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Journals / Bingöl Üniversitesi Sağlık Dergisi / 2026 / Cilt: 6 Sayı: 1

Microbial Perspective on Cancer: Postbiotics

Kansere Mikrobiyal Bakış: Postbiyotikler

Mert Aşit(Yalova Government Hospital)0000-0003-2040-6924
Hasan Ergenç(Ayancık Government Hospital)0000-0003-0519-0264
Sinem Uysal(Bandırma Onyedi Eylül Üniversitesi)0009-0006-7279-8789
Pages
151–160
Publication Date
2025-04-26
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This review was written to examine the effects of postbiotics on some types of cancer.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Cancer is the second leading cause of death worldwide.
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Key Findings & Data:Although there has been positive progress in the prognosis of cancer patients with developing treatment methods, it is still poor in the majority of cases.
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Conclusion & Impact:This review was written to examine the effects of postbiotics on some types of cancer.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Gastrointestinal kanser · Mikrobiyal yaşayabilirlik · Oral kanser.

Abstract

Cancer is the second leading cause of death worldwide. Although there has been positive progress in the prognosis of cancer patients with developing treatment methods, it is still poor in the majority of cases. Complex approaches to anticancer treatment encourage researchers to seek new ways in this regard. Intestinal microbiota is one of the large areas that need to be investigated for this purpose. Microbiota has an important place in the human body. Dysbiosis, which occurs as a result of imbalance in microbial composition, can trigger some types of cancer by affecting the tumorigenic pathway. Probiotics, prebiotics, synbiotics and postbiotics can help restore the microbiota balance by affecting the intestinal microbiota. The use of postbiotics, a member of the biotic family for the intestinal microbiome, has recently attracted attention. Postbiotics are microbial metabolites that have beneficial effects on host health. Postbiotics have antibacterial, anticancer and anticarcinogenic properties that potentially help prevent or treat some types of cancer. With these effects, postbiotics are very important on cancer. This review was written to examine the effects of postbiotics on some types of cancer.

Özet

Dünya genelinde meydana gelen ölümlerin nedenleri arasında kanser ikinci sırada yer almaktadır. Gelişmekte olan tedavi yöntemleri ile kanser hastalarının prognozunda olumlu yönde ilerleme kat edilmiş olsada vakaların büyük bir kısmında hala daha kötüdür. Antikanser tedavisine olan karmaşık yaklaşımlar araştırmacıları bu konuda da yeni yollar aramaya teşvik etmektedir. Bağırsak mikrobiyotası bu amaçla araştırılması gereken geniş alanlardan biridir. Mikrobiyotanın insan vücudunda önemli bir yeri vardır. Mikrobiyal kompozisyonun dengesizleşmesi sonucu meydana gelen disbiyosiz tümorijenik yolu etkileyerek bazı kanser türlerini tetikleyebilir. Probiyotikler, prebiyotikler, sinbiyotikler ve postbiyotikler bağırsak mikrobiyotasını etkileyerek mikrobiyota dengesinin yeniden sağlanmasına yardımcı olabilmektedir. Bağırsak mikrobiyomu için biyotik ailesinin bir üyesi olan postbiyotiklerin kullanımı son zamanlarda ilgi çekmektedir. Postbiyotikler konakçı sağlığına faydalı etkileri bulunan mikrobiyal metabolitlerdir. Postbiyotikler bazı kanser türlerini önleme veya tedavisine potansiyel olarak yardımcı olan antibakteriyel, antikanser ve antikanserojenik özelliklere sahiptir. Bu etkileri ile postbiyotikler kanser üzerinde oldukça önemlidir. Bu derleme postbiyotiklerin bazı kanser türleri üzerine etkilerini incelemek amacıyla yazılmıştır.

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Cite This Article

Aşit, M., Ergenç, H., Uysal, S. (2025). Microbial Perspective on Cancer: Postbiotics. Bingöl Üniversitesi Sağlık Dergisi, Cilt: 6 Sayı: 1, 151–160. https://doi.org/10.58605/bingolsaglik.1600034

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