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Dergiler / İstanbul Journal of Pharmacy / 2022 / Cilt: 52 - Sayı: 1

Chemical constituent of Isochrysis galbana microalgae extract and its cytotoxic activities on leukemic cell lines

Belkis ATASEVER ARSLAN
Kaan YILANCIOĞLU
Seda KUŞOĞLU GÜLTEKİN
İrem Gülfem ALBAYRAK
Sayfa
64–68
Yayın Tarihi
2022-04-28
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The investigation of the effect of these molecules specifically against Raji cells is important to determine the possible anti-leukemic molecules and their combinations that show cytotoxicity against this cell line.

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Amaç & Hipotez:Background and Aims: This study was aimed to investigate the anti-cancer effect of Isochrysis galbana microalgae extract.
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Temel Bulgular & Veri:Methods: In the study, the chemical composition of Isochrysis galbana microalgae extract was analyzed, and its cytotoxic effect against K562, HL60, U937, MOLT-4, and Raji cancer cells was investigated.
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Sonuç & Katkı:The investigation of the effect of these molecules specifically against Raji cells is important to determine the possible anti-leukemic molecules and their combinations that show cytotoxicity against this cell line.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Microalgae · Cancer · Cytotoxicity

Abstract

Background and Aims: This study was aimed to investigate the anti-cancer effect of Isochrysis galbana microalgae extract. Methods: In the study, the chemical composition of Isochrysis galbana microalgae extract was analyzed, and its cytotoxic effect against K562, HL60, U937, MOLT-4, and Raji cancer cells was investigated. ECV304 endothelial cells were used as a healthy cell line for the understanding of its selective cytotoxicity. To determine the effects of Isochrysis galbana extract, an MTT cytotoxicity assay was performed.Results: According to the results of the experiments, the highest cytotoxic effect of Isochrysis galbana microalgae extract was shown at about 24.07±6.48% cytotoxicity against Raji cells. There were a large number of bioactive molecules in the ex- tract, and these molecules showed a specific response to Raji cells when considering the synergistic and antagonistic effects of these molecules on each other.Conclusion: According to the results of GC-MS analysis of Isochrysis galbana microalgae extract, the most intense molecules in the content were Dodecanoic acid, 3-hydroxy- (CAS) Beta-Hydroxy Dodecanoic Acid, and Propanoic acid, 2-methyl-, 1-(1,1-dimethylethyl)-2-methyl-1,3-isonide. The investigation of the effect of these molecules specifically against Raji cells is important to determine the possible anti-leukemic molecules and their combinations that show cytotoxicity against this cell line.

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Bu Makaleye Atıf Yap

ARSLAN, B. A., YILANCIOĞLU, K., GÜLTEKİN, S. K., ALBAYRAK, İ. G. (2022). Chemical constituent of Isochrysis galbana microalgae extract and its cytotoxic activities on leukemic cell lines. İstanbul Journal of Pharmacy, Cilt: 52 - Sayı: 1, 64–68. https://ajindex.com/articles/676222

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Kaynakça (4)

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