Journals / Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi / 1998 / Cilt: 3 - Sayı: 4

In vitro activity of trovafloxacin against various microorganisms

Trovafloksasinin çeşitli mikroorganizmalara in vitro etkinliği

Pages
244–247
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Our results of the in vitro activity of trovafloxacin which will be used in our country in the near future are compared with those of other studies.

📌 3 Key Takeaways

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Objective & Hypothesis:In vitro activity of a new fluoroquinolone, trovafloxacin, was tested against 512 aerobic microorganisms by agar dilution method.
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Key Findings & Data:Minimum inhibitory concentration 50 and 90 (MIC50/MIC90) values for methicillin-sensiti-ve Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) were $\leq$ 0.03/0.06 $\mu$g/mL and 1/2 $\mu$g/mL, respectively.
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Conclusion & Impact:Our results of the in vitro activity of trovafloxacin which will be used in our country in the near future are compared with those of other studies.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

In vitro activity of a new fluoroquinolone, trovafloxacin, was tested against 512 aerobic microorganisms by agar dilution method. Methicillin-susceptible Staphylococcus aureus (MSSA), Escherichia coli, Proteus, Salmonella and Shigella species were isolated from patients hospitalized in various clinics. Klebsiella spp., Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA) were mainly the isolates of intensive care units. Minimum inhibitory concentration 50 and 90 (MIC50/MIC90) values for methicillin-sensiti-ve Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) were $\leq$ 0.03/0.06 $\mu$g/mL and 1/2 $\mu$g/mL, respectively. The same values for gram negative aerobic bacteria were as follows; Klebsiella spp. 0.12/4 $\mu$g/mL. P. aeruginosa 2/ $geq$ 16 $\mu$g/mL, E. coli $\leq$ 0.03/0.25 $\mu$g/mL, Proteus spp. 0.12/0.25 $\mu$g/mL, Salmonella and Shigella spp. $\leq$ 0.03/ $\leq$ 0.03 $\mu$g/mL. Our results of the in vitro activity of trovafloxacin which will be used in our country in the near future are compared with those of other studies.

Özet

Yeni bir florokinolon olan trovafloksasinin 512 aerop mikroorganizmaya in vitro etkinliği agar dilüsyon yöntemi ile araştırıldı. Metisilin duyarlı Staphylococcus aureus (MSSA), Escherichia coli, Proteus, Salmonella ve Shigella türleri çeşitli kliniklerde yatan hastalardan izole edilmişti. Klebsiella spp., Pseudomonas aeruginosa ve metisilin dirençli Staphylococcus aureus (MRSA) suşları ise esas olarak yoğun bakım izolatıydı. MSSA ve MRSA suşları için minimum inhibisyon konsantrasyon 50 ve 90 (MİK50/MİK90) değerleri sırasıyla $\leq$ 0.03/0.06 $\mu$g/mL ve 1/2 $\mu$g/mL olarak bulundu. Aynı değerler gram negatif aerop bakteriler için şöyleydi; Klebsiella türleri 0.12/4 $\mu$g/mL, P. aeruginosa 2/ $geq$ 16 $\mu$g/mL, E. coli $\leq$ 0.03/0.25 $\mu$g/mL, Proteus türleri 0.12/0.25 $\mu$g/mL, Salmonella ve Shigella türleri $\leq$ 0.03/ $\leq$ 0.03 $\mu$g/mL. Ülkemizde yakın bir gelecekte kullanıma sunulması beklenen trovafloksasinin in vitro etkinliğine ilişkin sonuçlarımız, başka çalışmalarla karşılaştırıldı.

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Cite This Article

ÇOKÇA, F., TUNCER, G., TEKELİ, E. (1998). In vitro activity of trovafloxacin against various microorganisms. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, Cilt: 3 - Sayı: 4, 244–247. https://ajindex.com/articles/224442

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References (1)

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