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Journals / Records of Natural Products / 2020 / Cilt: 14 - Sayı: 1

Two Novel Sesquiterpenes and A New Pregnane Derivative from the South China Sea Gorgonian Subergorgia suberosa

Xian Qiang CHEN
Nannan XİNG
Bin YANG
Xuefeng ZHOU
Chenghai GAO
Yonghong LIU
Pages
57–64
Publication Date
2022-10-19
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The discovery of isosuberosenol A (1) provides some strong support for the plausible biogenetic pathway of quadrone type sesquiterpenes.

📌 3 Key Takeaways

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Objective & Hypothesis:Two novel sequiterpenes isosuberosenol A (1), suberosain A (2), and a new pregnane derivative 4- hydroxymethyl-5β-pregnan-3, 20-dione (3) have been isolated from the South China Sea gorgonian Subergorgia suberosa.
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Key Findings & Data:Their structure and relative stereochemistry were established based on the detailed spectroscopic analysis, including HR-ESI-MS, 1D- and 2D NMR spectra.
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Conclusion & Impact:The discovery of isosuberosenol A (1) provides some strong support for the plausible biogenetic pathway of quadrone type sesquiterpenes.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Two novel sequiterpenes isosuberosenol A (1), suberosain A (2), and a new pregnane derivative 4- hydroxymethyl-5β-pregnan-3, 20-dione (3) have been isolated from the South China Sea gorgonian Subergorgia suberosa. Their structure and relative stereochemistry were established based on the detailed spectroscopic analysis, including HR-ESI-MS, 1D- and 2D NMR spectra. The skeleton of isosuberosenol A (1) have been previously undescribed. The discovery of isosuberosenol A (1) provides some strong support for the plausible biogenetic pathway of quadrone type sesquiterpenes.

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Cite This Article

CHEN, X. Q., XİNG, N., YANG, B., ZHOU, X., GAO, C., LIU, Y. (2022). Two Novel Sesquiterpenes and A New Pregnane Derivative from the South China Sea Gorgonian Subergorgia suberosa. Records of Natural Products, Cilt: 14 - Sayı: 1, 57–64. https://ajindex.com/articles/588789

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References (13)

  1. G. Amiram, F. William, C.H. He, C. Jon, Z. Wu, Z. Yiao and K. Long (1985). Subergorgic acid, a novel tricyclopentanoid cardiotoxin from the pacific gorgonian coral, Tetrahedron Lett. 26, 2379-2382
  2. S.H. Qi, S. Zhang, X. Li and Q.X. Li (2005). A cytotoxic sesquiterpene alkaloid from the South China Sea gorgonian Subergorgia suberosa, J. Nat. Prod. 68, 1288-1289
  3. G.H. Wang, A.F. Ahmed, Y.H. Kuo and J.H. Sheu (2002). Two new subergane-based sesquiterpenes from a Taiwanese gorgonian coral Subergorgia suberosa, J. Nat. Prod. 65, 1033-1036
  4. M.W. Xu and Y.T. Hao (2016). A new sesquiterpene from the South China Sea gorgonian coral Subergorgia suberosa, Nat. Prod. Res. 30, 2402-2406
  5. G.H. Wang, A.F. Ahmed, J.H. Sheu, C.Y. Duh, Y.C. Shen and L.T. Wang (2002). Suberosols A−D, four new sesquiterpenes with β-caryophyllene skeletons from a Taiwanese gorgonian coral Subergorgia suberosa, J. Nat. Prod. 65, 887-891
  6. P.S. Parameswaran, C.G. Naik, S.Y. Kamat, M.S. Puar, P. Das and V.R. Hegde (1998). Studies on the secondary metabolites from the Indian gorgonian Subergorgia suberosa: Isolation and characterization of four analogues of the cardiotoxin subergorgic acid, J. Nat. Prod. 61, 1074-1074
  7. S. Qi, S. Zhang, L. Yang and P. Qian (2008). Antifouling and antibacterial compounds from the gorgonians Subergorgia suberosa and Scripearia gracillis, Nat. Prod. Res. 22, 154-166
  8. W. Cheng, J. Ren, Q. Huang, H. Long, H. Jin, L. Zhang, H. Liu, L. van Ofwegen and W. Lin (2016). Pregnane steroids from a gorgonian coral Subergorgia suberosa with anti-flu virus effects, Steroids 108, 99-104
  9. S. Qi, S. Zhang, Y. Wang and M. Li (2007). Complete 1H and 13C NMR assignments of three new polyhydroxylated sterols from the South China Sea gorgonian Subergorgia suberosa, Magn. Reson. Chem. 45, 1088-1091
  10. J. Zhang, L.L. Liu, B.L. Zhong, X.J. Liao and S.H. Xu (2015). 9,11-Secosteroids with cytotoxic activity from the South China Sea gorgonian coral Subergorgia suberosa, Steroids 98, 100-106
  11. M. Liu, C.L. Shao, M. Chen, J. Qi, Y. Wang, Y.C. Fang and C.Y. Wang (2014). Bioactive 9,11-secosteroids from gorgonian Subergorgia suberosa collected from the South China sea, Chem. Biodivers. 11, 1109-1120
  12. S.H. Qi, S. Zhang and H. Huang (2008). Purine alkaloids from the South China Sea gorgonian Subergorgia suberosa, J. Nat. Prod. 71, 716-718
  13. H. Bokesch, T. McKee and J. Cardellina (1996). Suberosenone, a new cytotoxin from Subergorgia suberosa, Tetrahed