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Journals / Bezm-i Alem Valide Sultan SSK Vakıf Gureba Eğitim Hastanesi Derg. / 2005 / Cilt: 3 - Sayı: 1

Antibodies in aqueous humor and serum in patients with ocular toxoplasmosis

Oküler toksoplazmozlu vakalarda ön kamara sıvısı ve serumda antikor değerleri

Oğuzhan SAYGILI
Eftal YÖRÜK
Pages
9–12
Publication Date
2022-10-11
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The determination of toxoplasma antibodies in the patients'serum is of limited value.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The diagnosis of ocular toxoplasmosis is mainly-based on ophlhalmological examination but might be diffi­cult in some cases.
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Key Findings & Data:Study design: Retrospective clinical trial Materials & methods: Specific IgG in aqueous humor and serum samples from 50 patients with toxoplasmic retinochoroiditis, with 25 patients with uveitis posterior or panuveitis serving as controls.
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Conclusion & Impact:The determination of toxoplasma antibodies in the patients'serum is of limited value.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The diagnosis of ocular toxoplasmosis is mainly-based on ophlhalmological examination but might be diffi­cult in some cases. The purpose of our study was to evalu­ate the value of aqueous humor and serum analysis in ocu­lar toxoplasmosis. Study design: Retrospective clinical trial Materials & methods: Specific IgG in aqueous humor and serum samples from 50 patients with toxoplasmic retinochoroiditis, with 25 patients with uveitis posterior or panuveitis serving as controls. Results: Specific intraocular antibody synthesis could be confirmed in 49 patients (98%). In two patients (8%) of the control group, antibody synthesis was detected. Forty-nine patients with diagnosis of ocular Toxoplasmosis were po­sitive for serum anti-T.gondii IgG, but only three patients had increased IgM levels. Conclusion: Analysis of local antibody production is a reliable method for confirming or excluding a suspected clinical diagnosis of toxoplasma retinochoroiditis. The determination of toxoplasma antibodies in the patients'serum is of limited value.

Özet

Amaç: Oküler Toksoplazmoz tanısı oftalmolojik muaye­neye dayanır. Fakat sadece klinik değerlendirme tanıda bazen zorluklara yol açabilir. Çalışmamızın amacı oküler Toksoplazmoz vakalarında, ön kamara sıvısı ve serum antikor seviyelerinin diagnostik değerini tespit etmekti. Çalışma düzeni: Relrospektif klinik çalışma Gereç ve yöntem: Klinik olarak Toksoplazmoz düşünülen 50 hasta ile posterior üveit veya panuveitis (kontrol grubu) tanılı 25 hastada, ön kamara sıvısı ve serumda Toksoplaznıa gondii antikoru incelendi. Bulgular: Toksoplazmoz-Rctinokoroidit düşünülen 49 hastada inlraoküler antikor sente/i ispatlandı. Kontrol grubunda ise 2 hastada lokal antikor üretimi görüldü. Oküler Toksoplazmozlu 50 hastadan 49'u yüksek serum IgG-antikor tilresi gösterdi, 47'si ise IgM negatifti. Kontrol grubunda 21 hastada serum IgG yüksek, fakat IgM negatifti. Sonuç: Lokal antikor tespiti Toksoplazmoz-Relinokoroidit tanısında güvenilir bir metoddur. Serum analizi ise fa/la anlamlı değildir.

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Cite This Article

SAYGILI, O., YÖRÜK, E. (2022). Antibodies in aqueous humor and serum in patients with ocular toxoplasmosis. Bezm-i Alem Valide Sultan SSK Vakıf Gureba Eğitim Hastanesi Derg., Cilt: 3 - Sayı: 1, 9–12. https://ajindex.com/articles/464185

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