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Journals / Fırat Tıp Dergisi / 2004 / Cilt: 9 Sayı: 4

Analysis of Serum Leptin Levels in Patıents With Prostate Cancer, Benign Prostatic Hyperplasia and Healthy (Young and Aged) Controls

Serum Leptin Düzeylerinin Prostat Kanserli ve Benign Prostat Hiperplazili Hastalarda ve Sağlıklı Kontrollerde (Genç ve Yaşlı) Saptanması

Halit Canatan
İhsan Halifeoğlu
M.ferit Gürsu
Arslan Ardıçoğlu
Dilnur Dinçoğlu
İbrahim Bakan
Pages
112–115
Publication Date
2004-08-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

When serum leptin and leptin/BMI were analyzed, there was a statistically significant increase in Group B compared to Group C (p

📌 3 Key Takeaways

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Objective & Hypothesis:Leptin which is the product of Ob gene derived from adipocytes is a hormone with roles in energy balance, appetite and it has close ties with endocrine as well as metabolic systems.
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Key Findings & Data:In the present study we investigated whether leptin can be used as a tumor marker for diagnosis and prognosis of prostatic diseases. 23 healthy young volunteers (Group A), 43 healthy aged volunteers (Grup B), 23 patients with PCa (Group C), 23 patients with BPH were recruited into the study.
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Conclusion & Impact:When serum leptin and leptin/BMI were analyzed, there was a statistically significant increase in Group B compared to Group C (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Leptin which is the product of Ob gene derived from adipocytes is a hormone with roles in energy balance, appetite and it has close ties with endocrine as well as metabolic systems. Relationship between leptin and prostate cancer and benign Prostatic hyperplasia (BPH) is currently under investigation. In the present study we investigated whether leptin can be used as a tumor marker for diagnosis and prognosis of prostatic diseases. 23 healthy young volunteers (Group A), 43 healthy aged volunteers (Grup B), 23 patients with PCa (Group C), 23 patients with BPH were recruited into the study. Serum leptin, f-PSA, t-PSA, total cholesterol (Chol), triglyceride , HDL-chol, VLDL-chol, VLDL-chol levels were determined in all groups. When serum leptin and leptin/BMI were analyzed, there was a statistically significant increase in Group B compared to Group C (p

Özet

Ob gen ürünü olan leptin, enerji dengesi, iştah üzerine önemli rolü olan, endokrin ve metabolik sistemlerle sıkı ilişki içerisinde adiposit kaynaklı bir hormondur. Prostat kanseri ve BPH ile leptin arasındaki ilişki halen araştırılmaktadır. Bu çalışmada leptinin prostat hastalıklarının tanı ve tedavisinin izlenmesinde kullanılabilecek ve tümör belirleyici özelliklere sahip bir molekül olup olmadığını araştırdık. Çalışmaya 23 sağlıklı genç kontrol (Grup A), 21 sağlıklı yaşlı kontrol (Grup B), 23 Prostat Kanser'li hasta 23 BPH'lı hasta (Grup D) dahil edildi. Tüm gruplarda Serum leptin, serbest PSA (f- PSA), total PSA (t-PSA), kolestrol, trigliserid, HDL-kolestrol, LDL-kolestrol, VLDL-kolestrol düzeyleri ölçüldü. Serum leptin ve leptin/VKİ düzeylerinin bütün gruplarda incelenmesinde, Grup B'de Grup C'ye oranla anlamlı derecede yüksek olduğu ortaya konuldu (p

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Cite This Article

Canatan, H., Halifeoğlu, İ., Gürsu, M., Ardıçoğlu, A., Dinçoğlu, D., Bakan, İ. (2004). Analysis of Serum Leptin Levels in Patıents With Prostate Cancer, Benign Prostatic Hyperplasia and Healthy (Young and Aged) Controls. Fırat Tıp Dergisi, Cilt: 9 Sayı: 4, 112–115. https://ajindex.com/articles/988304

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