SavedAdd your journal

Journals / Records of Natural Products / 2022 / Cilt: 16 - Sayı: 4

A New Short Chain Acetamide from the Biosphere and Bioactive Glycerolipids Extracted from the Marine Bibalve Codakia orbicularis (Lucinidae)

Olivier GROVEL
Ali Al-MOURABİT
Céline MORIOU
Francesca GOUDOU
Olivier GROS
Philippe PETİT
Pages
370–375
Publication Date
2022-10-19
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Further investigations are currently in progress, so as to understand the role of these bioactive compounds into the regulation of C. orbicularis’ endosymbionts and/or to free-living pathogens.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The marine bivalve Codakia orbicularis, harbors endosymbiotic bacteria located in its gill filaments.
📊
Key Findings & Data:The fraction eluted in AcOEt/ MeOH 90:10 displayed the greatest bioactivity.
💡
Conclusion & Impact:Further investigations are currently in progress, so as to understand the role of these bioactive compounds into the regulation of C. orbicularis’ endosymbionts and/or to free-living pathogens.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The marine bivalve Codakia orbicularis, harbors endosymbiotic bacteria located in its gill filaments. Bioassay-guided fractionation of an ethyl acetate extract of the gill tissues led to antibacterial fractions (against Gram positive and negative bacteria). The fraction eluted in AcOEt/ MeOH 90:10 displayed the greatest bioactivity. This fraction was analyzed using usual chromatographic and spectrometric methods and revealed three compounds. The first one (compound 1) was an acetamide isolated for the first time from the biosphere. The other two were mono-glycerolipids (compound 2) and (compound 3) with at the position sn-2 of their glycerol monounsaturated fatty acid chains (respectively C18:1Δ9 and C16:1Δ9). Compounds 2 and 3 showed bacteriostatic activity against two pathogenic Gram-negative bacteria using a disc diffusion assay method. These molecules have been isolated for the first time from a bivalve. Further investigations are currently in progress, so as to understand the role of these bioactive compounds into the regulation of C. orbicularis’ endosymbionts and/or to free-living pathogens.

🔖

Cite This Article

GROVEL, O., Al-MOURABİT, A., MORIOU, C., GOUDOU, F., GROS, O., PETİT, P. (2022). A New Short Chain Acetamide from the Biosphere and Bioactive Glycerolipids Extracted from the Marine Bibalve Codakia orbicularis (Lucinidae). Records of Natural Products, Cilt: 16 - Sayı: 4, 370–375. https://ajindex.com/articles/588786

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. C. J. Berg, J. Krzynowek, P. Atalo and K. Wiggin (1985). Sterol and fatty acid composition of the clam, Codakia orbicularis, with chemoautotrophic symbionts, Lipids 20,116–120
  2. L. Frenkiel and M. Mouëza (1995). Gill ultrastructure and symbiotic bacteria in Codakia orbicularis (Bivalvia, Lucinidae), Zoomorphology 115, 51–61
  3. O. Gros, A. Darrasse, P. Durand, L. Frenkiel and M. Mouëza (1996). Environmental transmission of a sulfur-oxidizing bacterial gill endosymbiont in the tropical lucinid bivalve Codakia orbicularis, Appl. Environ. Microbiol. 62, 2324–2330
  4. A. Caro, O. Gros, P. Got, R. De Wit and M. Troussellier (2007). Characterization of the population of the sulfur-oxidizing symbiont of Codakia orbicularis (Bivalvia, Lucinidae) by single-cell analyses, Appl. Environ. Microbiol. 73, 2101–2109
  5. A. Caro, P. Got, M. Bouvy, M. Troussellier and O. Gros (2009). Effects of long-term starvation on a host bivalve (Codakia orbicularis, Lucinidae) and its symbiont population, Appl. Environ. Microbiol. 75, 3304–3313
  6. J. P. Gourdine and E. J. Smith-Ravin (2007). Analysis of a cDNA-derived sequence of a novel mannosebinding lectin, codakine, from the tropical clam Codakia orbicularis, Fish Shellfish Immunol. 22, 498– 509
  7. F. Goudou, P. Petit, C. Moriou, O. Gros and A. Al-Mourabit (2017). Orbicularisine: a new spiro-indolothiazine skeleton isolated from gills of the tropical bivalve Codakia orbicularis, J. Nat. Prod. 80, 1693– 1696
  8. F. Goudou, A. Al-Mourabit, C. Moriou, P. Dumesnil, O. Gros and P. Petit (2019). Acetylated nucleoside derivatives isolated from a shallow-water marine bivalve Codakia orbicularis, Chem. Nat. Compd. 55, 790–792
  9. T. Brinkhoff, G. Bach, T. Heidorn, L. Liang, A. Schlingloff and M. Simon (2004). Antibiotic production by a Roseobacter clade-affiliated species from the german wadden sea and its antagonistic effects on indigenous isolates, Appl. Environ. Microbiol. 70, 2560–2565
  10. V.P. Careaga and M.S. Maier (2014). Cerebrosides from marine organisms, Stud. Nat. Prod. Chem. 42, 59–81
  11. J. S. O’Brien and G. Rouser (1964). The fatty acid composition of brain sphingolipids: sphingomyelin, ceramide, cerebroside, and cerebroside sulfate, J. Lipid Res. 5, 339–342
  12. H. Van Overloop, Y. Denizot, M. Baes and P. P. Van Veldhoven (2007). On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase, Biol. Chem. 388, 315–324
  13. W.W. Nawa