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Dergiler / Journal of Experimental and Clinical Medicine / 2021 / Cilt: 38 - Sayı: 2

Study on the effect of maternal administration of oxaliplatin on offspring testes using unbiased design-based stereology

Javad SADEGHİNEZHAD
Moslem DAHMARDEH
Zahra TOOTİAN
Hadis BOJARZADEH
Fatemeh YARMAHMOUDİ
Sayfa
99–106
Yayın Tarihi
2021-04-03
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Due to the ameliorating effect of Ox on offspring testes, cautiousness is needed during maternal administration in order to preserve the fertility of male offspring.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Oxaliplatin (Ox) is widely used for the treatment of various tumors.
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Temel Bulgular & Veri:The control group (1) was administered intraperitoneally 0.2 ml of saline three times a week for the 21 days of pre-pregnancy, pregnancy and lactation.
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Sonuç & Katkı:Due to the ameliorating effect of Ox on offspring testes, cautiousness is needed during maternal administration in order to preserve the fertility of male offspring.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Oxaliplatin · Perinatal administration · Stereology

Abstract

Oxaliplatin (Ox) is widely used for the treatment of various tumors. Since Ox prevents DNA replication and transcription, it may affect organs with rapid cell divisions such as the testes. Although its use during pregnancy has been reported, no information regarding its effects on the testes of the offspring is not available yet. Thirty-two mice were randomly divided into four groups. The control group (1) was administered intraperitoneally 0.2 ml of saline three times a week for the 21 days of pre-pregnancy, pregnancy and lactation. Experimental groups 2, 3 and 4 received 3 mg/kg of oxaliplatin three times a week for 21 days during pre-pregnancy, pregnancy and lactation, respectively. The left testis was removed from male offspring 30 and 60 days after birth. The volume of the testes, seminiferous tubules and interstitial tissue, the surface area and height of the seminiferous epithelium, as well as the length and diameter of seminiferous tubules, were analyzed by means of stereology. Results showed a decrease in the evaluated parameters in experimental groups, in comparison with the control group. Due to the ameliorating effect of Ox on offspring testes, cautiousness is needed during maternal administration in order to preserve the fertility of male offspring.

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Bu Makaleye Atıf Yap

SADEGHİNEZHAD, J., DAHMARDEH, M., TOOTİAN, Z., BOJARZADEH, H., YARMAHMOUDİ, F. (2021). Study on the effect of maternal administration of oxaliplatin on offspring testes using unbiased design-based stereology. Journal of Experimental and Clinical Medicine, Cilt: 38 - Sayı: 2, 99–106. https://ajindex.com/articles/678026

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Kaynakça (9)

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