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Dergiler / Journal of Experimental and Clinical Medicine / 2013 / Cilt: 30 - Sayı: 2

The stereological ratio of stromal/parenchymal components in postnatal prostate tissue of rats prenatally treated with diclofenac sodium

Mikail KARA
Cennet RAĞBETLİ
Necat KOYUN
Neşe ÇÖLÇİMEN
Murat RAĞBETLİ
Sayfa
171–174
Yayın Tarihi
2013-07-31
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Prenatally applied diclofenac sodium did not cause a statistically significant change in the prostate stroma parenchymal ratio in 20-week old rats compared to the control animals (p>0.05).

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Amaç & Hipotez:Since diclofenac sodium extends the pregnancy and affects the fetus, our study aimed to stereologically investigate the components of the rat prostate with prenatally treated with diclofenac sodium.
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Temel Bulgular & Veri:After injections to sham and treated groups for 15 days, 18 male offsprings were housed in three groups (6 placebo; 6 control; 6 treated).
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Sonuç & Katkı:Prenatally applied diclofenac sodium did not cause a statistically significant change in the prostate stroma parenchymal ratio in 20-week old rats compared to the control animals (p>0.05).
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Diclofenac sodium · Prenatal term · Rat

Abstract

Since diclofenac sodium extends the pregnancy and affects the fetus, our study aimed to stereologically investigate the components of the rat prostate with prenatally treated with diclofenac sodium. The rats were left overnight to mate. Pregnant animals were kept in a room tempreture with normal light and dark cycles and fed with normal diet. After injections to sham and treated groups for 15 days, 18 male offsprings were housed in three groups (6 placebo; 6 control; 6 treated). The 20 weeks-old animals were perfused and the prostates removed and embedded in paraffin. Tissue sections at 5μm thickness were taken at regular intervals and stained with Hematoxylin-eosin and Masson trichrome. Cavalieri principle was used for volume fractions analysis. Stereological examination revealed 55% acinar epitelium and 45% connective tissue in both control and placebo groups, as well as 60% acinar epitelium and 40% connective tissue in the treated group. Prenatally applied diclofenac sodium did not cause a statistically significant change in the prostate stroma parenchymal ratio in 20-week old rats compared to the control animals (p>0.05).

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Bu Makaleye Atıf Yap

KARA, M., RAĞBETLİ, C., KOYUN, N., ÇÖLÇİMEN, N., RAĞBETLİ, M. (2013). The stereological ratio of stromal/parenchymal components in postnatal prostate tissue of rats prenatally treated with diclofenac sodium. Journal of Experimental and Clinical Medicine, Cilt: 30 - Sayı: 2, 171–174. https://ajindex.com/articles/678643

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