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Journals / Atatürk Üniversitesi Veteriner Bilimleri Dergisi / 2016 / Cilt: 11 - Sayı: 1

Comparison of the Therapeutic Effects of Antibiotic, Steroid, and Vitamin K During Early Sepsis in Laboratory Animals

Antibiyotik, Steroid ve Vitamin K’nın Terapötik Etkilerinin Erken Dönem Sepsis Süresince Laboratuvar Hayvanlarında Karşılaştırılması

Seckin OZKANLAR
Zekai HALICI
Muhammet Hamidullah UYANIK
Fatih AKCAY
Pages
13–21
Publication Date
2022-10-11
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The platelet count decreased in Group CLP and CLP+MP (P

📌 3 Key Takeaways

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Objective & Hypothesis:The use of corticosteroids alone or with antibiotics in the treatment of sepsis is still a subject of conflict.
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Key Findings & Data:Rats were divided into 7 groups including 12 rats each.
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Conclusion & Impact:The platelet count decreased in Group CLP and CLP+MP (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The use of corticosteroids alone or with antibiotics in the treatment of sepsis is still a subject of conflict. Besides, coagulation abnormalities in sepsis ranging from bleeding to microvascular thrombosis are needed to be evaluated with respect to Vitamin K (Vit K) dependence. The effects of antibiotic, steroid and Vit K on severe sepsis were investigated to compare therapeutic outcomes in this study. Cecal-ligation-puncture (CLP) was induced by abdominal surgery in rats to produce septic peritonitis. Rats were divided into 7 groups including 12 rats each. Groups were Sham, CLP, CLP+IM (imipenem), CLP+MP (methylprednisolone), CLP+VK (vitamin K3, menadione), CLP+IM+MP and CLP+IM+VK. Six animals from each group were sacrificed to obtain samples at the 16th h. The remaining ones were observed to record survival times. The highest increases in serum TNF-α, IL-1β and IL-6 levels were observed in Group CLP and CLP+VK. Cytokines did not significantly increase in Group CLP+IM+MP. The platelet count decreased in Group CLP and CLP+MP (P

Özet

Sepsisin tedavisinde kortikosteroidlerin tek başına ya da antibiyotiklerle birlikte kullanımları halen anlaşılması güç bir konudur. Ayrıca, sepsiste kanamadan mikrovasküler tromboza kadar değişen koagülasyon anormalliklerinin Vitamin K (Vit K) bağımlılığı yönünden araştırılması gerekmektedir. Bu çalışmada antibiyotik, steroid ve Vit K'nın etkilerinin terapötik sonuçları şiddetli sepsiste araştırılmıştır. Sıçanlarda septik peritonitis oluşturmak için abdominal cerrahi ile çekal-bağlamadelme (CLP) yapıldı. Sıçanlar her grupta 12 sıçan olmak üzere 7 gruba ayrıldı. Gruplar Sham, CLP, CLP+IM (imipenem), CLP+MP (metilprednizolon), CLP+VK (vitamin K3, menadione), CLP+IM+MP ve CLP+IM+VK'dir. Her gruptan 6 hayvan 16'ncı saatte örneklerin elde edilmesi için sakrifiye edildi. Kalan hayvanlar yaşam sürelerinin kaydedilebilmesi için gözlemlendi. TNF-?, IL-1? ve IL-6 değerlerindeki en yüksek artış CLP ve CLP+VK gruplarında görüldü. Sitokinler CLP+IM+MP grubunda önemli derecede artmadı. Trombosit sayısı CLP ve CLP+MP gruplarında azaldı (P

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Cite This Article

OZKANLAR, S., HALICI, Z., UYANIK, M. H., AKCAY, F. (2022). Comparison of the Therapeutic Effects of Antibiotic, Steroid, and Vitamin K During Early Sepsis in Laboratory Animals. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, Cilt: 11 - Sayı: 1, 13–21. https://ajindex.com/articles/455865

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