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Journals / Glokom Katarakt / 2014 / Cilt: 9 - Sayı: 1

Humor aqueous tumor necrosis factor-α and nitric oxide levels in pseudoexfoliation syndrome

Psödoeksfolyasyon sendromunda humor aköz tümör nekroz faktör-α ve nitrik oksit düzeyleri

Zuhal YILDIRIM
Nil İrem UÇGUN
Özlem Evren KEMER
Şirin ŞEREFLİ
Pages
33–36
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

TNF-α and nitrite/nitra- tate levels were similar in our study groups.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Purpose: Our purpose in this study was to investigate the role of tumor necrosis factor-α (TNF-α) and nitrite-nitrate in the development of pseudoexfoliation (PEX) syndrome.
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Key Findings & Data:Materials and Methods: A total 30 eyes consisting of 17 eyes without pseudoexfoliation (PEX) syndrome (the control group) and 13 eyes with PEX (the PEX group), that underwent cataract surgery due to senile cataract were included in the study and humor aqueous samples were taken from the anterior chamber during surgery.
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Conclusion & Impact:TNF-α and nitrite/nitra- tate levels were similar in our study groups.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: Our purpose in this study was to investigate the role of tumor necrosis factor-α (TNF-α) and nitrite-nitrate in the development of pseudoexfoliation (PEX) syndrome. Materials and Methods: A total 30 eyes consisting of 17 eyes without pseudoexfoliation (PEX) syndrome (the control group) and 13 eyes with PEX (the PEX group), that underwent cataract surgery due to senile cataract were included in the study and humor aqueous samples were taken from the anterior chamber during surgery. TNF-α and nitrite/nitrate levels were determined in the humor aqueous samples. Results: The average age of the patients was 63.4±4 years in the control group, and 61.3±2 years in the PEX group (p>0.05). The ratio of females to males was 8/9 in the control group and 7/6 in the PEX group (p>0.05). When the PEX group compared with the control group, no significant difference was found between the humor aqueous TNF-α and nitrite/nitrate levels (p>0.05). Conclusion: TNF-α and nitrite/nitrate increase in some ocular pathologies with oxidative stress. TNF-α and nitrite/nitra- tate levels were similar in our study groups.

Özet

Amaç: Bu çalışmada, psödoeksfolyasyon (PEX) sendromu etiyolojisinde tümör nekroz faktör-α (TNF-α) ve nitrit/nitrat’ın etkisinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Senil katarakt nedeniyle katarakt cerrahisi uygulanan ve cerrahi sırasından ön kamaradan aköz hü- mör örneği alınan PEX sendromu olmayan 17 göz (kontrol grubu) ve PEX olan 13 göz (PEX grubu) olmak üzere toplam 30 göz çalışmaya dahil edildi. Alınan humör aköz örneklerinde TNF-α ve nitrit/nitrat düzeyleri ölçüldü. Bulgular: Hastaların yaş ortalamaları kontrol grubunda 63.4±4 iken, PEX grubunda 61.3±2 yıldı (p>0.05). Kontrol gru- bundaki hastalarda kadın erkek oranı 8/9 iken, PEX grubunda 7/6 idi (p>0.05). Her iki grup karşılaştırıldığında, humör aköz TNF-α ve nitrit/nitrat düzeyleri arasında anlamlı bir fark saptanmadı (p>0.05). Sonuç: TNF-α ve nitrit/nitrat oksidatif stresin arttığı durumlarda artış gösterir ve pek çok oküler patolojiden sorumlu tu- tulur. Çalışmamızda TNF-α ve nitrit/nitrat’ın seviyeleri iki grupta benzer bulundu.

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Cite This Article

YILDIRIM, Z., UÇGUN, N. İ., KEMER, Ö. E., ŞEREFLİ, Ş. (2014). Humor aqueous tumor necrosis factor-α and nitric oxide levels in pseudoexfoliation syndrome. Glokom Katarakt, Cilt: 9 - Sayı: 1, 33–36. https://ajindex.com/articles/207798

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