All compounds were screened for their antiviral and antimicrobial activities aganist various virus, bacteria and fungi strains.
📌 3 Key Takeaways
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Objective & Hypothesis:In this study, new eleven hydrazone derivatives of (5-chloro-2(3H)-benzothiazolinone-3-yl) aceto/propanohydrazide have been synthesized.
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Key Findings & Data:Structures of the synthesized compounds have been elucidated by IR and 'H-NMR spectral data and their elemental analyses.
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Conclusion & Impact:All compounds were screened for their antiviral and antimicrobial activities aganist various virus, bacteria and fungi strains.
In this study, new eleven hydrazone derivatives of (5-chloro-2(3H)-benzothiazolinone-3-yl) aceto/propanohydrazide have been synthesized. Structures of the synthesized compounds have been elucidated by IR and 'H-NMR spectral data and their elemental analyses. All compounds were screened for their antiviral and antimicrobial activities aganist various virus, bacteria and fungi strains.
Özet
Bu çalışmada (5-kloro-2(3H)-benzotiyazolinon-3-il)aseto/propanohidrazitin onbir yeni hidrazon türevi sentezlenmiştir. Sentezlenen bileşiklerin yapıları IR ve ]H-NMR spektral verileri ve elementel analiz sonuçları ile açıklanmıştır. Sentezlenen tüm bileşiklerin antiviral ve antimikrobiyal aktiviteleri çeşitli virus, bakteri vefunguslara karşı değerlendirilmiştir.
Özçelik, B., Aslan, M., Orhan, I., Karaoglu, T., Antibacterial, antifungal, and antiviral activities of the lipophylic extracts of Pistacia vera, Microbiol. Res., 160,159-164, 2005. 2.Özçelik, B., Orhan, I., Toker, G., Antiviral and antimicrobial assessment of some selected flavonoids, Z.Naturforsch., 61c, 632-638, 2006. 3.Özçelik, B., Gürbüz, I., Karaoglu, T., Yesilada, E., Antiviral and antimicrobial activities of three sesquiterpene lactones from Centaurea solstitialis L. ssp. solstitialis, Microbiol. Res., 2009 (in press). 4.Gökçe, M., Özçelik, B., Bakir, G., Karaoglu, T., Berçin, E., Noyanalpan, N., Antiviral and antimicrobial activities of new nitrobutane derivatives, Arzneim. Forsch. Drug Res., 54, 891-897, 2004. 5.Esquenazi, D., Wigg, M. D., Miranda, M.F.S., Rodrigues, H. M., Tostes, B. F., Rozental, S., Silva, J. R., Alviano, C. S., Antimicrobial and antiviral activities of polyphenolics from Cocos nucifera Linn. (Palmae) husk fiber extract, Res. Microbiol., 153, 647-652, 2002. 6.Abad, M. J., Guerra, J. A., Bermejo, P., Irurzun, A., Carrasco, L., Search for antiviral activity in higher plant extracts, Phytother Res., 14, 604-607, 2000. 7.Gold, H. S., Moellering, R. C, Antimicrobial-drug resistance. N. Engl. J. Med., 335, 1445_1453? 1996. 8.Bossche, H. V., Marichal, P., Odds, F. C, Molecular mechanisms of drug resistance in fungi, Trends Microbiol, 10, 393-400,1994. 9.Cohen, M. L., Epidemiology of drug resistance: implications for a post-antimicrobial era, Science, 257, 1050-1055,1992. 10.Gökçe, M., Çakır, B., Özçelik,B., Abbasoğlu, U., Şahin, M. F., Synthesis and antimicrobial activity of some 4-alkyl and aryl substituted [(2-oxobenzothiazolin-3-yl)acetyl]-3-semicarbazides and thiosemicarbazides, J. Fac. Pharm. Gazi, 17, 61-70, 2000. 11.Şimşek, R., Atlas, Y., Safak, C, Abbasoglu, U., Ozcelik, B., Synthesis and antimicrobial activity of some 2-(2-oxobenzothiazol-3-yl)-l-arylethanone derivatives, Farmaco, 50, 893-894,1995. 12.Çakır, B., Yıldırım, E., Ercanlı, T., Erol, K., Şahin, M. F., Synthesis and anticonvulsant activity of some (2/4-substituted)benzaldehyde (2-oxobenzothiazolin-3-yl)acetohydrazones, Farmaco, 54, 842-845,1999. 13.Uçar, H., Van Derpoorten, K., Cacciaguerra, S., Spampinato, S., Stables, J. P., Depovere, P.,Isa, Masereel, B., Delarge, J., Poupaert, J.H., Synthesis and Anticonvulsant Activity of 2(3H)-Benzoxazolone and 2(3H)-Benzothiazolone Derivatives, J.Med. Chem., 41, 1138-1145,1998. 14.Önkol, T., Doğruer, D. S., Şahin, M. F.,