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Journals / Records of Natural Products / 2022 / Cilt: 16 - Sayı: 4

Fissistigmol A: A New Polyacetylene alcohol from Fissistigma Minuticalyx

Weifeng DAI
Ping YANG
Ji SONG
Shiyun JIAO
Mi ZHANG
Pages
382–386
Publication Date
2022-10-19
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

In addition, bioactivity assay showed that 1-5 showed notable nitric oxide (NO) inhibitory effects (IC50 < 10 μM) on the model of the lipopolysaccharide (LPS)-activated RAW 264.7 macrophages.

📌 3 Key Takeaways

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Objective & Hypothesis:A new polyacetylene alcohol, Fissistigmol A (1), along with four known polyacetylene alcohol compounds (2-5) were isolated from the aerial part of Fissistigma minuticalyx (McGr. et W.
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Key Findings & Data:Their structures were elucidated based on the spectroscopic evidence, mainly including NMR and induced ECD, and HRESIMS data.
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Conclusion & Impact:In addition, bioactivity assay showed that 1-5 showed notable nitric oxide (NO) inhibitory effects (IC50 < 10 μM) on the model of the lipopolysaccharide (LPS)-activated RAW 264.7 macrophages.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

A new polyacetylene alcohol, Fissistigmol A (1), along with four known polyacetylene alcohol compounds (2-5) were isolated from the aerial part of Fissistigma minuticalyx (McGr. et W. W. Sm.). Their structures were elucidated based on the spectroscopic evidence, mainly including NMR and induced ECD, and HRESIMS data. In addition, bioactivity assay showed that 1-5 showed notable nitric oxide (NO) inhibitory effects (IC50 < 10 μM) on the model of the lipopolysaccharide (LPS)-activated RAW 264.7 macrophages.

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Cite This Article

DAI, W., YANG, P., SONG, J., JIAO, S., ZHANG, M. (2022). Fissistigmol A: A New Polyacetylene alcohol from Fissistigma Minuticalyx. Records of Natural Products, Cilt: 16 - Sayı: 4, 382–386. https://ajindex.com/articles/588736

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