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Journals / International Journal of Chemistry and Technology / 2019 / Volume: 3 Issue: 2

Cytotoxic activity of zinc oxide/titanium dioxide nanoparticles on prostate cancer cells

Ayca Tas(Sivas Cumhuriyet University, Faculty of Health Sciences Department of Nutrition and Dietetics, Sivas,Turkey)0000-0002-7132-1325
Nese Keklikcioglu Cakmak(Sivas Cumhuriyet University, Faculty of Engineering, Department of Chemical Engineering, Sivas,Turkey)0000-0002-8634-9232
Tugba Agbektas(Sivas Cumhuriyet University, Faculty of Medicine, Department of Biochemistry, Sivas, Turkey)0000-0003-3433-8870
Yavuz Silig(Sivas Cumhuriyet University, Faculty of Medicine, Department of Biochemistry, S ivas, Turkey)0000-0002-0562-7457
Pages
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Publication Date
2019-12-31
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

TiO2 + ZnO NC in the Du-145 cell line was found as the most active, having statistically significant (***p < 0.0001, **p ˂ 0.001 and **p ˂ 0.01).

📌 3 Key Takeaways

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Objective & Hypothesis:Prostate cancer is caused by uncontrolled growth of cells in the prostate gland.
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Key Findings & Data:The aim of this study was to determine the cytotoxic activity of titanium dioxide (TiO 2 ) and zinc oxide (ZnO) nanoparticles (NPs) and TiO 2 + ZnO nanocomposite (NC) in human prostate cancer cell line (DU-145) and healthy mouse fibroblast cell line (L-929).
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Conclusion & Impact:TiO2 + ZnO NC in the Du-145 cell line was found as the most active, having statistically significant (***p < 0.0001, **p ˂ 0.001 and **p ˂ 0.01).
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Prostate cancer · Du-145 · L-929

Abstract

Prostate cancer is caused by uncontrolled growth of cells in the prostate gland. The aim of this study was to determine the cytotoxic activity of titanium dioxide (TiO 2 ) and zinc oxide (ZnO) nanoparticles (NPs) and TiO 2 + ZnO nanocomposite (NC) in human prostate cancer cell line (DU-145) and healthy mouse fibroblast cell line (L-929). In the study, TiO 2 and ZnO NPs and TiO 2 + ZnO NC were synthesized. Cytotoxic activities of NC and NPs was then analyzed in human prostate cancer cell line (DU-145) and healthy mouse fibroblast cell lines (L-929) using the MTT method. TiO 2 , ZnO and TiO 2 + ZnO IC 50 values were determined in DU-145 and L-929 cell cells (n = 6). TiO2 + ZnO NC in the Du-145 cell line was found as the most active, having statistically significant (***p < 0.0001, **p ˂ 0.001 and **p ˂ 0.01).

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Cite This Article

Tas, A., Cakmak, N. K., Agbektas, T., Silig, Y. (2019). Cytotoxic activity of zinc oxide/titanium dioxide nanoparticles on prostate cancer cells. International Journal of Chemistry and Technology, Volume: 3 Issue: 2. https://doi.org/10.32571/ijct.613536

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