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Journals / Animal Health Production and Hygiene / 2026 / Cilt: 15 Sayı: 1

Evaluation of the Anesthetic Efficacy of the Medetomidine–Butorphanol–Ketamine Combination (Kitty Magic) in Cats

Kedilerde Medetomidin–Butorfanol–Ketamin Kombinasyonunun (Kitty Magic) Anestezik Etkinliğinin Değerlendirilmesi

Gülşah Yılmaz Günel(AYDIN ADNAN MENDERES ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ)0000-0003-0767-0915
Eser Çakmakçı(AYDIN ADNAN MENDERES ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ)0000-0001-5784-6291
Büşra Kibar(AYDIN ADNAN MENDERES ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ)0000-0002-1490-8832
Ali Belge(AYDIN ADNAN MENDERES ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ)0000-0003-3346-6926
Pages
6–12
Publication Date
2026-03-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Owing to its simplicity, cost-effectiveness, and reversibility, this protocol represents a safe and practical alternative for feline castration and similar short-duration surgical procedures, particularly in shelters and clinical settings lacking inhalation anesthesia equipment.

📌 3 Key Takeaways

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Objective & Hypothesis:This study aimed to evaluate the anesthetic efficacy, physiological stability, and postoperative analgesia of the medetomidine–butorphanol–ketamine combination (Kitty Magic) in cats undergoing routine castration.
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Key Findings & Data:Twenty clinically healthy male cats of different breeds and weights were anesthetized using a single intramuscular injection of the combination at a dose of 0.02–0.08 mL/kg.
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Conclusion & Impact:Owing to its simplicity, cost-effectiveness, and reversibility, this protocol represents a safe and practical alternative for feline castration and similar short-duration surgical procedures, particularly in shelters and clinical settings lacking inhalation anesthesia equipment.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:İmidazoller · Kediler · Morfinanlar

Abstract

This study aimed to evaluate the anesthetic efficacy, physiological stability, and postoperative analgesia of the medetomidine–butorphanol–ketamine combination (Kitty Magic) in cats undergoing routine castration. Twenty clinically healthy male cats of different breeds and weights were anesthetized using a single intramuscular injection of the combination at a dose of 0.02–0.08 mL/kg. Sedation occurred within 4.15 ± 2.13 minutes, and surgical anesthesia lasted 43.85 ± 8.78 minutes, with total anesthesia time averaging 59.65 ± 9.03 minutes. Mean times to sternal recumbency and standing were 57.25 ± 10.89 and 60.85 ± 16.80 minutes, respectively. The protocol produced significant but clinically acceptable decreases in heart rate, respiratory rate, and body temperature, remaining within physiological limits. No complications such as vomiting, urination, or excitation were observed. Postoperative pain scores, assessed using a simple descriptive scale, indicated minimal discomfort, with 90% of cats scoring 0. Atipamezole administered at the end of surgery reversed anesthesia within 12.11 ± 5.47 minutes, ensuring smooth recovery. The findings demonstrate that the Kitty Magic combination provides reliable anesthesia with adequate depth, muscle relaxation, and analgesia while maintaining cardiovascular stability. Owing to its simplicity, cost-effectiveness, and reversibility, this protocol represents a safe and practical alternative for feline castration and similar short-duration surgical procedures, particularly in shelters and clinical settings lacking inhalation anesthesia equipment.

Özet

Bu çalışma, rutin orşiektomi operasyonu geçiren kedilerde medetomidin–butorfanol–ketamin kombinasyonunun (Kitty Magic) anestezik etkinliğini, fizyolojik stabilite üzerindeki etkilerini ve postoperatif analjezik etkinliğini değerlendirmek amacıyla gerçekleştirildi. Farklı ırk, yaş ve vücut ağırlıklarına sahip, klinik olarak sağlıklı 20 erkek kediye 0,02–0,08 mL/kg dozunda tek intramüsküler enjeksiyon uygulandı. Ortalama sedasyon süresi 4,15 ± 2,13 dakika, cerrahi anestezi süresi 43,85 ± 8,78 dakika ve toplam anestezi süresi 59,65 ± 9,03 dakika olarak belirlendi. Kedilerin sternal pozisyona gelme süresi 57,25 ± 10,89 dakika, ayağa kalkma süresi ise 60,85 ± 16,80 dakika olarak kaydedildi. Kalp atım hızı, solunum sayısı ve vücut ısısında istatistiksel olarak anlamlı ancak klinik olarak tolere edilebilir düşüşler gözlendi. Kusma, ürinasyon veya eksitasyon gibi komplikasyonlara rastlanmadı. Postoperatif ağrı değerlendirmesi, Basit Tanımlayıcı Ölçek (Simple Descriptive Scale) kullanılarak yapıldı ve olguların %90’ında ağrı skoru “0” olarak belirlendi. Operasyon sonunda uygulanan atipamezol enjeksiyonu, ortalama 12,11 ± 5,47 dakika içinde tam uyanma sağladı. Elde edilen bulgular, Kitty Magic kombinasyonunun kedilerde güvenilir bir anestezi sağladığını, yeterli kas gevşemesi ve analjezi oluşturduğunu, kardiyorespiratuar stabiliteyi koruduğunu göstermektedir. Basit uygulama şekli, ekonomik oluşu ve atipamezol ile kolaylıkla geri döndürülebilmesi nedeniyle, bu protokolün barınak ve klinik koşullarda kısa süreli cerrahi girişimler için pratik ve güvenli bir alternatif olduğu sonucuna varılmıştır.

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Cite This Article

Günel, G. Y., Çakmakçı, E., Kibar, B., Belge, A. (2026). Evaluation of the Anesthetic Efficacy of the Medetomidine–Butorphanol–Ketamine Combination (Kitty Magic) in Cats. Animal Health Production and Hygiene, Cilt: 15 Sayı: 1, 6–12. https://doi.org/10.53913/aduveterinary.1810402

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