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Journals / Online Türk Sağlık Bilimleri Dergisi / 2020 / Cilt: 5 - Sayı: 4

A Preliminary Research on HLA-Association of Lumbar Spinal Stenosis

Lomber Spinal Stenozun HLA İlişkisi Üzerine Ön Araştırma

Mustafa EFENDİOĞLU
Ezgi AKAR
Emine Emel KOÇMAN
Recep BAŞARAN
Gülbu IŞITMANGİL
Pages
683–692
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

HLA A2, HLA B44, and HLA C6 alleles have been determined as predisposing factors for LSS.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: We aim to identify the relationship lumbar spinal stenosis (LSS) and genetic HLA system.Materials and Methods: The present study investigates 15 cases out of 41 (7 male, 8 female; average age: 60.27) who were studied for HLA class I ABC genes, as well as totally 41 cases (19 male; 22 female; average age: 60.46) who were studied for HLA class II DR.DQB1 genes among the cases with LSS.
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Key Findings & Data:Allele identification was made using the official HLA Nomenclature Committee software.Results: HLA A2 allele in LSS group (%36.7) is statistically significantly higher than control group (%17.2) (p:0.039; p<0.05).
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Conclusion & Impact:HLA A2, HLA B44, and HLA C6 alleles have been determined as predisposing factors for LSS.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Human lökosit antijen · lomber spinal stenosis · sınıf I/II genler

Abstract

Objective: We aim to identify the relationship lumbar spinal stenosis (LSS) and genetic HLA system.Materials and Methods: The present study investigates 15 cases out of 41 (7 male, 8 female; average age: 60.27) who were studied for HLA class I ABC genes, as well as totally 41 cases (19 male; 22 female; average age: 60.46) who were studied for HLA class II DR.DQB1 genes among the cases with LSS. DNA extraction, the DNA was amplified with primers specific to HLA-A, B, C, DQ and DR, and studied using the SSP-PCR method. Allele identification was made using the official HLA Nomenclature Committee software.Results: HLA A2 allele in LSS group (%36.7) is statistically significantly higher than control group (%17.2) (p:0.039; p<0.05). The frequency of the B44 allele was statistically significantly higher in the LSS group (20%) than in the control group (5.1%) (p:0.010; p<0.05). Likewise, the frequency of the C6 allele was statistically significantly higher in the LSS group (26.7%) than in the control group (8.6%) (p:0.013; p<0.05). Conclusion: This preliminary study has suggested that LSS is associated with HLA class I genes. HLA A2, HLA B44, and HLA C6 alleles have been determined as predisposing factors for LSS.

Özet

Amaç: Biz bu çalışmada lumbar spinal stenosis (LSS) ile genetik HLA sistemi arasındaki ilişkiyi tespit etmeyi amaçladık.

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Cite This Article

EFENDİOĞLU, M., AKAR, E., KOÇMAN, E. E., BAŞARAN, R., IŞITMANGİL, G. (2020). A Preliminary Research on HLA-Association of Lumbar Spinal Stenosis. Online Türk Sağlık Bilimleri Dergisi, Cilt: 5 - Sayı: 4, 683–692. https://ajindex.com/articles/293892

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