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Journals / Anadolu Kardiyoloji Dergisi / 2008 / Cilt: 8 - Sayı: 6

Koroner arter baypas cerrahisinde kardiyoplejiye eklenen düşük doz N-asetilsisteinin (NAC) etkileri

The effects of low dose N-acetylcysteine (NAC) as an adjunct to cardioplegia in coronary artery bypass surgery

İhsan HALİFEOĞLU
Mustafa Kemal BAYAR
Oktay BURMA
Ali RAHMAN
Hakan KÖKSAL
Pages
437–443
Publication Date
2022-10-10
DOI
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The MDA levels were significantly lower in NAC group than in control group during reperfusion period (0.75 nmol/l vs 0.88 nmol/l, p

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Objective & Hypothesis:Objective: We aimed to evaluate the efficacy of low dose N-acetylcysteine (NAC) against myocardial ischemia-reperfusion damage in coronary artery bypass surgery accompanied by cardiopulmonary bypass (CPB).Methods: Thirty patients operated due to triple coronary artery disease were enrolled into this prospective randomized study (control group -n=15 and NAC group - n=15).
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Key Findings & Data:N-acetylcysteine was added to induction cardioplegia solution in dose of 4 mmol/l and in dose of 2 mmol/l tomaintenance cardioplegia solution in the NAC group.
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Conclusion & Impact:The MDA levels were significantly lower in NAC group than in control group during reperfusion period (0.75 nmol/l vs 0.88 nmol/l, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: We aimed to evaluate the efficacy of low dose N-acetylcysteine (NAC) against myocardial ischemia-reperfusion damage in coronary artery bypass surgery accompanied by cardiopulmonary bypass (CPB).Methods: Thirty patients operated due to triple coronary artery disease were enrolled into this prospective randomized study (control group -n=15 and NAC group - n=15). N-acetylcysteine was added to induction cardioplegia solution in dose of 4 mmol/l and in dose of 2 mmol/l tomaintenance cardioplegia solution in the NAC group. Hemodynamic measurements were performed before and after anesthesia with different intervals. Creatine kinase-MB (CK-MB) levels were analyzed during 24 hours postoperatively. Blood samples were obtained from coronary sinus before CPB (T1), just before the cross-clamp removed (T2) and 30 minutes later (T3). Malondialdehyde (MDA), glutathione peroxidase (GSH-Px), nitric oxide (NO) levels and neutrophil percentage were determined. Statistical analysis was performed using student’s t test, Chi-square and two-way ANOVA tests. Results: There were no significant differences between the two groups with regard to the hemodynamic parameters, and CK-MB levels. The MDA levels were significantly lower in NAC group than in control group during reperfusion period (0.75 nmol/l vs 0.88 nmol/l, p

Özet

Amaç: Kardiyopulmoner baypas eşliğinde yapılan koroner arter baypas cerrahisinde miyokard iskemi-reperfüzyon hasarına karşı düşük doz N-asetilsisteinin (NAC) etkisini değerlendirmeyi amaçladık. Yöntemler: Üç damar hastalığına bağlı opere edilen 30 hasta bu ileriye dönük randomize çalışmaya alındı (kontrol grubu - n=15 ve NAC grubu - n=15). Çalışma grubunda, indüksiyon kardiyopleji solüsyonuna - 4 mmol/l, idame kardiyopleji solüsyonuna her birine 2 mmol/l NAC eklendi. Hemodinamik ölçümler anestezi öncesi ve sonrasında farklı sürelerde yapıldı. Kreatin kinaz- MB (CK-MB) seviyeleri postoperatif 24. saate kadar ölçüldü. Kan örnekleri kardiyopulmoner baypastan önce (T1), kros klemp kaldırılmadan hemen önce (T2) ve 30 dakika sonra (T3) koroner sinüsten alındı. Malondialdehid (MDA), glütatyon peroksidaz (GSH-Px), nitrik oksit (NO) seviyeleri ve nötrofil yüzdesi ölçüldü. İstatistiksel analiz için eşleştirilmemiş t, Ki-kare ve iki-yönlü ANOVA testleri kullanıldı. Bulgular: İki grup arasında hemodinamik ölçümlerde anlamlı farklılık yoktu. Gruplar arasında CK-MB seviyelerinde de farklılık bulunmadı. Reperfüzyon döneminde ise MDA seviyeleri, çalışma grubunda, kontrol grubuna göre anlamlı olarak düşük bulundu (0.75 nmol/l’e karşı 0.88 nmol/l, p

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Cite This Article

HALİFEOĞLU, İ., BAYAR, M. K., BURMA, O., RAHMAN, A., KÖKSAL, H. (2022). Koroner arter baypas cerrahisinde kardiyoplejiye eklenen düşük doz N-asetilsisteinin (NAC) etkileri. Anadolu Kardiyoloji Dergisi, Cilt: 8 - Sayı: 6, 437–443. https://ajindex.com/articles/437011

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