AI Summary & Key Takeaways
AI InsightResults: In the diltiazem group, cardiac output and cardiac index was found to be lower in postoperative 1st and 6th hours (p
📌 3 Key Takeaways
Abstract
Objective: The aim of this prospective study was to demonstrate the effect of diltiazem, a calcium channel blocker, as an additive to cardioplegic solution in myocardial protection. Methods: Thirty patients who underwent coronary artery bypass grafting on an elective basis were divided into two groups: control group and diltiazem group (n=15, each). Diltiazem was added to the blood cardioplegic solution in the diltiazem group. Mean age was 56.8+10.11 years in the control group and 60.20+10.44 in the diltiazem group. There was no difference in the extent of coronary artery disease, cross-clamp time, cardiopulmonary bypass (CPB) time between the two groups. Cardioplegic solution was delivered antegradely. Hemodynamics and blood enzyme levels were measured before and following CPB. Results: In the diltiazem group, cardiac output and cardiac index was found to be lower in postoperative 1st and 6th hours (p
Özet
Amaç: Bu çalışmanın amacı Ca++ antagonisti olan diltiazemin kardiyoplejik solüsyona eklenmesinin myokard korunmasındaki etkilerinin araştırılmasıdır. Yöntem: Aortakoroner bypass operasyonu uygulanan 30 elektif hasta, kontrol ve çalışma grubu olarak 15'er kişilik 2 gruba ayrıldı. Kontrol grubunda yaş ortalaması (56.8±10.11), çalışma grubunda ise (60.20±10.44) idi. Her iki grup arasında koroner lezyon, X- klemp, Kardiyopulmoner bypass (CPB) süreleri açısından fark saptanmadı. Kardiyopleji iki gruba da antegrad yoldan verildi. Hemodinamik ölçümler ve enzim tayinleri CPB öncesi ve sonrasında ayrı ayrı değerlendirildi. Bulgular: Kardiyoplejik solüsyona eklenen diltiazem ile hemodinamik parametrelerden CO ve CI deki 1. ve 6. saatlerdeki düşük bulundu(p