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Journals / Scientific Journal of Mehmet Akif Ersoy University / 2020 / Volume: 3 Issue: 3

Determination of the impacts of titanium dioxide nanoparticles on a number of xenobiotic-metabolizing enzymes in rat liver

Ayça Taş(Sivas Cumhuriyet Üniversitesi-Sağlık Bilimleri Fakültesi)0000-0002-7132-1325
Neşe Keklikcioğlu Çakmak(SİVAS CUMHURİYET ÜNİVERSİTESİ)0000-0002-8634-9232
Tuğba Agbektaş(SİVAS CUMHURİYET ÜNİVERSİTESİ)0000-0003-3433-8870
Cemile Zontul(SİVAS CUMHURİYET ÜNİVERSİTESİ)0000-0002-1436-5145
Esma Özmen(NİĞDE ÖMER HALİSDEMİR ÜNİVERSİTESİ)0000-0003-3223-6854
Yavuz Siliğ(SİVAS CUMHURİYET ÜNİVERSİTESİ)0000-0002-0562-7457
Pages
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Publication Date
2020-12-31
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Therefore, this inhibition can affect the detoxification system negatively.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Nanotechnology techniques are used in many applications, such as cancer treatment, radiological imaging methods, and pharmaceutical industry, as well as in the microbiology field, tissue regeneration, injury healing, treatment of some chronic diseases, and production of vaccines.
📊
Key Findings & Data:This study’s goal was to reveal the impacts of titanium dioxide (TiO2) nanoparticles on a number of xenobiotic-metabolizing enzymes in the rat liver fraction.
💡
Conclusion & Impact:Therefore, this inhibition can affect the detoxification system negatively.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Xenobiotic-Metabolizing Enzymes · Titanium Dioxide · Nanoparticles

Abstract

Nanotechnology techniques are used in many applications, such as cancer treatment, radiological imaging methods, and pharmaceutical industry, as well as in the microbiology field, tissue regeneration, injury healing, treatment of some chronic diseases, and production of vaccines. Whereas products of nanotechnology have a lot of benefits mentioned in our life, they also have some systemic, genetic, and toxic effects in organisms. This study’s goal was to reveal the impacts of titanium dioxide (TiO2) nanoparticles on a number of xenobiotic-metabolizing enzymes in the rat liver fraction. In the current research, adult Wistar albino rats having a weight of approximately 150-200 g and fed under normal conditions were utilized. The incubation of four various concentrations of TiO2 nanoparticles (0.5, 1, 5, and 10 ppm) was performed in the liver fractions. We studied the effects of TiO2 nanoparticles on some enzymes identified in the microsomal fraction, such as N-nitrosodimethylamine demethylase (cytochrome P4502E1), NADPH cytochrome c reductase, NADH cytochrome b5 reductase, and other enzymes found in the cytosolic fraction, e.g. glutathione-S-transferase (GST), glucose-6-phosphate dehydrogenase (G6PDH), and glutathione level (GSH). GST, G6PDH, NADH-cytochrome b5 reductase, and NADPH cytochrome c reductase levels decreased statistically significantly, whereas the GSH level increased significantly in comparison with controls (p 0.05). Accordingly, in this study, we have shown that TiO2 nanoparticles are capable of inhibiting xenobiotic-metabolizing enzymes. Therefore, this inhibition can affect the detoxification system negatively.

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Cite This Article

Taş, A., Çakmak, N. K., Agbektaş, T., Zontul, C., Özmen, E., Siliğ, Y. (2020). Determination of the impacts of titanium dioxide nanoparticles on a number of xenobiotic-metabolizing enzymes in rat liver. Scientific Journal of Mehmet Akif Ersoy University, Volume: 3 Issue: 3. https://ajindex.com/articles/1540594

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