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Journals / Adnan Menderes Üniversitesi Tıp Fakültesi Dergisi / 2004 / Cilt: 5 - Sayı: 1

Light microscopic analysis of the effects of Gd-DTPA dimeglumine and iopromide on rabbit hyaline cartilage and synovial membrane

Gd-DTPA dimeglumine ve iopromid'in tavşan kıkırdak ve sinoviyal membrane üzerindeki etkilerinin ışık mikroskop düzeyinde değerlendirilmesi

Hakan ÖMEROĞLU
Cengiz BAYÇU
Ulukan İNAN
Sinan SEBER
Nusret KÖSE
Pages
17–21
Publication Date
2022-10-10
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: We were not able to demonstrate that contrast agents have any significant effect on hyaline cartilage and synovial membrane (p>0.05).

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The aim of this study is to assess the effects of contrast agents on hyaline cartilage and synovial membrane in a rabbit model.
📊
Key Findings & Data:Material and Method: Light microscopic analysis of the effects of intraarticular lopromide and Gd-DTPA on synovial membrane and hyaline cartilage at 1 st hour, 1 st day, 1 st week and 2nd week was performed.
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Conclusion & Impact:Conclusion: We were not able to demonstrate that contrast agents have any significant effect on hyaline cartilage and synovial membrane (p>0.05).
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study is to assess the effects of contrast agents on hyaline cartilage and synovial membrane in a rabbit model. Material and Method: Light microscopic analysis of the effects of intraarticular lopromide and Gd-DTPA on synovial membrane and hyaline cartilage at 1 st hour, 1 st day, 1 st week and 2nd week was performed. NaCl%0.9 was used as control. Results: Hyperemia, hemorhage and increase in the vacuolised cell number in the superficial stroma were observed in the synovial membrane. Proliferation, hypertrophy, dense glycogen storage, pycnosis and decrease in glycosaminoglycan (GAG) staining were observed in the hyaline cartilage. These effects lessened in two weeks. Conclusion: We were not able to demonstrate that contrast agents have any significant effect on hyaline cartilage and synovial membrane (p>0.05).

Özet

Amaç: Bu çalışmanın amacı kontrastlı maddelerin eklem kıkırdağı ve sinoviyal membran üzerine olan etkilerim tavşan modelinde araştırmaktır. Yöntem: Çalışmada 60 tavşan dizi kullanıldı. Kontrastlı ajan olarak İopromid ve Gd-DTPA diz eklemlerine intraartiküler uygulanarak l. saat, l .gün, l .hafta ve 2.hafta sonra sinoviyal membran ve hiyalin kıkırdak üzerine olan histolojik etkileri ışık mikroskobisi yardımı ile incelendi. Kontrol grubu olarak serum fizyolojik kullanıldı. Bulgular: İopromid ve Gd-DTPA uygulanmasından sonra sinoviyal membranda hiperemi, hemoraji ve yüzeyel stromada vakuollü hücre artışına rastlandı. Hiyalin kıkırdakta ise proliferasyon, hipertrofi ve yoğun glikojen birikimi, piknoz ve Glikoz Amino Glikan boyanma azlığına neden olduğu görüldü. Bu etkilerin 2. hafta sonunda azalarak devam ettiği saptandı. Sonuç: Çalışmamızda kullanılan maddelerin uygulama süreleri boyunca eklem kıkırdağına ve sinoviyal membran üzerine olan etkilerinin istatistiksel olarak anlamlı olduğu gösterilememiştir (p>0.05).

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Cite This Article

ÖMEROĞLU, H., BAYÇU, C., İNAN, U., SEBER, S., KÖSE, N. (2022). Light microscopic analysis of the effects of Gd-DTPA dimeglumine and iopromide on rabbit hyaline cartilage and synovial membrane. Adnan Menderes Üniversitesi Tıp Fakültesi Dergisi, Cilt: 5 - Sayı: 1, 17–21. https://ajindex.com/articles/429082

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