SavedAdd your journal

Journals / Adnan Menderes Üniversitesi Tıp Fakültesi Dergisi / 2000 / Cilt: 1 - Sayı: 3

Lipid peroxidation in patients with multipl myeloma

Multipl myelomalı hastalarda lipid peroksidasyonu (Ön çalışma)

Yaşar ENLİ
Zahit BOLAMAN
Mehmet H. KÖSEOĞLU
Süleyman DEMİR
Diler ASLAN
Gürhan KADIKÖYLÜ
Pages
13–15
Publication Date
2022-10-10
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Plasma MDA levels were found to be higher in multiple myeloma in comparison to control group (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:We investigated the malondialdehyde (MDA) levels as a parameter of lipid peroxidation in patients with multiple myeloma as a preliminary report.
📊
Key Findings & Data:Fasting venous blood samples were drawn in 12 patients with multiple myeloma and 15 healthy persons.
💡
Conclusion & Impact:Plasma MDA levels were found to be higher in multiple myeloma in comparison to control group (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

We investigated the malondialdehyde (MDA) levels as a parameter of lipid peroxidation in patients with multiple myeloma as a preliminary report. Fasting venous blood samples were drawn in 12 patients with multiple myeloma and 15 healthy persons. Serum was separated and frozen at -20 C°. All samples were thawed at room temperature and MDA levels were measured by the method in which MDA reacted with thiobarbituric acid and produced a colored complex. This colored complex was read by optic scale at 532 wavelength . MDAlevels were 1.51±0.16 nmol/ml in patients with multiple myeloma and 0.97±0.11 nmol/ml in the control group (P0.05). Plasma MDA levels were found to be higher in multiple myeloma in comparison to control group (p

Özet

Multipl myelomlu hastalarda lipid peroksidasyonunun aktivitesini belirlemek için ön çalışma olarak serum malondialdehit (MDA) düzeyinin ölçülmesi esasına dayanmaktadır. On iki multipl myelomlu hasta ve onbeş sağlıklı kontrol gurubunda açlık venöz kan örneklerinden elde edilen serum örnekleri analiz edilene dek -20 C° de donduruldu.Tümörnekler oda sıcaklığında ısıtıldı. MDA'nın asidik ortamda tiyobarbutirik asitle oluşturduğu renk şiddeti 532 nm dalga boyunda spektrofotometrede okunması ile yapıldı. Multipl myelomlu hastalarda serumMDAdüzeyleri ortalama 1.51±0.16 nmol/ml, kontrol gurubunda ise 0.97±0.11nmol/ml (p:0.0321) olarak bulundu. MDA düzeyi ile yaş, cins, paraprotein ve hafif zincir tipi, hemoglobin düzeyi arasında ilişki yoktu (p>0.05). Serum MDAdüzeyi multipl myelomlu hastalarda kontrol gurubuna göre yüksek saptandı (p

🔖

Cite This Article

ENLİ, Y., BOLAMAN, Z., KÖSEOĞLU, M. H., DEMİR, S., ASLAN, D., KADIKÖYLÜ, G. (2022). Lipid peroxidation in patients with multipl myeloma. Adnan Menderes Üniversitesi Tıp Fakültesi Dergisi, Cilt: 1 - Sayı: 3, 13–15. https://ajindex.com/articles/429161

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (17)

  1. Barlogie B, Epstein J, Selvanayagam P, Alexanian R.Plasma cell myeloma-new biological insight and advances in therapy. Blood 1989
  2. Hallek M, Bergsagel PL, Anderson KC. Multiple myeloma:increasing evidence for a multistep transformation process. Blood 1998
  3. 21 3.Halliwell B, Gutteridge JMC. Free radicals in biology and medicine. Oxford Medicine Press, 1999
  4. Allen RG, Venkatraj VS. Oxidants and antioxidants in development and differentiation. J Nutr 1992
  5. Tamer L, Polat G, Eskandari G, Ercan B, Atik U.Serbest Radikaller. Mersin Üniversitesi Tıp Fakültesi Dergisi 2000
  6. Ray C, Batra S, Shukla NK, Doo S, Raina V, Ashok S,Husain SA. Lipid peroxidation, free radical production and antioxidant status in breast cancer. Breast Cancer ResTreat 2000 59:163-70. 7.Cheeseman KH, Slater TF. An introduction to free radical biochemistry in vivo. British Medical Bulletin 1993
  7. Janero DR. Malondialdehyde and thiobarbituric acidreactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radic Biol Med 1990
  8. Devi GS, Prasad MH, Saraswathi I, Raghu D, Rao DN,Reddy PP. Free radicals antioxidant enzymes and lipid peroxidation in different types of leukemias. Cli Chim Acta 2000
  9. Ghalaut VS, Ghalaut PS, Singhs S. Lipid perxidation in leukemia. J Asssoc Physician India 1999
  10. Güven M, Özturk B, Sayal A Özet A. Lipid peroxidation and antioxidant system nthe blood of patients with Hodgkin's disease. Clin Biochem 2000
  11. Sabitha KE, Shymaladevi CS. Oxidant and antioxidant activity changes in patients with oral cancer and treated with radiotherapy. Oral Oncol 1999
  12. Sadani GR, Nadkarni GD. Role of tissue antioxidant defence in thyroid cancers. Cancer Lett 1996
  13. Iwagaki H, Hamazaki K, Matsubara N, Hiramatsu M,Orita K, Mori A. Lipid peroxidation in hepatocelluler carcinoma. Acta Med Okayama 1995
  14. Zima T, Spicka I, Stipek S, Crkovska J, Platenik J,Merta M, Tesar V. Antioxidant enzymes and lipid peroxidation in patients with multiple myeloma. Neoplasma 1996
  15. Ohkawa H, Ohishi N,Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979
  16. Cheeseman KH. Mechanisms and effects of lipid peroxidation. Mol AspectMed1993
  17. Li B, Gutierrez PL, Amstad P, Blough NV. Hydroxyl radical production by mouse epidermal cell line in the presence of