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Dergiler / Records of Natural Products / 2022 / Cilt: 16 - Sayı: 5

Cytotoxic Diterpenoids from Scoparia dulcis

Lirong WANG
Jie YU
Zonglong NIE
Peipei SHAN
Sayfa
454–462
Yayın Tarihi
2022-10-19
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

In addition, compound 2 also showed in vitro anti-tumor activity against MCF-7, MDA-MB231, and Hela cells in a concentration-dependent manner.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:A new scopadulane-type diterpenoid (1) and one known labdane-type diterpenoid (2) have been isolated from the whole plants of a traditional medicinal plant, Scoparia dulcis.
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Temel Bulgular & Veri:Their structures were established mainly by spectroscopic methods, and the absolute configuration of compound 1 has been determined by quantum chemical calculation of the electronic circular dichroism (ECD) spectrum and comparison with the experimental one.
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Sonuç & Katkı:In addition, compound 2 also showed in vitro anti-tumor activity against MCF-7, MDA-MB231, and Hela cells in a concentration-dependent manner.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

A new scopadulane-type diterpenoid (1) and one known labdane-type diterpenoid (2) have been isolated from the whole plants of a traditional medicinal plant, Scoparia dulcis. Their structures were established mainly by spectroscopic methods, and the absolute configuration of compound 1 has been determined by quantum chemical calculation of the electronic circular dichroism (ECD) spectrum and comparison with the experimental one. The cytotoxicity of 1 and 2 against two breast cancer cell lines (MCF-7 and MDA-MB231) and a cervical cancer cell line (Hela) were tested, and only compound 2 displayed inhibitory activities against these cells with IC50 values ranging from 8.1 to 45.2 M, while compound 1 were inactive. In addition, compound 2 also showed in vitro anti-tumor activity against MCF-7, MDA-MB231, and Hela cells in a concentration-dependent manner.

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Bu Makaleye Atıf Yap

WANG, L., YU, J., NIE, Z., SHAN, P. (2022). Cytotoxic Diterpenoids from Scoparia dulcis. Records of Natural Products, Cilt: 16 - Sayı: 5, 454–462. https://ajindex.com/articles/588787

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Kaynakça (14)

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