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Journals / Veterinary Sciences and Practices / 2026 / Cilt: 10 Sayı: 1

Efficacy of Amphotericin-B, Clinicopathologic Variables and Oxidative Stress Markers in three Staffordshire Bull Terrier Dogs with Visceral Leishmaniasis

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Basak Hanedan
Mehmet Borku
Yunusemre Ozkanlar
Ali Haydardedeoglu
Serkal Gazyagcı
Ahmet Aydın
Seckin Ozkanlar
Pages
—
Publication Date
2015-04-09
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It was concluded that 4-month of AMB administration may be effective to treat VL due to no clinical recurrence for six months follow-up.

📌 3 Key Takeaways

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Objective & Hypothesis:This study was aimed at evaluating the effects of Leishmania infection and AMB (amphotericin-B) treatment on hematological, biochemical and oxidative stress parameters in three Staffordshire Bull Terrier dogs with visceral leishmaniasis (VL).
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Key Findings & Data:AMB was administered to cases with VL at a dose of 0.6 to 1.5 mg/kg/week for four months.
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Conclusion & Impact:It was concluded that 4-month of AMB administration may be effective to treat VL due to no clinical recurrence for six months follow-up.
🔬Design:Makale
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

This study was aimed at evaluating the effects of Leishmania infection and AMB (amphotericin-B) treatment on hematological, biochemical and oxidative stress parameters in three Staffordshire Bull Terrier dogs with visceral leishmaniasis (VL). These dogs were presented with weight loss, weakness, and cutaneous lesions. Canine kala-azar detect kit was positive in dogs with VL. AMB was administered to cases with VL at a dose of 0.6 to 1.5 mg/kg/week for four months. Leishmania agents caused the liver injury in cases 1 and 2 due to increase in ALT level, decrease in erythrocyte, hemoglobin, and hematocrit level and increase in MDA, and decrease in GSH-Px in case 3 and did not affect the kidney functions due to normal urea and creatinine level in the dogs with VL. A gradual response to the administration of AMB was observed. At the end of treatment course, cases with VL were cured clinically. It was concluded that 4-month of AMB administration may be effective to treat VL due to no clinical recurrence for six months follow-up.

Özet

Bu çalışmada visseral Leishmaniasis’li (VL) üç Staffordshire Bull Terrier köpekte Leishmania enfeksiyonu ve AMB (amfoterisin-­‐B) tedavisinin hematolojik, biyokimyasal ve oksidatif stres parametreleri üzerine etkilerini değerlendirmek amaçlandı. Bu köpekler kilo kaybı, halsizlik ve deri lezyonları ile kliniğe getirildi. Kanin kala-­‐azar test kiti VL’li köpeklerde pozitifti. Visseral Leishmaniasis’li olgulara AMB 0.6-­‐1.5 mg/kg/hafta dozunda 4 ay süre ile uygulandı. Leishmania etkenleri olgu 1 ve 2’de ALT düzeyinde artışa bağlı olarak karaciğer hasarına, olgu 3’te eritrosit, hemoglobin ve hematokrit düzeyde azalmaya ve MDA’da artışa ve GSH-­‐Px’de azalmaya neden oldu fakat VL’li köpeklerde normal üre ve kreatinin düzeyine bağlı olarak böbrek fonksiyonlarını etkilemedi. AMB tedavisine kademeli yanıt gözlendi. Tedavi seyrinin sonunda VL’li olgular klinik olarak iyileşti. Sonuç olarak 6 ay süre ile takipte klinik nüks olmamasına bağlı olarak visseral Leishmaniasis’i tedavi etmek için 4 ay süreli AMB uygulamasının etkili olabileceği kanısına varıldı.

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Cite This Article

Hanedan, B., Borku, M., Ozkanlar, Y., Haydardedeoglu, A., Gazyagcı, S., Aydın, A., Ozkanlar, S. (2015). Efficacy of Amphotericin-B, Clinicopathologic Variables and Oxidative Stress Markers in three Staffordshire Bull Terrier Dogs with Visceral Leishmaniasis. Veterinary Sciences and Practices, Cilt: 10 Sayı: 1. https://doi.org/10.17094/avbd.44294

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