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Journals / İstanbul Üniversitesi İstanbul Tıp Fakültesi Mecmuası / 2004 / Cilt: 67 - Sayı: 3

Evaluation of the imbalance between antioxidant activity and lipid peroxidation in preeclamptic patients

Preeklamptik hastalarda antioksidan aktivite ve lipid peroksidasyonu arasındaki dengenin irdelenmesi

Gülbu IŞITMANGİL
Yasemin BUDAK
Şebnem İNAL
Pages
149–152
Publication Date
2022-10-17
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The findings in this study show that there is an imbalance between antioxidant defences and lipid peroxidation in preeclamptic patients.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Evaluation of the imbalance between antioxidant activity and lipid peroxidation in preec-lamptic patients.
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Key Findings & Data:The objective of this study is to test the hypothesis that maternal plasma lipid peroxidation products are increased and antioxidants are decreased in women with mild pre-eclampsia.
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Conclusion & Impact:The findings in this study show that there is an imbalance between antioxidant defences and lipid peroxidation in preeclamptic patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Evaluation of the imbalance between antioxidant activity and lipid peroxidation in preec-lamptic patients. The objective of this study is to test the hypothesis that maternal plasma lipid peroxidation products are increased and antioxidants are decreased in women with mild pre-eclampsia. Fasting venous plasma were collected from normal pregnant (n=16) and mild pre-eclamptic women (n=16). Plasma total antioxidant status and thiobarbituric acid reactive substances (TBARS) were measured by colorimetric assay. Plasma maternal concentrations of total antioxidant status and thiobarbituric acid reactive substances (TBARS) were not significantly different in pre-eclampsia as compared with normal pregnancy (p> 0.05). When the variables in the same groups were measured, we found a negative correlation between total antioxidant status and TBARS in the normal group (r= -0.60, p0.05). The findings in this study show that there is an imbalance between antioxidant defences and lipid peroxidation in preeclamptic patients.

Özet

Bu çalışmanın amacı preeklamptik gebelerde kan lipid peroksidasyon ürünlerinin artması ve antioksidan düzeylerinin azalması ile ilgili hipotezi araştırmaktır. Bu amaçla normal gebe (n=16) ve preeklamptik gebelerden (n=16) açlık venöz kanı alındı. Plazma total antioksidan aktivite ve tiyobarbitürik asitle reaksiyona giren maddelerin (TBARS) düzeyleri kolorimetrik yöntemle ölçüldü. Çalışmanın bulgularına göre normal ve preeklamptik hamilelerin plazma total antioksidan aktivite değerleri ve TBARS değerleri arasında istatistiksel olarak anlamlı bir fark bulunamadı. Ayrıca sağlıklı gebe kadınlardan oluşan grupta total antioksidan aktivite ve TBARS değerleri arasında negatif yönde, orta güçte bir korelasyon tespit edildi (r=-0.60, p0.05). Bu bulgular ışığında preeklamptik hastalarda antioksidan savunma sistemleri ve lipid peroksidasyonu arasında bir dengesizlik olduğu ileri sürülebilir.

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Cite This Article

IŞITMANGİL, G., BUDAK, Y., İNAL, Ş. (2022). Evaluation of the imbalance between antioxidant activity and lipid peroxidation in preeclamptic patients. İstanbul Üniversitesi İstanbul Tıp Fakültesi Mecmuası, Cilt: 67 - Sayı: 3, 149–152. https://ajindex.com/articles/553656

References (17)

  1. Ames BN, Shigensaga MK, Hagen TM: Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA. 1993; 90: 7915
  2. Bowen R. S, Moodley J, Dutton F.M, Theron J.A: Oxidative stress in pre-eclarripsia. Acta Obs Gyn Scand. 2001; 80: 719
  3. Cunningham FG, Lindheimer MD: Hypertension in pregnancy: Current concepts. N Eng J Med 1992; 326: 927
  4. Davidge ST. Hubel CA, Braydm RD, Capeless EC, MeLaughlin MK: Sera antioxidant activity in uncomplicated and preeclamptic pregnancies. Obstet Gynecol 1992; 79: 897
  5. Gitto E, Reiter RJ, Karbownik M, Tan D, Gitto P, Barberi S, Barberi I: Causes of oxidative stress in the pre- and perinatal period. Biol Neonate 2002; 81:146
  6. Gu Heridge JMC, Halliwell B: The measurement and mechanism of lipid peroxidation in biological systems. Trends Biochem Sci 1990; 15:12
  7. Halliwell B, Gutteridge JMC, Cross CE: Free radicals, antioxidants, and human disease: where are we now? J Clin Lab Med 1992; 119:598
  8. Hubel CA: Oxidative stress in the pathogenesis of preeclampsia. Exp Biol Med 1999; 222: 222
  9. Kaneko T, Nakono S, Matsuo M: Protective effect of vitamin E on linoleic acid hydroperoxide-induced injury to human endothelial cells. Lipids 1991; 26:345
  10. Kaunitz AM, Hughes JM, Brimes DA, Smith JC, Rochat RW, Kafrissen ME: Causes of maternal mortality in the United States. Obst Gynecol 1985; 65: 605
  11. Kharb S: Total free radical trapping antioxidant potential in pre-eclampsia. Int J Gynaecol 2000; 69: 23
  12. Madazli R, Benian A, Gumustas K, Uzun H, Ocak V, Aksu F: Lipid peroxidation and antioxidants in preeclampsia. Eur J Obstet Gynecol Reprod Biol 1999; 85: 205
  13. Magann E, Martin J, Isaacs J, Perry K, Martin R, Meydrech E: Immediate postpartum curettage: Accelerated recovery from severe preeclampsia. Obstet Gynecol. 1993; 81: 502
  14. Miller NJ, Rice-Evans C, Davies MJ, Gopinathan V, Milner A: A novel method for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clin Sci 1993; 84: 407
  15. Miller NJ, Sampson J, Candeias LP, Bramley PM, Rice-Evans CA: Antioxidant activities of carotenes and xanthophylls. FEBS Lett. 1996; 384: 240 (1996)
  16. Morris JM, Gopaul NK, Endresen MJR Knight M, Linton EA, Dhir S, Anggard EE, Redmon CWG: Circulating markers of oxidative stress are raised in normal pregnancy and preeclampsia. Br J Obs Gyn 1998; 105: 1195
  17. Poston L, Chappell LC: Is oxidative stress involved in the aetiology of pre-eclampsi