids from Scoparia dulcis

Objective & Hypothesis:A new scopadulane-type diterpenoid (1) and one known labdane-type diterpenoid (2) have been isolated from the whole plants of a traditional medicinal plant, Scoparia dulcis.

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Key Findings & Data:Their structures were established mainly by spectroscopic methods, and the absolute configuration of compound 1 has been determined by quantum chemical calculation of the electronic circular dichroism (ECD) spectrum and comparison with the experimental one.

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Conclusion & Impact:In addition, compound 2 also showed in vitro anti-tumor activity against MCF-7, MDA-MB231, and Hela cells in a concentration-dependent manner.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

A new scopadulane-type diterpenoid (1) and one known labdane-type diterpenoid (2) have been isolated from the whole plants of a traditional medicinal plant, Scoparia dulcis. Their structures were established mainly by spectroscopic methods, and the absolute configuration of compound 1 has been determined by quantum chemical calculation of the electronic circular dichroism (ECD) spectrum and comparison with the experimental one. The cytotoxicity of 1 and 2 against two breast cancer cell lines (MCF-7 and MDA-MB231) and a cervical cancer cell line (Hela) were tested, and only compound 2 displayed inhibitory activities against these cells with IC50 values ranging from 8.1 to 45.2 M, while compound 1 were inactive. In addition, compound 2 also showed in vitro anti-tumor activity against MCF-7, MDA-MB231, and Hela cells in a concentration-dependent manner.

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Cite This Article

WANG, L., YU, J., NIE, Z., SHAN, P. (2022). Cytotoxic Diterpenoids from Scoparia dulcis. Records of Natural Products, Cilt: 16 - Sayı: 5, 454–462. https://ajindex.com/articles/588787

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