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Journals / Atatürk Üniversitesi Veteriner Bilimleri Dergisi / 2018 / Cilt: 13 - Sayı: 1

The Effect of Naringenin on Oxidative Stress in Some Tissues (Heart, Lung, Brain, Spleen, Muscle) of Lead-treated Rats

Kurşun Uygulanan Ratların Bazı Dokularında (Kalp, Akciğer, Beyin, Dalak, Kas) Oksidatif Stress Üzerine Naringeninin Etkisi

Mine ERİŞİR
Ahmet ÖZKAYA
Fulya BENZER
Üzeyir DAĞ
Pages
34–41
Publication Date
2022-10-11
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Lead caused a statistically significant decrease in GSH-Px activity of the brain, spleen and muscle tissues, in CAT activity of the heart, lung and muscle tissues, in GSH concentration of the lungs and muscle tissues (P

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Naringenin, a flavonoid increases resistance against oxidative stress.
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Key Findings & Data:Naringenin was administered by orogastric gavage (50 mg/kg, dissolved in corn oil) and lead acetate was given as daily 500 parts per million in drinking water for 4 weeks.
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Conclusion & Impact:Lead caused a statistically significant decrease in GSH-Px activity of the brain, spleen and muscle tissues, in CAT activity of the heart, lung and muscle tissues, in GSH concentration of the lungs and muscle tissues (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Naringenin, a flavonoid increases resistance against oxidative stress. The present study aims to investigate the effect of lead on lipid peroxidasyonu and some antioxidants in heart, lung, brain, spleen, muscle and the effect of naringenin on these parameters. Naringenin was administered by orogastric gavage (50 mg/kg, dissolved in corn oil) and lead acetate was given as daily 500 parts per million in drinking water for 4 weeks. In the rats exposed to lead, MDA levels in the brain, lungs, spleen and muscle tissues significantly increased (P0.05). Lead caused a statistically significant decrease in GSH-Px activity of the brain, spleen and muscle tissues, in CAT activity of the heart, lung and muscle tissues, in GSH concentration of the lungs and muscle tissues (P

Özet

Naringenin oksidatif strese karşı direnci artıran bir flavonoiddir. Bu çalışmada kurşun maruziyeti ile ratların kalp, akciğer, beyin,dalak ve kas dokularında lipid peroksidasyon ve bazı antioksidanların ayrıca bu parametreler üzerine naringeninin etkisininaraştırılması hedeflendi. Naringenin 50 mg/kg dozda mısır yağında çözülerek orogastrik sonda ile kurşun asetat ise günlük 500 ppm olacak sekilde içme suyuna karıştırılarak 4 hafta boyunca verildi. Kurşuna maruz kalan ratların beyin, akciğer, dalak ve kas dokularının MDA düzeylerinde istatistik olarak anlamlı artış (P0.05). Kurşun uygulaması beyin, dalak, kas dokusunda GSH-Px aktivitesinde, kalp, akciğer ve kas dokusunda CAT aktivitesinde, akciğer ve kas dokusunda ise GSH konsantrasyonunda istatistik olarak önemli azalmalara sebep oldu (P

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Cite This Article

ERİŞİR, M., ÖZKAYA, A., BENZER, F., DAĞ, Ü. (2022). The Effect of Naringenin on Oxidative Stress in Some Tissues (Heart, Lung, Brain, Spleen, Muscle) of Lead-treated Rats. Atatürk Üniversitesi Veteriner Bilimleri Dergisi, Cilt: 13 - Sayı: 1, 34–41. https://ajindex.com/articles/455801

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References (11)

  1. Chtourou Y., Fetoui H., Jemai R., Ben Slima A., Makni M., Gdoura R., 2015. Naringenin reduces cholesterol-induced hepatic inflammation in rats by modulating matrix metalloproteinases-2, 9 via inhibition of nuclear factor κB pathway. Eur J Pharmacol, 746, 96-105.
  2. Fernandez MT., Mira ML., Florêncio MH., Jennings KR., 2002. Iron and copper chelation by flavonoids: an electrospray mass spectrometry study. J Inorg Biochem, 92, 105-111. van Acker FA., Schouten O., Haenen GR., van der Vijgh WJ., Bast A., 2000. Flavonoids can replace alpha-tocopherol as an antioxidant. FEBS Lett, 473, 145-148.
  3. Han X., Pan J., Ren D., Cheng Y., Fan P., Lou H., 2008. Naringenin-7-O-glucoside protects against doxorubicin-induced toxicity in H9c2 cardiomyocytes by induction of endogenous antioxidant enzymes. Food Chem Toxicol, 46, 3140-3146.
  4. Chtourou Y., Fetoui H., Gdoura R., 2014. Protective effects of naringenin on iron-overloadinduced cerebral cortex neurotoxicity correlated with oxidative stress. Biol Trace Elem Res, 158, 376-83.
  5. Kannappan S., Palanisamy N., Anuradha CV., 2010. Suppression of hepatic oxidative events and regulation of eNOS expression in the liver by naringenin in fructose administered rats. Eur J Pharmacol, 645, 177-184.
  6. Oyagbemi AA., Omobowale TO., Akinrinde AS., Saba AB., Ogunpolu BS., Daramola O., 2015. Lack of reversal of oxidative damage in renal tissues of lead acetate-treated rats. Environ Toxicol, 30, 1235-1243.
  7. Abdel Moneim AE., Dkhil MA., Al-Quraishy S., 2011. Effects of flaxseed oil on lead acetateinduced neurotoxicity in rats. Biol Trace Elem Res, 144, 904-913.
  8. Christie NT., Costa M., 1984. In vitro assessment of the toxicity of metal compounds: IV. Disposition of metals in cells: Interactions with membranes, glutathione, metallothionein, and DNA. Biol Trace Elem Res, 6, 139-158.
  9. Saxena G., Pathak U., Flora SJ., 2005. Beneficial role of monoesters of meso-2,3- dimercaptosuccinic acid in the mobilization of lead and recovery of tissue oxidative injury in rats. Toxicol, 214, 39-56. Gutteridge JM., 1995. Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin Chem, 41, 1819-1828.
  10. Soleimani E., Goudarzi I., Abrari K., Lashkarbolouki T., 2016. The combined effects of developmental lead and ethanol exposure on hippocampus dependent spatial learning and memory in rats: Role of oxidative stress. Food Chem Toxicol, 96, 263-72.
  11. Cole GM., Teter B., Frautschy SA., 2007. Neuroprotective effects of curcumin. Adv Exp Med Biol, 595, 197-212. Shahande