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Dergiler / İstanbul Journal of Pharmacy / 2023 / Cilt: 53 Sayı: 2

Importance and review of drug metabolite synthesis

Zafer ŞAHİN
Pınar Sinem OMURTAG ÖZGEN
Sevim ROLLAS
Sayfa
251–269
Yayın Tarihi
2023-08-30
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Moreover, it showed that there was much more research available for Phase I than Phase II in the literature.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Phase I and Phase II metabolic reactions are involved in the pharmacokinetic properties of drugs after administration.
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Temel Bulgular & Veri:These reactions mainly aim to make drugs more polar and eliminate them safely.
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Sonuç & Katkı:Moreover, it showed that there was much more research available for Phase I than Phase II in the literature.
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Drug metabolite · metabolism · synthesis

Abstract

Phase I and Phase II metabolic reactions are involved in the pharmacokinetic properties of drugs after administration. These reactions mainly aim to make drugs more polar and eliminate them safely. However, some of these metabolites have the potential to exhibit a toxicological effect. Industry and/or academia have to consider these metabolites in terms of their pharmacodynamic and pharmacokinetic properties. These metabolites are not only residual intermediates from the synthetic process of the main drug but also unique structures produced by metabolic enzymes in the human organism. Thus, metabolite synthesis by synthetic or semi-synthetic methods is a key feature in the pharmaceutical industry. In this review, synthetic methods of the metabolites from all known metabolic pathways are reviewed from the literature. It was observed that both synthetic and semi-synthetic methods require more attention as they are as important and complex as drug synthesis. Moreover, it showed that there was much more research available for Phase I than Phase II in the literature.

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Bu Makaleye Atıf Yap

ŞAHİN, Z., ÖZGEN, P. S. O., ROLLAS, S. (2023). Importance and review of drug metabolite synthesis. İstanbul Journal of Pharmacy, Cilt: 53 Sayı: 2, 251–269. https://ajindex.com/articles/963650

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