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Journals / Turkish Journal of Pharmaceutical Sciences / 2008 / Cilt: 5 - Sayı: 3

5-klora-2(3H)-benzoksazolinon-3-asetil-2-(p-sübstitüe benzal) hidrazon ve 5-kloro-2(3H)-benzoksazolinon-3-asetil-2-(p-sübstitüe asetofenon) hidrazon türevlerinin mikrodalga sentezi ve antimikrobiyal aktivitelerinin değerlendirilmesi

Microwave synthesis and antimicrobial evaluation of 5-chloro-2(3H)-benzoxazolinone-3-acetyl-2-(p-substituted benzal) hydrazone and 5-chloro-2(3H)-benzoxazolinone-3-acetyl-2-(p-substituted acetophenone) hydrazone derivatives

TİJEN ÖNKOL
Mehtap GÖKÇE
Ali Ulvi Tosun
Serpil POLAT
Mehmet M. SERİN
SEDA TEZCAN ÜLGER
Pages
155–166
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The minimum inhibition concentration (MIC) values of the compounds were determined by the Microdilution method using two Gram positive bacteria (Staphylococcus aureus, Bacillus subtilis), two Gram negative bacteria (Pseudomonas aeruginosa, Escherichia coli) and two yeast like fungi (Candida albicans, Candida parapsilosis).

📌 3 Key Takeaways

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Objective & Hypothesis:In the present study seven 5-chloro-2(3H)-benzoxazolinone-3-acetyl-2-(p-substituted benzal-hydrazone derivatives and four 5-chloro-2(3H)-benzoxazolinone-3-acetyl-2-(p-substituted acetophe-none)hydrazone derivatives were synthesized.
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Key Findings & Data:Among them, the analytical data of five original compounds were given.
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Conclusion & Impact:The minimum inhibition concentration (MIC) values of the compounds were determined by the Microdilution method using two Gram positive bacteria (Staphylococcus aureus, Bacillus subtilis), two Gram negative bacteria (Pseudomonas aeruginosa, Escherichia coli) and two yeast like fungi (Candida albicans, Candida parapsilosis).
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Değerlendirme çalışmaları · Mikrodalgalar · Benzaldehit

Abstract

In the present study seven 5-chloro-2(3H)-benzoxazolinone-3-acetyl-2-(p-substituted benzal-hydrazone derivatives and four 5-chloro-2(3H)-benzoxazolinone-3-acetyl-2-(p-substituted acetophe-none)hydrazone derivatives were synthesized. Among them, the analytical data of five original compounds were given. In this study, the microwave synthesis method and antimicrobial evaluation of all the compounds were also reported for the first time. The minimum inhibition concentration (MIC) values of the compounds were determined by the Microdilution method using two Gram positive bacteria (Staphylococcus aureus, Bacillus subtilis), two Gram negative bacteria (Pseudomonas aeruginosa, Escherichia coli) and two yeast like fungi (Candida albicans, Candida parapsilosis).

Özet

Sunulan bu çalısmada yedi 5-kloro-2(3H)-benzoksazolinon-3-asetil-2-(p-sübstitüe benzal)hidrazon ve dört 5-kloro-2(3H)-benzoksazolinon-3-asetil-2-(p-sübstiüe asetofenon)hidrazon türevinin sentezi yapımitır. Bunların arasında, beş orijinal bileşiğin analiz değerleri verilmiştir.. Bu çalısmada aynı zamanda tüm bileşiklerin mikrodalga sentezi ve antimikrobiyal degerlendirilmesi ilk defa rapor edilmiştir. Bileşiklerin minimum inhibitör konsantrasyonlan (MlK) iki Gram pozitif bakteri (Staphylococcus aureus, Bacillus subtilis), iki Gram negatif bakteri (Pseudomonas aeruginosa, Escherichia coli) ve iki maya benzeri fungus üzerinde (Candida albicans, Candida parapsilosis) üzerinde değerlendirilmiştir.

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Cite This Article

ÖNKOL, T., GÖKÇE, M., Tosun, A. U., POLAT, S., SERİN, M. M., ÜLGER, S. T. (2008). 5-klora-2(3H)-benzoksazolinon-3-asetil-2-(p-sübstitüe benzal) hidrazon ve 5-kloro-2(3H)-benzoksazolinon-3-asetil-2-(p-sübstitüe asetofenon) hidrazon türevlerinin mikrodalga sentezi ve antimikrobiyal aktivitelerinin değerlendirilmesi. Turkish Journal of Pharmaceutical Sciences, Cilt: 5 - Sayı: 3, 155–166. https://ajindex.com/articles/403843

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