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Dergiler / Turkish Journal of Chemistry / 2006 / Cilt: 30 - Sayı: 4

Short and effective synthesis of a thiophene analogue of $(pm)$-4-ipomeanol and its biological evaluation

Jürgen KRAUSS
Franz BRACHER
Doris UNTERREITMEIER
Sayfa
451–454
Yayın Tarihi
2022-11-05
DOI
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The resulting thiophene was tested in the MTT assay for its cytotoxic activity against HL 60 cells.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:The thiophene analogue of (±)-4-ipomeanol (1) was prepared in 2 steps starting from 3-iodothiophene and pent-4-yn-2-ol.
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Temel Bulgular & Veri:The key steps were a Sonogashira reaction, followed by HgO catalysed hydratisation of the triple bond.
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Sonuç & Katkı:The resulting thiophene was tested in the MTT assay for its cytotoxic activity against HL 60 cells.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Abstract

The thiophene analogue of (±)-4-ipomeanol (1) was prepared in 2 steps starting from 3-iodothiophene and pent-4-yn-2-ol. The key steps were a Sonogashira reaction, followed by HgO catalysed hydratisation of the triple bond. The resulting thiophene was tested in the MTT assay for its cytotoxic activity against HL 60 cells.

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Bu Makaleye Atıf Yap

KRAUSS, J., BRACHER, F., UNTERREITMEIER, D. (2022). Short and effective synthesis of a thiophene analogue of $(pm)$-4-ipomeanol and its biological evaluation. Turkish Journal of Chemistry, Cilt: 30 - Sayı: 4, 451–454. https://ajindex.com/articles/602206

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