We also determined for their gastric ulceration potential in the tested animals. l-[2-(6-(2-fluorobenzoyl)-2-benzothiazolinon-3-yl)acetyl]-4-(4-fluoro-phenyl)piperazine (Compound 7i) exhibited the highest analgesic and, anti-inflammatory.
📌 3 Key Takeaways
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Objective & Hypothesis:In order to develop potent analgesic and anti-inflammatory compounds, we synthesized (6-acyl-2-benzothiazolinon-3-yl)acetamide /propanamide derivatives and screened their in vivo analgesic and anti-inflammatory activities at a single dose of 100 mg/kg in mice by p-benzoquinone-induced writhing test and Carrageenan induced hind paw edema model, respectively.
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Key Findings & Data:In order to develop potent analgesic and anti-inflammatory compounds, we synthesized (6-acyl-2-benzothiazolinon-3-yl)acetamide /propanamide derivatives and screened their in vivo analgesic and anti-inflammatory activities at a single dose of 100 mg/kg in mice by p-benzoquinone-induced writhing test and Carrageenan induced hind paw edema model, respectively.
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Conclusion & Impact:We also determined for their gastric ulceration potential in the tested animals. l-[2-(6-(2-fluorobenzoyl)-2-benzothiazolinon-3-yl)acetyl]-4-(4-fluoro-phenyl)piperazine (Compound 7i) exhibited the highest analgesic and, anti-inflammatory.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Anti-enflamatuvar ajanlar · Benzotiyazoller · Teknoloji
Abstract
In order to develop potent analgesic and anti-inflammatory compounds, we synthesized (6-acyl-2-benzothiazolinon-3-yl)acetamide /propanamide derivatives and screened their in vivo analgesic and anti-inflammatory activities at a single dose of 100 mg/kg in mice by p-benzoquinone-induced writhing test and Carrageenan induced hind paw edema model, respectively. We also determined for their gastric ulceration potential in the tested animals. l-[2-(6-(2-fluorobenzoyl)-2-benzothiazolinon-3-yl)acetyl]-4-(4-fluoro-phenyl)piperazine (Compound 7i) exhibited the highest analgesic and, anti-inflammatory.
Özet
Etkili analjezik ve antienflamatuvar bileşikler geliştirmek amacıyla (6-açil-2-benzotiyazolinon-3-il)asetamit /propanamit türevleri sentez edilmiş ve bunların analjezik ve antienflamatuvar etkileri 100 mg/kg dozda fareler üzerinde test edilmiştir.Test edilen hayvanlarda gastrik lezyon etkileri değerlendirilmiştir. Bu çalışmada l-[2-(6-(2-florobenzoil)-2-benzotiyazolinon-3-il)asetil]-4-(4-florofenil)piperazine (Bileşik 7i) bileşiğinin en yüksek analjezik ve antienflamatuvar etkiye sahip olduğu bulunmuştur.
ÖNKOL, T., ÜNLÜ, S., KÜPELİ, E., YEŞİLADA, E., ŞAHİN, M. F. (2009). Analjezik ve antienflamatuvar ajan olarak (6-Acyl-2-(3H)-benzotiyazolinon-3-il) asetamit/ / propanamit türevlerinin sentezleri. Turkish Journal of Pharmaceutical Sciences, Cilt: 6 - Sayı: 2, 93–106. https://ajindex.com/articles/404057
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