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Journals / Hipokrat Tıp Dergisi / 2026 / Cilt: 5 Sayı: 1

THE RELATIONSHIP BETWEEN INSULIN RESISTANCE AND VITAMIN D DEFICIENCY WITH BLOOD PARAMETERS

İNSÜLİN DİRENCİ VE VİTAMİN D EKSİKLİĞİNİN KAN PARAMETRELERİYLE İLİŞKİSİ

Hasan Esat Yücel(KIRŞEHİR AHİ EVRAN ÜNİVERSİTESİ)0000-0001-7788-0227
Naime Meric Konar(BANDIRMA ONYEDI EYLUL UNIVERSITY)0000-0002-6593-7617
Erkan Dulkadiroğlu(KIRŞEHİR AHİ EVRAN ÜNİVERSİTESİ)0000-0001-7665-7453
Pages
17–24
Publication Date
2025-04-29
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, while HOMA IR was positively related to MPV, 25 OH D was negatively associated with TSH.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: To investigate HOMA-IR and Vitamin D levels in patients complaining of weight gain and to idendify their relationship with blood parameters taken for examination.
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Key Findings & Data:Materials and Methods: There were a sum of 99 participants in the research (nmale = 25, nfemale = 74).
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Conclusion & Impact:However, while HOMA IR was positively related to MPV, 25 OH D was negatively associated with TSH.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:HOMA IR · Vitamin D · Açlık glukoz

Abstract

Aim: To investigate HOMA-IR and Vitamin D levels in patients complaining of weight gain and to idendify their relationship with blood parameters taken for examination. Materials and Methods: There were a sum of 99 participants in the research (nmale = 25, nfemale = 74). Fasting glucose and insulin, cholesterol, complete blood count, aspartate/alanine transaminase, thyroid stimulating hormone and 25-OH D levels were studied. Two different groups were created in the study. By calculating HOMA IR; those > 2.5 and above were placed in the insulin resistance group, while those 2.5 and 25 OH D <20. However, while HOMA IR was positively related to MPV, 25 OH D was negatively associated with TSH.

Özet

Amaç: Bu çalışmadaki amacımız kilo artışı şikayetiyle başvuran hastalarda HOMA-IR ve Vit D düzeylerini incelemek ve tetkik amaçlı alınan kan parametreleriyle ilişkisini araştırmaktır. Materyal & Metot: Çalışmaya 99 katılımcı dahil edildi(erkek=25, kadın =74).Tetkik olarak açlık glukoz ve insülin, kolesteroller, tam kan sayımı, aspartat/alanin transaminaz, tiroid stimülan hormon, 25-OH D düzeyleri çalışıldı. Çalışmada 2 farklı grup oluşturuldu. HOMA IR hesaplanarak ; > 2,5 ve üzeri insülin direnci grubuna alınırken, 25 OH D olanlar yeterli olarak kategorize edildi. Grupların sınıflamaya göre kan parametreleriyle korelasyonu incelendi. Bulgular: HOMA-IR’ye göre gruplar incelendiğinde İnsülin Dirençli grupta VKI,ALT TRG, Ferritin, AKG, İnsülin, HBG ve HCT değerleri daha yüksek bulunurken, HDL değerleri daha düşük bulundu (p< 0.05). HOMA IR ile MPV arasında anlamlı pozitif korelasyon saptandı(p< 0.05). 25 VitD yetersiz grupta VKI daha yüksek bulundu ve AKG ve TSH ile anlamlı negatif korelasyon izlendi (p< 0.05). Sonuçlar: İnsülin dirençli ve Vitamin D yetersizliği olan grupların her ikisi de artmış VKI ve açlık glukozuyla ilişkili bulundu. Bununla birlikte HOMA IR’ın MPV ile pozitif yönde korelasyonu saptanırken, 25 OH D’nin TSH ile negatif ilişkisi bulundu.

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Cite This Article

Yücel, H. E., Konar, N. M., Dulkadiroğlu, E. (2025). THE RELATIONSHIP BETWEEN INSULIN RESISTANCE AND VITAMIN D DEFICIENCY WITH BLOOD PARAMETERS. Hipokrat Tıp Dergisi, Cilt: 5 Sayı: 1, 17–24. https://doi.org/10.58961/hmj.1651475

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References (42)

  1. Gastaldelli A. Measuring and estimating insulin resistance in clinical and research settings. Obesity (Silver Spring). 2022 Aug;30(8):1549-1563. doi: 10.1002/oby.23503. PMID: 35894085; PMCID: PMC9542105.
  2. Zimmet P, Alberti KG, Shaw J. Global and societal implications of the diabetes epidemic. Nature. 2001 Dec 13;414(6865):782-7. doi: 10.1038/414782a. PMID: 11742409.
  3. Liu C, Shao M, Lu L, Zhao C, Qiu L, Liu Z. Obesity, insulin resistance and their interaction on liver enzymes. PLoS One. 2021 Apr 21;16(4):e0249299. doi: 10.1371/journal.pone.0249299. PMID: 33882064; PMCID: PMC8059853.
  4. Lee SH, Park SY, Choi CS. Insulin Resistance: From Mechanisms to Therapeutic Strategies. Diabetes Metab J. 2022 Jan;46(1):15-37. doi: 10.4093/dmj.2021.0280. Epub 2021 Dec 30. PMID: 34965646; PMCID: PMC8831809.
  5. Wallace TM, Utzschneider KM, Tong J, Carr DB, Zraika S, Bankson DD, Knopp RH, Kahn SE. Relationship of liver enzymes to insulin sensitivity and intra-abdominal fat. Diabetes Care. 2007 Oct;30(10):2673-8. doi: 10.2337/dc06-1758. Epub 2007 Jul 31. PMID: 17666458.
  6. Cruz MA, Cruz JF, Macena LB, de Santana DS, Oliveira CC, Lima SO, Franca AV. Association of the Nonalcoholic Hepatic Steatosis and Its Degrees With the Values of Liver Enzymes and Homeostasis Model Assessment Insulin Resistance Index. Gastroenterology Res. 2015 Oct;8(5):260-264. doi: 10.14740/gr685w. Epub 2015 Oct 21. PMID: 27785306;PMCID: PMC5051044.
  7. Li M, Zhang S, Wu Y, Ye J, Cao X, Liu J, Sun Y, Zhong B. Prevalence of Insulin Resistance in Subjects with Nonalcoholic Fatty Liver Disease and Its Predictors in a Chinese Population. Dig Dis Sci. 2015 Jul;60(7):2170-6. doi: 10.1007/s10620-015-3564-5. Epub 2015 Feb 17. PMID: 25686742.
  8. Sheng X, Che H, Ji Q, Yang F, Lv J, Wang Y, Xian H, Wang L. The Relationship Between Liver Enzymes and Insulin Resistance in Type 2 Diabetes Patients with Nonalcoholic Fatty Liver Disease. Horm Metab Res. 2018 May;50(5):397-402. doi: 10.1055/a-0603-7899. Epub 2018 May 3. PMID: 29723898.
  9. Simental-Mendía LE, Rodríguez-Morán M, Gómez-Díaz R, Wacher NH, Rodríguez-Hernández H, Guerrero-Romero F. Insulin resistance is associated with elevated transaminases and low aspartate aminotransferase/alanine aminotransferase ratio in young adults with normal weight. Eur J Gastroenterol Hepatol. 2017 Apr;29(4):435-440. doi: 10.1097/MEG.0000000000000811. PMID: 28009717.
  10. Garbossa SG, Folli F. Vitamin D, sub-inflammation and insulin resistance. A window on a potential role for the interaction between bone and glucose metabolism. Rev Endocr Metab Disord. 2017 Jun;18(2):243-258. doi: 10.1007/s11154-017-9423-2. PMID: 28409320.
  11. Chiu KC, Chu A, Go VL, Saad MF. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr. 2004 May;79(5):820-5. doi: 10.1093/ajcn/79.5.820. PMID: 15113720.
  12. Ganji V, Zhang X, Shaikh N, Tangpricha V. Serum 25-hydroxyvitamin D concentrations are associated with prevalence of metabolic syndrome and various cardiometabolic risk factors in US children and adolescents based on assay-adjusted serum 25-hydroxyvitamin D data from NHANES 2001-2006. Am J Clin Nutr. 2011 Jul;94(1):225-33. doi: 10.3945/ajcn.111.013516. Epub 2011 May 25. PMID: 21613551.
  13. Dutta D, Maisnam I, Shrivastava A, Sinha A, Ghosh S, Mukhopadhyay P, Mukhopadhyay S, Chowdhury S. Serum vitamin-D predicts insulin resistance in individuals with prediabetes. Indian J Med Res. 2013 Dec;138(6):853-60. PMID: 24521626; PMCID: PMC3978972.
  14. Heaney RP, French CB, Nguyen S, Ferreira M, Baggerly LL, Brunel L, Veugelers P. A novel approach localizes the association of vitamin D status with insulin resistance to one region of the 25-hydroxyvitamin D continuum. Adv Nutr. 2013 May 1;4(3):303-10. doi: 10.3945/an.113.003731. PMID: 23674796; PMCID: PMC3650499.
  15. Gallagher JC, Yalamanchili V, Smith LM. The effect of vitamin D supplementation on serum 25(OH)D in thin and obese women. J Steroid Biochem Mol Biol. 2013 Jul;136:195-200. doi: 10.1016/j.jsbmb.2012.12.003. Epub 2012 Dec 11. PMID: 23246640; PMCID: PMC3686842.
  16. Peng H, Xiang J, Pan L, Zhao M, Chen B, Huang S, Yao Z, Liu J, Lv W. METS-IR/HOMA-IR and MAFLD in U.S. adults: doseresponse correlation and the effect mediated by physical activity. BMC Endocr Disord. 2024 Aug 1;24(1):132. doi: 10.1186/s12902-024-01646-w. PMID: 39085855; PMCID: PMC11293050
  17. Macdonald IA. A review of recent evidence relating to sugars, insulin resistance and diabetes. Eur J Nutr. 2016 Nov;55(Suppl 2):17-23. doi: 10.1007/s00394-016-1340-8. Epub 2016 Nov 23. PMID: 27882410; PMCID: PMC5174139.
  18. Chen Z, Franco OH, Lamballais S, Ikram MA, Schoufour JD, Muka T, Voortman T. Associations of specific dietary protein with longitudinal insulin resistance, prediabetes and type 2 diabetes: The Rotterdam Study. Clin Nutr. 2020 Jan;39(1):242-249. doi: 10.1016/j.clnu.2019.01.021. Epub 2019 Jan 31. PMID: 30739809.
  19. Wang K, Gong M, Xie S, Zhang M, Zheng H, Zhao X, Liu C. Nomogram prediction for the 3-year risk of type 2 diabetes in healthy mainland China residents. EPMA J. 2019 Aug 6;10(3):227-237. doi: 10.1007/s13167-019 00181-2. PMID: 31462940; PMCID: PMC6695459.
  20. Feingold KR. Dyslipidemia in diabetes. In: Endotext. South Dartmouth MDText.com, Inc, 2000.doi:10.1016/s0002-9149(02) 02553-5. [Google Scholar
  21. Tang X, Yan X, Zhou H, Huang G, Niu X, Jiang H, Su H, Yang X, Li X, Zhou Z. Associations of insulin resistance and beta-cell function with abnormal lipid profile in newly diagnosed diabetes. Chin Med J (Engl). 2022 Nov 5;135(21):2554-2562. doi: 10.1097/CM9.0000000000002075. PMID: 35245924; PMCID: PMC9944004.
  22. Boursier G, Sultan A, Molinari N, Maimoun L, Boegner C, Picandet M, Kuster N, Bargnoux AS, Badiou S, Dupuy AM, Cristol JP, Avignon A. Triglycerides and glycated hemoglobin for screening insulin resistance in obese patients. Clin Biochem. 2018 Mar;53:8-12. doi: 10.1016/j.clinbiochem.2017.12.002. Epub 2017 Dec 7. PMID: 29225096.
  23. Miyagawa S, Kobayashi M, Konishi N, Sato T, Ueda K. Insulin and insulin-like growth factor I support the proliferation of erythroid progenitor cells in bone marrow through the sharing of receptors. Br J Haematol. 2000 Jun;109(3):555-62. doi: 10.1046/j.1365-2141.2000.02047.x. PMID: 10886204.
  24. Jin YZ, Zheng DH, Duan ZY, Lin YZ, Zhang XY, Wang JR, Han S, Wang GF, Zhang YJ. Relationship Between Hematocrit Level and Cardiovascular Risk Factors in a Community-Based Population. J Clin Lab Anal. 2015 Jul;29(4):289-93. doi: 10.1002/jcla.21767. Epub 2014 May 21. PMID: 24849556; PMCID: PMC6807177.
  25. Ferreira D, Severo M, Araújo J, Barros H, Guimarães JT, Ramos E. Association between insulin resistance and haematological parameters: A cohort study from adolescence to adulthood. Diabetes Metab Res Rev. 2019 Nov;35(8):e3194. doi: 10.1002/dmrr.3194. Epub 2019 Jul 16. PMID: 31206976.
  26. Suárez-Ortegón MF, McLachlan S, Wild SH, Fernández-Real JM, Hayward C, Polašek O. Soluble transferrin receptor levels are positively associated with insulin resistance but not with the metabolic syndrome or its individual components. Br J Nutr. 2016 Oct;116(7):1165-1174. doi: 10.1017/S0007114516002968. Epub 2016 Sep 8. PMID: 27605239; PMCID: PMC5860738.
  27. Nakamura K, Sakurai M, Morikawa Y, Nagasawa SY, Miura K, Ishizaki M, Kido T, Naruse Y, Nakashima M, Nogawa K, Suwazono Y, Nakagawa H. Serum Ferritin, Insulin Resistance, and β-cell Dysfunction: A Prospective Study in Normoglycemic Japanese Men. Exp Clin Endocrinol Diabetes. 2017 Jan;125(1):12-20. doi: 10.1055/s-0042-118175. Epub 2016 Oct 17. PMID: 27750351.
  28. Zhang Y, Lu X, Hong J, Chao M, Gu W, Wang W, Ning G. Positive correlations of liver enzymes with metabolic syndrome including insulin resistance in newly diagnosed type 2 diabetes mellitus. Endocrine. 2010 Oct;38(2):181-7. doi: 10.1007/s12020-010-9369-6. Epub 2010 Oct 23. PMID: 20972737.
  29. Parrinello CM, Rudolph BJ, Lazo M, Gallo LC, Thyagarajan B, Cotler SJ, Qi Q, Seeherunvong T, Vidot DC, Strickler HD, Kaplan RC, Isasi CR. Associations of Insulin Resistance and Glycemia With Liver Enzymes in Hispanic/Latino Youths: Results From the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth). J Clin Gastroenterol. 2019 Feb;53(2):e46-e53. doi: 10.1097/MCG.0000000000000946. PMID: 29099463; PMCID: PMC5934331.
  30. Ateş, M. S., Keleş, F., Yıldırım, A., Kök, Z., et al. (2024). The Impact of Smoking on Platelet Indices Among Acute Myocardial Infarction Patients. Ahi Evran Medical Journal, 8(3), 342-347. https://doi.org/10.46332/aemj.1452480
  31. Watanabe Y, Kawada M, Kobayashi B. Effect of insulin on murine megakaryocytopoiesis in a liquid culture system. Cell Struct Funct. 1987 Jun;12(3):311-6. doi: 10.1247/csf.12.311. PMID: 3304669.
  32. Baldane S, Ipekci SH, Kebapcilar A. Relationship Between Insulin Resistance and Mean Platelet Volume in Gestational Diabetes Mellitus. J Lab Physicians. 2015 Jul-Dec;7(2):112-5. doi: 10.4103/0974-2727.163134. PMID: 26417162; PMCID: PMC4559623.
  33. Varol E, Akcay S, Ozaydin M, Erdogan D, Dogan A, Altinbas A. Mean platelet volume is associated with insulin resistance in non-obese, non-diabetic patients with coronary artery disease. J Cardiol. 2010 Sep;56(2):154-8. doi: 10.1016/j.jjcc.2010.03.005. Epub 2010 Apr 28. PMID: 20430587.
  34. Zuluaga P, Casado-Carbajo J, Hernández-Rubio A, BuenoVélez M, García-Martin C, Muga R, Fuster D. Vitamin D Deficiency Is Associated with Advanced Liver Fibrosis and Impaired Fasting Glucose in Alcohol Use Disorder. Nutrients. 2024 Apr 9;16(8):1099. doi: 10.3390/nu16081099. PMID: 38674789; PMCID: PMC11054091.
  35. Yucel, Hasan Esat,Erbesler, Zeynel Abidin, Tur Kaan, Celiker Mesut, Konar Naime Meric,Ucar Cahit.Vitamin D deficiency and clinical severity of Covid-19 infection.Ann MedRes 2022;29(2):134–138.DOI 10.5455/annalsmedres.2021.04.360
  36. Abukanna AMA, Alanazi RFA, Alruwaili FS, Alayyashi AZM, Alanzi F. Vitamin D Deficiency as a Risk Factor for Diabetes and Poor Glycemic Control in Saudi Arabia: A Systematic Review. Cureus. 2023 Nov 9;15(11):e48577. doi: 10.7759/cureus.48577. PMID: 38073984; PMCID: PMC10710317.
  37. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002 Dec 17;106(25):3143-421. PMID: 12485966.
  38. Shimmi SC, Eldosouky HF, Hossain Parash MT, Wan Saudi WS. Probability of Concurrent Deficiency of Vitamin D and Iron in Hypothyroidism: A Cross-Sectional Study. Cureus. 2023 Apr 5;15(4):e37152. doi: 10.7759/cureus.37152. PMID: 37153231; PMCID: PMC10161284.
  39. Appunni S, Rubens M, Ramamoorthy V, Saxena A, Tonse R, Veledar E, McGranaghan P. Association between vitamin D deficiency and hypothyroidism: results from the National Health and Nutrition Examination Survey (NHANES) 2007-2012. BMC Endocr Disord. 2021 Nov 12;21(1):224. doi: 10.1186/s12902-021-00897-1. PMID: 34772378; PMCID: PMC8590325.
  40. Beshboosh NN, Abd Alaali ZF, Mohammed MH.Relation between vitamin D deficiency and physiological blood parameters in hypothyroidism patients. https://www.researchgate.net/publication/331718544_REL ATIONSHIP_BETWEEN_VITAMIN_D_DEFICIENCY_AND_PHYSIOLOGICAL_BLOOD_PARAMETERS_IN_HYPOTHYROIDISM_PATIENTS Biochem Cell Arch. 2018;18:465–470
  41. Islam T, Choudhury S, Datta A.A study of vit. D levels in hypothyroid patients, a case control study in a tertiary care hospital of central India. J Evid Based Med Healthc. 2019;6:965–967.
  42. Shankar M, Singh M. Is there any association between serum 25 (OH) vitamin D3 level and hypothyroidism among females: a cross sectional study?https://ijshr.com/IJSHR_Vol.5_Issue.3_July2020/IJSHR0027.p df Int J Sci Healthcare Res. 2020;5:180–185