Diabetik retinopathy and oxidative stress

Key Findings & Data:Materials and Methods: Twentyfive patients with proliferative diabetic retinopathy (PDR group), 25 patients with nonproliferative diabetic retinopathy (NPDR group) and 25 nondiabetic healthy subjects (control group) were included in the study.

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Conclusion & Impact:Conclusion: Free radical generation and antioxidant defense imbalance may play a role in the progression of diabetic retinopathy.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Oksidatif stres · Diabetik retinopati · Lipid peroksidasyonu

Abstract

Purpose: To evaluate efficiency of oxidative stress in the progression of diabetic retinopathy. Materials and Methods: Twentyfive patients with proliferative diabetic retinopathy (PDR group), 25 patients with nonproliferative diabetic retinopathy (NPDR group) and 25 nondiabetic healthy subjects (control group) were included in the study. Fasting venous blood samples were collected from all subjects. Serum samples were analyzed for triglycerid, total cholesterol, HDL, LDL and VLDL cholesterol, lipid peroxides (thiobarbituric acid substances=TBARS), erythrocyte glutathione peroxidase and catalase activities and HbA1C. However Total antioxidant status was also studied in patients with PDR and NPDR. Results: There was no statistically difference significant between 3 groups for total cholesterol, LDL and HDL cholesterol levels (p>0,05). Serum VLDL cholesterol and triglycerid levels were elevated in PDR group compared with control group (p=0,001). Serum TBARS level were higher in PDR and NPDR groups than control group (p<0,05). There was no correlation between TBARS and lipid levels in all groups (p>0,05). Total antioxidant status levels were higher in PDR group than NPDR group (p<0,05). HbA1C levels were elevated in diabetic patients compared with control subjects (p<0,001). Conclusion: Free radical generation and antioxidant defense imbalance may play a role in the progression of diabetic retinopathy.

Özet

Amaç: Diabetik retinopati ilerlemesinde oksidatif stresin etkisini incelemek. Gereç ve Yöntem: Çalışmamıza 25 proliferatif diabetik retinopatili hasta (PDR grubu), 25 nonproliferatif diabetik retinopatili hasta (NPDR grubu) ve 25 diabetik olmayan sağlıklı birey (kontrol grubu) olmak üzere toplam 75 kişi dahil edildi. Tüm bireylerden ven kan örnekleri alındı. Alınan kan örneklerinde trigliserit, total kolesterol, HDL, LDL ve VLDL kolesterolleri, lipid peroksitleri (tiyobarbitürik asit türevleri= TBARS) eritrosit glutatyon peroksidaz ve katalaz aktiviteleri ve HbA1C çalışıldı. Ayrıca PDR grubu ve NPDR grubu hastalarında total antioksidan status çalışıldı. Bulgular: Serum total kolesterol, LDL ve HDL kolesterol seviyelerinde her 3 grup arasındaki fark anlamlı değildi (p>0,05). Serum VLDL kolesterol ve trigliserit seviyeleri PDR grubunda kontrol grubundan yüksekti (p=0,001). Serum TBARS seviyeleri PDR ve NPDR gruplarında kontrol grubundan yüksekti (p 0,05). Total antioksidan durum düzeyleri PDR grubunda NPDR grubuna göre yüksekti. HbA1C düzeyleri PDR ve NPDR gruplarında kontrol grubundan yüksekti (p<0,001). Sonuç: Diabetik hastalarda serbest radikal oluşumu ve antioksidan savunması arasında oluşan dengesizliğin diabetik retinopatinin ilerlemesinde rol oynayabilir.

Keywords

Oksidatif stres Diabetik retinopati Lipid peroksidasyonu Oxidative Stress Diabetic Retinopathy Lipid Peroxidation

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Cite This Article

UÇGUN, N. İ., YARIŞAN, A., DÜZGÜNÇINAR, Ö., GÜRSEL, E. (2005). Diabetik retinopathy and oxidative stress. Retina-Vitreus, Cilt: 13 - Sayı: 4, 299–302. https://ajindex.com/articles/305288

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