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Dergiler / Journal of Experimental and Clinical Medicine / 2026 / Volume: 43 Issue: 3

Post-infantile giant cell hepatitis secondary to autoimmune hepatitis: A rare case report

Eylem Yaren Yılmaz(ONDOKUZ MAYIS UNIVERSITY, SCHOOL OF MEDICINE)0000-0001-5697-4961
Omer Kucukdemırcı(ONDOKUZ MAYIS UNIVERSITY, SCHOOL OF MEDICINE)0000-0001-7642-2793
İbrahim Gören(ONDOKUZ MAYIS UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-9985-1811
Bilge Can(ONDOKUZ MAYIS UNIVERSITY, SCHOOL OF MEDICINE)0000-0001-8324-0154
Ufuk Avcıoğlu(ONDOKUZ MAYIS UNIVERSITY, SCHOOL OF MEDICINE)0000-0001-6905-4494
Sayfa
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Yayın Tarihi
2026-09-30
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Correct recognition is clinically relevant because it directs clinicians to initiate immunosuppressive therapy early and search for concurrent autoimmune diseases.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Giant cell transformation of hepatocytes in adults is a rare histological finding, historically labelled as post infantile giant cell hepatitis (PIGCH).
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Temel Bulgular & Veri:We report a case of a 46-year-old man with autoimmune hepatitis (AIH) presenting as diffuse giant cell transformation who achieved remission with prednisolone and azathioprine.
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Sonuç & Katkı:Correct recognition is clinically relevant because it directs clinicians to initiate immunosuppressive therapy early and search for concurrent autoimmune diseases.
🔬Tür:Case Report
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:autoimmune hepatitis · giant cell hepatitis · Immune thrombocytopenic purpura

Abstract

Giant cell transformation of hepatocytes in adults is a rare histological finding, historically labelled as post infantile giant cell hepatitis (PIGCH). Increasing evidence suggests that it represents a morphological variant of several underlying liver diseases rather than a distinct, nosologically entity. We report a case of a 46-year-old man with autoimmune hepatitis (AIH) presenting as diffuse giant cell transformation who achieved remission with prednisolone and azathioprine. This case highlights the importance of recognizing giant cell transformation as a histologic pattern that should prompt a thorough etiologic work-up and consideration of AIH to avoid misdiagnosis. Correct recognition is clinically relevant because it directs clinicians to initiate immunosuppressive therapy early and search for concurrent autoimmune diseases.

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Bu Makaleye Atıf Yap

Yılmaz, E. Y., Kucukdemırcı, O., Gören, İ., Can, B., Avcıoğlu, U. (2026). Post-infantile giant cell hepatitis secondary to autoimmune hepatitis: A rare case report. Journal of Experimental and Clinical Medicine, Volume: 43 Issue: 3. https://ajindex.com/articles/1422502

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Kaynakça (18)

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